scholarly journals Effect of Moderate Intensity Exercise on Lungs Functions (IRV & ERV) in Young Athletes

2021 ◽  
pp. 67-74
Author(s):  
Noor Muhammad ◽  
Alamgir Khan ◽  
Muhammad Zafar Iqbal Butt ◽  
Shahzaman Khan ◽  
Sobia Nazir ◽  
...  
Keyword(s):  
Data Analysis ◽  
Informed Consent ◽  
Physical Education ◽  
Research Study ◽  
Moderate Intensity ◽  
Young Athletes ◽  
Moderate Intensity Exercise ◽  
Statistical Tools ◽  
Sports Sciences ◽  
Written Informed Consent

This research study was primarily conducted for the purpose to examine the effect of moderate intensity exercise on lungs functions (IRV & ERV) in young athletes. The participant of the study was randomly selected from the Department of Sports Sciences & Physical Education, Gomal University, KP Pakistan. A written informed consent was taken from all the subjects. A self-made, 08 weeks exercise protocols was applied on the selected subjects. Pretest and posttest data were collected by using spirometer and other helping devices. The collected data were tabulated and were analyzed by using various statistical tools. On the basis of data analysis and findings the researcher concluded there is significant effect of 08 weeks moderate intensity exercise on lungs functions (IRV & ERV).      

scholarly journals INFORMED CONSENT DOKTER DAN PASIEN BERDASARKAN ASAS GOOD FAITH

2020 ◽  
Vol 3 (1) ◽  
pp. 124-144
Author(s):  
Yenni Safitri
Keyword(s):  
Data Analysis ◽  
Informed Consent ◽  
Research Method ◽  
Research Study ◽  
Civil Code ◽  
Good Faith ◽  
Legal Research ◽  
Sense Of Security ◽  
The Right ◽  
Legal Consequences

ABSTRAKPerjanjian informed consent harus dilaksanakan dengan asas itikad baik. Asas ini merupakan asas bahwa para pihak, yaitu pihak kreditur dan debitur harus melaksanakan substansi kontrak berdasarkan kepercayaan atau keyakinan yang teguh maupun kemauan baik dari para pihak. Tulisan ini membahas informed consent Dokter dan Pasien berdasarkan asas Good Faith dan akibat hukum tidak dilaksanakannya informed consent Dokter dan Pasien berdasarkan asas Good Faith. Metode penelitian adalah penelitian hukum normative kajian tentang asas hukum, peneliti mengumpulkan data yang terdiri dari data primer, sekunder dan tertier. Teknik pengumpulan data yaitu wawancara dan kajian kepustakaan. Analisis data dilakukan secara kualitatif serta menarik kesimpulan penulis menggunakan metode berfikir deduktif.Kesimpulan dari penelitian ini adalah Informed consent antara dokter dan pasien harus berdasarkan asas good faith, bagi dokter informed consent memberikan rasa aman dalam menjalankan tindakan medis terhadap pasien. Bagi pasien, informed consent merupakan merupakan perwujudan dari hak pasien dimana pasien berhak mendapatkan informasi tentang penyakit yang dideritanya, tindakan medis apa yang hendak dilakukan, kemungkinan yang akan terjadi atas pengambilan keputusan tindakan medis. Apabila tidak ada informed consent berakibat tidak terpenuhinya salah satu syarat perjanjian menurut Pasal 1320 KUH Perdata, digolongkan sebagai wanprestasi dan digolongkan sebagai perbuatan melawan hukum berdasarkan Pasal 1365 KUHPerdata.Kata kunci: informed consent; good faith; dokter dan pasienABSTRACTAn informed consent agreement must be carried out in good faith. This principle is the principle that the parties, namely the creditors and debtors must carry out the substance of the contract based on the trust or firm belief or goodwill of the parties. This paper discusses the informed consent of Doctors and Patients based on the Good Faith principle and the legal consequences of not implementing the informed consent of Doctors and Patients based on the Good Faith principle. The research method is a normative legal research study of the principle of law, researchers collect data consisting of primary, secondary and tertiary data. Data collection techniques, namely interviews and literature review. Data analysis was carried out qualitatively and drawing conclusions from the author using deductive thinking methods. The conclusion of this study is that informed consent between doctors and patients must be based on the principle of good faith, for physicians informed consent to provide a sense of security in carrying out medical actions against patients. For patients, informed consent is an embodiment of the patient's right where the patient has the right to get information about the disease he is suffering from, what medical action he wants to take, the likelihood that will occur in making a decision on medical action. If no informed consent results in failure to fulfill one of the terms of the agreement under Article 1320 of the Civil Code, it is classified as a default and is classified as unlawful pursuant to Article 1365 of the Civil Code. Keywords: informed consent; good faith; doctors and patients

Variability in Institutional Board Review for a Multisite Assessment of Resident Professionalism

