scholarly journals Mental and Behavioural Disorders of Childhood and Adolescence: An Observational Study

2021 ◽  
pp. 189-194
Author(s):  
Shyamanta Das ◽  
Soumitra Ghosh ◽  
Dhrubajyoti Bhuyan ◽  
Hiranya Saikia ◽  
Hiranya Kumar Goswami ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Developmental Disorders ◽  
World Health ◽  
Childhood And Adolescence ◽  
Behavioural Disorders ◽  
Compulsive Disorder ◽  
Oppositional Defiant ◽  
Type 3 ◽  
Disorder Type

Background: There is overlap of symptoms in psychiatric disorders, especially in mental and behavioural disorders of childhood and adolescence. Half of all lifetime psychiatric disorders tend to arise by age 14 years and three fourths of them arise by age 24 years. Aim: To study the various types of mental and behavioural disorders of childhood and adolescence, and to find out comorbidities within and across the types. Methods: An observational cross-sectional study was carried out over a period of one year in the psychiatry department of a tertiary care general hospital. The psychiatric diagnoses according to the World Health Organization’s (WHO) tenth revision of the International Statistical Classification of Health and Related Problems (ICD-10) were categorised into type 1 (depression, anxiety, obsessive-compulsive disorder, and somatoform disorder), type 2 (attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder), type 3 (mental retardation, developmental disorders of speech and language, and scholastic skills, and pervasive developmental disorders). Descriptive statistics was used with frequency and percentage. Results: Total sample size was 137. Children and adolescents were almost equally distributed. Boys were more than girls. Type 3 disorders were maximum. Adolescents had mostly type 1 disorders. Children had mostly type 3 disorders. Girls had almost same number of type 1 and type 3 disorders. Boys had mostly type 3 disorders. Within group comorbidity was mostly with type 3 disorders. Across group comorbidity was highest in type2-type 3 disorders. Conclusion: Mental and behavioural disorders in childhood and adolescence do vary according to age and sex, and their recognition will help in the early diagnosis and proper management.

scholarly journals Circulation and Molecular Epidemiology of Enteroviruses in Paralyzed, Immunodeficient and Healthy Individuals in Tunisia, a Country with a Polio-Free Status for Decades

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 380
Author(s):  
Anissa Chouikha ◽  
Dorra Rezig ◽  
Nadia Driss ◽  
Ichrak Abdelkhalek ◽  
Ahlem Ben Yahia ◽  
...  
Keyword(s):  
Detection Rate ◽  
Warning System ◽  
World Health ◽  
Clinical Samples ◽  
Nucleotide Sequencing ◽  
Comprehensive Picture ◽  
Set Up ◽  
Health Organization ◽  
Type 3

This report is an overview of enterovirus (EV) detection in Tunisian polio-suspected paralytic cases (acute flaccid paralysis (AFP) cases), healthy contacts and patients with primary immunodeficiencies (PID) during an 11-year period. A total of 2735 clinical samples were analyzed for EV isolation and type identification, according to the recommended protocols of the World Health Organization. Three poliovirus (PV) serotypes and 28 different nonpolio enteroviruses (NPEVs) were detected. The NPEV detection rate was 4.3%, 2.8% and 12.4% in AFP cases, healthy contacts and PID patients, respectively. The predominant species was EV-B, and the circulation of viruses from species EV-A was noted since 2011. All PVs detected were of Sabin origin. The PV detection rate was higher in PID patients compared to AFP cases and contacts (6.8%, 1.5% and 1.3% respectively). PV2 was not detected since 2015. Using nucleotide sequencing of the entire VP1 region, 61 strains were characterized as Sabin-like. Among them, six strains of types 1 and 3 PV were identified as pre-vaccine-derived polioviruses (VDPVs). Five type 2 PV, four strains belonging to type 1 PV and two strains belonging to type 3 PV, were classified as iVDPVs. The data presented provide a comprehensive picture of EVs circulating in Tunisia over an 11-year period, reveal changes in their epidemiology as compared to previous studies and highlight the need to set up a warning system to avoid unnoticed PVs.

The role of brain-derived neurotrophic factor in the pathophysiology of adolescent suicidal behavior

2011 ◽  
Vol 23 (3) ◽  
Author(s):  
Leo Sher
Keyword(s):  
At Risk ◽  
Psychiatric Disorders ◽  
Suicidal Behavior ◽  
Neurotrophic Factor ◽  
Adolescent Suicide ◽  
Developmental Change ◽  
Brain Derived Neurotrophic Factor ◽  
Childhood And Adolescence ◽  
Compulsive Disorder

Abstract Adolescent suicide research has mostly focused on demographic risk factors. Such studies focus on who is at risk, but do not explain why certain adolescents are at risk for suicide. Studies of the neurobiology of adolescent suicide could clarify why some youths are more suicidal than others and help to find biological markers of suicidal behavior in teenagers. Over the past decade the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of suicidal behavior has attracted significant attention of scientists. BDNF is involved in the pathophysiology of many psychiatric disorders associated with suicidal behavior including depression, post-traumatic stress disorder, schizophrenia, and obsessive-compulsive disorder. BDNF dysregulation could be associated with increased suicidality independently of psychiatric diagnoses. BDNF plays an important role in the regulation and growth of neurons during childhood and adolescence. Prominent among the brain regions undergoing developmental change during adolescence are stressor-sensitive areas. The serotonin dysfunction found in adolescent and adult suicidal behavior could be related to the low level of BDNF, which impedes the normal development of serotonin neurons during brain development. BDNF dysfunction could play a more significant role in the pathophysiology of psychiatric disorders and suicidal behavior in adolescents than in adults. Treatment-induced enhancement in the BDNF function could reduce suicidal behavior secondary to the improvement in psychiatric pathology or independently of improvement in psychiatric disorders. It is interesting to hypothesize that BDNF could be a biological marker of suicidal behavior in adolescents or in certain adolescent populations.

The Impact of Recent Undesirable Life Events on Psychiatric Disorders in Childhood and Adolescence

1987 ◽  
Vol 151 (2) ◽  
pp. 179-184 ◽  
Author(s):  
I. M. Goodyer ◽  
I. Kolvin ◽  
Sonia Gatzanis
Keyword(s):  
Relative Risk ◽  
Psychiatric Disorder ◽  
Psychiatric Disorders ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Events ◽  
Childhood And Adolescence ◽  
Behavioural Disorders ◽  
Multiple Events ◽  
The Impact

The timing and number of recent stressful life events occurring in the year before onset of emotional or behavioural disorder was examined in a consecutive sample of children. Overall, events increase the relative risk of psychiatric disorder by 3–6 times. Events occur throughout the 12 months, but tend to cluster in the 16 weeks nearest onset of symptoms. The number of events influences the onset of disorder: cases with multiple events are more likely to have an event within 16 weeks of onset; cases with single events are more likely to have the event 36–52 weeks before onset. Cases whose onset occurs within 4 weeks of an event may have experienced single or multiple events. The results support the concept of additivity of recent stressful events in some cases of emotional and behavioural disorders in childhood.

scholarly journals Prenatal maternal infections and psychopathology in childhood and adolescence: Findings from the ALSPAC birth cohort

2020 ◽  
Author(s):  
Hildigunnur Anna Hall ◽  
Lydia Gabriela Speyer ◽  
MIchael Lombardo ◽  
Aja Louise Murray ◽  
Bonnie Auyeung
Keyword(s):  
Psychiatric Disorders ◽  
Emotional Disorders ◽  
Pervasive Developmental Disorders ◽  
Developmental Disorders ◽  
Child Outcomes ◽  
Well Being ◽  
Childhood And Adolescence ◽  
Parents And Children ◽  
Prenatal Infections ◽  
The Uk

Aims: Studies have suggested that exposure to prenatal infections may be a risk factor in the aetiology of neurodevelopmental disorders such as schizophrenia and autism, but that its effects may differ by timing of exposure. Evidence on other psychiatric outcomes, however, is scarce and mixed. The aims of this study were to examine whether exposure to infections, at any point in gestation and during each trimester, is associated with increased odds of psychiatric disorders (pervasive developmental disorders, attention-deficit hyperactivity disorder, behavioural disorders and emotional disorders) at ages 7 and 14. Methods: Participants were n = 8859 mother and child pairs from the UK Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Exposure to prenatal infections was assessed for each trimester using maternal self-reports. Children’s psychiatric status was assessed using the parent-reported Development and Well-being Assessment (DAWBA). Logistic regressions were used to examine links between prenatal infections and child outcomes. Results: Half of the mothers reported an infection at some point during pregnancy and 7% of children were reported to have a psychiatric condition. Increased odds of children having any psychiatric disorder at age 14 were found in association with infections at any point during pregnancy, OR = 1.27 (95% CI 1.04, 1.55) and in the third trimester specifically, OR = 1.28 (95% CI 1.02, 1.61), after adjusting for the effects of potential confounds and other covariates. No other links were found in adjusted models. Conclusions: Findings suggest that associations between prenatal infections and children’s psychiatric disorders are weak to non-existent, after adjusting for the effects of other factors.