2019 ◽  
Vol 14 (2) ◽  
pp. 117-125 ◽  
Author(s):  
Judith A. Linden ◽  
Jeffrey I. Schneider ◽  
Andrea Cotter ◽  
Sabrina Drexel ◽  
Emily Frosch ◽  
...  
Keyword(s):  
Informed Consent ◽  
Educational Research ◽  
Research Study ◽  
Institutional Review Board ◽  
Professional Behaviors ◽  
National Board ◽  
Institutional Review ◽  
Board Review ◽  
Medical Examiners ◽  
Written Informed Consent

Residents serve as both trainees and employees and can be considered potentially vulnerable research participants. This can lead to variation in the institutional review board (IRB) review. We studied sites participating in the Assessment of Professional Behaviors Study sponsored by the National Board of Medical Examiners (2009-2011). Of the 19 sites, all but one were university affiliated. IRB review varied; 2/19 did not submit to a local IRB, 4/17 (23%) were exempt, 11/17 (65%) were expedited, and 2/17 (12%) required full Board review; 12/17 (71%) required written informed consent. The interval from submission to approval was 1 to 2 months (8/17); the range was 1 to 7 months. Although most stated there were no major barriers to approval, the most common concern was resident coercion and loss of confidentiality. Local IRB review of this educational research study varied.

scholarly journals Exercise as an Emerging Factor Effecting Cardiovascular Health (An Experimental Approach)

2021 ◽  
pp. 193-205
Author(s):  
Alamgir Khan ◽  
Muhammad Zafar Iqbal Butt ◽  
Shahzaman Khan ◽  
Abdul Jabbar Tanweer ◽  
Abdul Manan Tanweer ◽  
...  
Keyword(s):  
Test Data ◽  
Cardiovascular Health ◽  
Step Test ◽  
Moderate Intensity ◽  
Control Group ◽  
Exercise Protocol ◽  
Moderate Intensity Exercise ◽  
Post Test ◽  
Experimental Group ◽  
Written Informed Consent

This resaerch study was basically carried out for the purpose to assess the effect of moderate intensity exercise on cardiovascular health. Ten (10) participants were voluntarily selected and thus they were randomly divided into two (02) groups i.e. (Experimental Group (EG)=05+ Control Group (CG)=05.A self-made eight weeks’ self-made moderate intensity exercise protocol was applied on all the subjects. Pre and post test data were collected through Harvard Step Test. A written informed consent was taken from each subject before participation in the study. All participants were informed about the benefits and risk factors of the study. After fulfilling all the ethical protocols, eight weeks self-made moderate intensity exercise protocol was applied on all the subjects. Pre and post test data were collected through Harvard Step Test. The collected data were tabulated and analyzed by using various statistical tools. On the basis of analysis the researcher arrived at conclusion that exercise has a significant effect on cardiovascular health.

Risk Minimization Measures in Off-Label Drug Use: A Survey of Community Pharmacists in Malaysia

2020 ◽  
Vol 15 (3) ◽  
pp. 181-189
Author(s):  
Omotayo Fatokun
Keyword(s):  
Informed Consent ◽  
Drug Use ◽  
Perceived Risk ◽  
Adverse Drug Events ◽  
Community Pharmacists ◽  
Risk Minimization ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Off Label ◽  
Written Informed Consent

Background: While off-label drug use is common and sometimes necessary, it also presents considerable risks. Therefore, measures intended to prevent or reduce the potential exposure to off-label risks have been recommended. However, little is known about community pharmacists’ beliefs regarding these measures in Malaysia. Objectives: This study examined community pharmacists’ beliefs towards risk minimization measures in off-label drug use in Malaysia and assessed the relationship between perceived risk of off-label drug use and beliefs towards risk minimization measures. Methods: A cross-sectional survey was conducted among 154 pharmacists practicing in randomly selected community pharmacies in Kuala Lumpur and the State of Selangor, Malaysia. Results: The majority agreed or strongly agreed that adverse drug events from the off-label drug should be reported to the regulatory authority (90.9%) and the off-label drug should only be used when the benefit outweighs potential risks (88.3%). Less than half (48.1%) agreed or strongly agreed that written informed consent should be obtained before dispensing off-label drugs and a majority (63.7%) agreed or strongly agreed that the informed consent process will be burdensome to healthcare professionals. Beliefs towards risk minimization measures were significantly associated with perceived risk of off-label drug use regarding efficacy (p = 0. 033), safety (p = 0.001), adverse drug rection (p = 0.001) and medication errors (p = 0.002). Conclusion: The community pharmacists have positive beliefs towards most of the risk minimization measures. However, beliefs towards written informed consent requirements are not encouraging. Enhancing risk perception may help influence positive beliefs towards risk minimization measures.

scholarly journals Hypertrophic Cardiomyopathy: Updates Through the Lens of Sports Cardiology