scholarly journals Genetic overlap between schizophrenia and developmental psychopathology: a longitudinal approach applied to common childhood disorders between age 7 and 15 years

2016 ◽  
Author(s):  
Michel G. Nivard ◽  
Suzanne H. Gage ◽  
Jouke J. Hottenga ◽  
Catherina E.M. van Beijsterveldt ◽  
Abdel Abdellaoui ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Genetic Risk ◽  
Developmental Psychopathology ◽  
Adolescent Psychopathology ◽  
Risk Scores ◽  
Childhood And Adolescence ◽  
Genetic Etiology ◽  
Childhood Disorders ◽  
Oppositional Defiant ◽  
Shared Genetic

AbstractVarious non-psychotic psychiatric disorders in childhood and adolescence can precede the onset of schizophrenia, but the nature of this relationship remains unclear. We investigated to what extent the association between schizophrenia and psychiatric disorders in childhood is explained by shared genetic risk factors.Polygenic risk scores (PRS), reflecting an individual’s genetic risk for schizophrenia, were constructed for participants in two birth cohorts (2,588 children from the Netherlands Twin Register (NTR) and 6,127 from the Avon Longitudinal Study of Parents And Children (ALSPAC)). The associations between schizophrenia PRS and measures of anxiety, depression, attention deficit hyperactivity disorder (ADHD), and oppositional defiant disorder/conduct disorder (ODD/CD) were estimated at age 7, 10, 12/13 and 15 years in the two cohorts. Results were then meta-analyzed, and age-effects and differences in the associations between disorders and PRS were formally tested in a meta-regression.The schizophrenia PRS was associated with childhood and adolescent psychopathology Where the association was weaker for ODD/CD at age 7. The associations increased with age this increase was steepest for ADHD and ODD/CD. The results are consistent with a common genetic etiology of schizophrenia and developmental psychopathology as well as with a stronger shared genetic etiology between schizophrenia and adolescent onset psychopathology.A multivariate meta-analysis of multiple and repeated observations enabled to optimally use the longitudinal data across diagnoses in order to provide knowledge on how childhood disorders develop into severe adult psychiatric disorders.

scholarly journals Experimental huts trial of the efficacy of pyrethroids/piperonyl butoxide (PBO) net treatments for controlling multi-resistant populations of Anopheles funestus s.s. in Kpomè, Southern Benin

2018 ◽  
Vol 3 ◽  
pp. 71 ◽  
Author(s):  
Romaric Akoton ◽  
Genevieve M. Tchigossou ◽  
Innocent Djègbè ◽  
Akadiri Yessoufou ◽  
Michael Seun Atoyebi ◽  
...  
Keyword(s):  
High Performance ◽  
Anopheles Funestus ◽  
Piperonyl Butoxide ◽  
World Health ◽  
Experimental Huts ◽  
New Generation ◽  
Type 3 ◽  
Southern Benin

Background: Insecticides resistance in Anopheles mosquitoes limits Long-Lasting Insecticidal Nets (LLIN) used for malaria control in Africa, especially Benin. This study aimed to evaluate the bio-efficacy of current LLINs in an area where An. funestus s.l. and An. gambiae have developed multi-resistance to insecticides, and to assess in experimental huts the performance of a mixed combination of pyrethroids and piperonyl butoxide (PBO) treated nets on these resistant mosquitoes. Methods: The study was conducted at Kpomè, Southern Benin. The bio-efficacy of LLINs against An. funestus and An. gambiae was assessed using the World Health Organization (WHO) cone and tunnel tests. A released/recapture experiment following WHO procedures was conducted to compare the efficacy of conventional LLINs treated with pyrethroids only and LLINs with combinations of pyrethroids and PBO. Prior to huts trials, we confirmed the level of insecticide and PBO residues in tested nets using high performance liquid chromatography (HPLC). Results: Conventional LLINs (Type 2 and Type 4) have the lowest effect against local multi-resistant An. funestus s.s. and An. coluzzii populations from Kpomè. Conversely, when LLINs containing mixtures of pyrethroids and PBO (Type 1 and Type 3) were introduced in trial huts, we recorded a greater effect against the two mosquito populations (P < 0.0001). Tunnel test with An. funestus s.s. revealed mortalities of over 80% with this new generation of LLINs (Type 1 and Type 3),while conventional LLINs produced 65.53 ± 8.33% mortalities for Type 2 and 71.25 ±7.92% mortalities for Type 4. Similarly, mortalities ranging from 77 to 87% were recorded with the local populations of An. coluzzii. Conclusion: This study suggests the reduced efficacy of conventional LLINs (Pyrethroids alone) currently distributed in Benin communities where Anopheles populations have developed multi-insecticide resistance. The new generation nets (pyrethroids+PBO) proved to be more effective on multi-resistant populations of mosquitoes.

scholarly journals Pattern of psychiatric morbidity in pediatric outpatient department

2020 ◽  
Vol 31 (1) ◽  
pp. 1-6
Author(s):  
Jesmin Akhter ◽  
Md Azizul Islam ◽  
Mohammad Muntasir Maruf ◽  
Tania Binte Gofur
Keyword(s):  
Psychiatric Disorders ◽  
Psychiatric Morbidity ◽  
Sampling Technique ◽  
Well Being ◽  
Outpatient Department ◽  
Behavioral Disorder ◽  
Tertiary Level ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Oppositional Defiant

Mental health in child and adolescents is an essential component of overall health. Disturbed children are more likely to be disturbed adults. Therefore, early detection and treatment is important to decrease the long term disability. The objective of the study was to determine the morbidity pattern of psychiatric disorders among patients of pediatric outpatient department of tertiary level hospitals. This cross-sectional study was conducted from July 2012 to February 2013 in pediatric outpatient department of three prime tertiary level hospitals of Dhaka, Bangladesh. Purposive sampling technique was used and sample size was 240. A Semi- structured questionnaire containing socio-demographic and other relevant clinical information and the parent version of Development and Well Being Assessment (DAWBA) were applied. The results showed that most (70.8%) of the respondents were of 5 to 10 years’ age group with a male preponderance (54.2%). Out of 240 respondents, 44 (18.3%) were found with psychiatric morbidity. Categorically emotional disorder was 14.6%, behavioral disorder was 9.2% and developmental disorder was 0.4%. Hyperkinetic disorder (5.4%) and Oppositional defiant disorder (2.9%) were the most frequent diagnoses, followed by Obsessive compulsive disorder (2.5%). 29.5% of psychiatric cases were associated with other comorbid psychiatric diagnoses. Respondents with minor physical illness were mostly found with psychiatric morbidity (43.2%). Multiple patterns of psychiatric disorders were identified among the respondents. Therefore, the need to step up to the clinical and referral approaches is imperative to this special segment of children of our society. Bang J Psychiatry June 2017; 31(1): 1-6

Special Populations

CNS Spectrums ◽  
2007 ◽  
Vol 12 (S3) ◽  
pp. 36-42 ◽  
Author(s):  
Joseph Zohar ◽  
Leah Fostick ◽  
Donald W. Black ◽  
Juan J. Lopez-Ibor
Keyword(s):  
Psychiatric Disorders ◽  
Treatment Response ◽  
Primary Care Physicians ◽  
Clinical Symptoms ◽  
Public Health Problem ◽  
World Health ◽  
Elderly Persons ◽  
Late Adolescent ◽  
Compulsive Disorder ◽  
Comorbid Psychiatric Disorders

AbstractObsessive-compulsive disorder (OCD) is a formidable public health problem, rated by the World Health Organization as one of the top 20 most disabling diseases.The shame and secrecy associated with OCD, as well as the lack of recognition of its characteristic symptoms, particularly by primary care physicians, hinders appropriate diagnosis and treatment. Most adults with OCD report a late adolescent or early adulthood onset, yet OCD can occur throughout the life span. Pre-school children have been known to develop the disorder, as have elderly persons. OCD can cause considerable distress and disability; for example, children may fall behind in their education, and adults can become housebound. Comorbid psychiatric disorders have become an area of intense interest. Comorbid depression for example, is frequently the symptom that leads the individual to seek treatment. Patients with schizophrenia frequently develop obsessions and compulsions, and these symptoms are associated with a poorer outcome. The role of second-generation antipsychotics merits further study in the treatment of this subset of patients. An important step toward delineating specific subgroups within the OCD-schizophrenia axis may be the use of endophenotypic markers. Unfortunately, many patients with OCD will have a less than optimal treatment response. Poor treatment response is associated with serious social disability, but there are few clues to guide clinicians in predicting treatment response in patients with OCD, in terms of specific demographic variables, clinical symptoms, or the presence of comorbid psychiatric disorders.