2021 ◽  
Vol 23 (8) ◽  
Author(s):  
Bradley S. Lander ◽  
Dermot M. Phelan ◽  
Matthew W. Martinez ◽  
Elizabeth H. Dineen
Keyword(s):  
Decision Making ◽  
Hypertrophic Cardiomyopathy ◽  
Shared Decision Making ◽  
Sport Participation ◽  
Heart Association ◽  
Moderate Intensity ◽  
Implantable Cardioverter Defibrillators ◽  
Shared Decision ◽  
Moderate Intensity Exercise ◽  
Sports Cardiology

Abstract Purpose of review This review will summarize the distinction between hypertrophic cardiomyopathy (HCM) and exercise-induced cardiac remodeling (EICR), describe treatments of particular relevance to athletes with HCM, and highlight the evolution of recommendations for exercise and competitive sport participation relevant to individuals with HCM. Recent findings Whereas prior guidelines have excluded individuals with HCM from more than mild-intensity exercise, recent data show that moderate-intensity exercise improves functional capacity and indices of cardiac function and continuation of competitive sports may not be associated with worse outcomes. Moreover, recent studies of athletes with implantable cardioverter defibrillators (ICDs) demonstrated a safer profile than previously understood. In this context, the updated American Heart Association/American College of Cardiology (AHA/ACC) and European Society of Cardiology (ESC) HCM guidelines have increased focus on shared decision-making and liberalized restrictions on exercise and sport participation among individuals with HCM. Summary New data demonstrating the safety of exercise in individuals with HCM and in athletes with ICDs, in addition to a focus on shared decision-making, have led to the most updated guidelines easing restrictions on exercise and competitive athletics in this population. Further athlete-specific studies of HCM, especially in the context of emerging therapies such as mavacamten, are important to inform accurate risk stratification and eligibility recommendations.

274 Tumoral and peripheral immunophenotype of refractory vs relapse to PD-(L)1 blockade in patients with advanced non-small cell lung cancer

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A299-A299
Author(s):  
Maria Ascierto ◽  
Matthew Hellmann ◽  
Nathan Standifer ◽  
Song Wu ◽  
Han Si ◽  
...  
Keyword(s):  
Gene Expression ◽  
Informed Consent ◽  
Checkpoint Inhibitors ◽  
Patient Response ◽  
Calcium Dependent ◽  
Immune Exhaustion ◽  
Previously Treated ◽  
Expression Pathways ◽  
Relapsed Disease ◽  
Written Informed Consent

BackgroundDespite the encouraging successes of immune checkpoint inhibitors, many patients do not benefit and are either refractory or relapse. The mechanisms of refractory or relapsed disease following PD-(L)1 blockade are largely unknown. To identify characteristics associated with refractory or relapsed disease we explored the immune and genomic landscape of samples derived from NSCLC patients who previously received PD-(L)1 blockade and had blood and fresh tumor biopsies collected at the time of progression.MethodsPatient response categories were defined prospectively; ‘refractory’ defined as progression within 16 weeks of initiating PD-(L)1 and ‘relapse’ defined as initial clinical benefit (CR, PR, SD) followed by progression. RNAseq (n=52) and PD-L1 IHC (n=22) were performed on tumor tissue. Immune profiling of whole blood was assessed using flow cytometry or Biomark HD (Fluidigm) gene expression panel (n=54 and n=62, respectively). Differential gene expression was defined as unadjusted p<0.05 and fold-difference >1.5. Pathways analysis was conducted by David tool. Patient samples were collected during screening for clinical trial of second line immunotherapy. Written informed consent was obtained from the patients for publication of this abstract.ResultsIn patients with NSCLC previously treated with PD-(L)1 blockade, tumors of relapsed patients were characterized by increased expression of genes associated with interferon signaling (e.g. CXCL9, SPIC, IFNg), immune suppression (e.g. ARG1, TGFB), immune exhaustion (e.g. ADORA2A), and increased PD-L1 expression (by gene expression and IHC). Refractory disease was associated with increased cadherin signaling and calcium-dependent-cell-adhesion gene expression pathways. In the periphery, reduced quantities of B cells and activated (HLA-DR+ or CD38+) or proliferating (Ki67+) CD8+ T cells were observed in refractory patients.ConclusionsThe tumor and peripheral compartments of patients with NSCLC previously treated with PD-(L)1 blockade differ based on prior response. Relapsed patients tend to have signals of sturdy immune activation and chronic inflammation thus ultimately leading to immune exhaustion. These results may help inform rational therapeutic strategies to overcome resistance to PD-(L)1 blockade in NSCLC.Trial RegistrationNCT02000947Ethics ApprovalResearch on human samples here analyzed have been performed in accordance with the Declaration of Helsinki.ConsentWritten informed consent was obtained from the patient for publication of this abstract.

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