FUNCTIONAL STATUS AND ADAPTIVE POTENTIAL IN FOREIGN STUDENTS WITH DIFFERENT TYPES OF VEGETATIVE REGULATION DURING TUITION

2020 ◽  
pp. 118-126
Author(s):  
A.M. Satarkulova
Keyword(s):  
Heart Rate ◽  
Foreign Students ◽  
Autonomic Regulation ◽  
The Body ◽  
Functional Changes ◽  
Different Types ◽  
Type 3 ◽  
Adaptive Abilities

The assessment and dynamic control over students’ status is a very important task. It allows timely detection of prenosological status prior to pathology and health maintenance in students. The objective of the paper is to assess the adaptive abilities of the body, to analyze changes in heart rate variability indicators in students with various types of autonomic regulation, to identify prenosological status and precursory pathological symptoms. Materials and Methods. The study enrolled 302 students from India, aged 21.54±1.43. Programming complex «Psychophysiologist» was used to register the main HRV parameters within 5 minutes. Health status was evaluated according to the index of functional changes and the scale of functional states. Results. N.I. Shlyk (2009) distinguished two groups of students with different types of autonomic regulation: type 1 (53 %) with moderate and type 2 (5 %) with marked characteristics of central regulation profile, type 3 (35 %) with moderate and type 4 (7 %) with marked characteristics of autonomous regulation profile. Main parameters of HRV and adaptation potential were defined for each student.All the parameters characterized functional and health status. Conclusions. It was shown that 82 % of trial subjects (type 1), 53 % (type 2), 94 % (type 3) and 95 % (type 4) demonstrated satisfactory adaptation and their physiological processes were at an optimal level. 18 % of students (type 1) demonstrated reduced adaptive abilities of the body. Moreover, they were under moderate stress. 47 % of subjects (type 2) were also under a significant stress, which was proven by excessively high SI, low SDNN and TP, and an increased index of functional changes. 5 % of students (type 4) revealed dysfunctional characteristics in the heart rhythm, peculiar to pathology. Keywords: foreign students, heart rate variability, types of autonomic regulation, adaptation potential, functional status. Оценка состояния студентов и динамический контроль за ним является важной задачей, поскольку позволяет своевременно выявлять у студентов донозологические состояния, предшествующие патологии, и способствовать сохранению здоровья. Цель. Оценка адаптивных возможностей организма, анализ изменений показателей вариабельности сердечного ритма у студентов с различными типами вегетативной регуляции, выявление донозологических состояний и ранних признаков патологии. Материалы и методы. В исследовании участвовало 302 студента в возрасте 21,54+1,43 года из Индии. Регистрировались основные параметры ВСР в течение 5 мин с использованием программно-аппаратного комплекса «Психофизиолог». Состояние и уровень здоровья оценивались по индексу функциональных изменений и шкале функциональных состояний. Результаты. По способу, предложенному Н.И. Шлык, выделены группы студентов с различными типами вегетативной регуляции: I (53 %) и II типы (5 %) – с умеренным и выраженным преобладанием центрального контура регуляции соответственно, III (35 %) и IV типы (7 %) – с умеренным и выраженным преобладанием автономного контура регуляции соответственно. У каждого из студентов определены основные параметры ВСР и адаптационного потенциала, характеризующие функциональное состояние и уровень здоровья. Выводы. Показано, что для 82 % обследуемых с I типом, 53 % со II типом, 94 % c III типом и 95 % с IV типом регуляции характерно состояние удовлетворительной адаптации, физиологические процессы сохраняются на оптимальном уровне. В группе студентов I типа у 18 % студентов адаптивные возможности организма снижены, выявлено состояние умеренного напряжения. У 47 % обследуемых II типа также зафиксировано состояние резко выраженного напряжения, индикатором которого является чрезмерно высокое значение SI, низкие величины SDNN и ТP, повышенное значение индекса функциональных изменений. В группе студентов с IV типом у 5 % учащихсяв регуляции ритма сердца выявлены дисфункциональные признаки, характерные для патологии. Ключевые слова: иностранные студенты, вариабельность сердечного ритма, типы вегетативной регуляции, адаптационный потенциал, функциональное состояние.

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