Formulation and Evaluation of Orodispersible Tablet for Anti-Asthamatic Drug

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i51a33484 ◽

2021 ◽

pp. 187-199

Author(s):

Amitkumar M. Lokade ◽

Priya G. Shete ◽

Neha G. Shete ◽

Deepak S. Khobragade ◽

Awdhut D. Pimpale ◽

...

Keyword(s):

Orodispersible Tablet

Objective iof ithe ipresent iwork iis ito idevelop iorodispersible itablets iof iSalbutamol i ito iimprove ibioavailability, idisintegration itime, idissolution iefficacy iand ipatient icompliance. iOrodispersible itablets iare ithe ifast igrowing iand ihighly iaccepted idrug idelivery isystem iin inow idays imainly ito iimprove ipatient icompliance. iOrodispersible itablets ihave inumber iof iadvantages iover iconventional idosage iforms, ibecause iof ithat iOrodispersible itablets ihave iemerged ias ian ialternative ito iconventional idosage iforms. Orodispersible itablets idissolve ior idisintegrates iinstantly ion ithe ipatient itongue ior ibuccal imucosa. iOrodispersible itablets iof isolbutamol i iwere iprepared iusing isuperdisintegrants, iCrospovidone,Mannitol (Pearlitol iSD-200), ias idiluents iby idirect icompression imethod. iNine iformulations iwere iprepared iusing ithe isuperdisintegrants iat ilower, iintermediate i& ihigher iconcentration. iMannitol iis iused ito ienhance ithe iorganoleptic iproperties iof itablets. iTablets iwere ievaluated ifor iuniformity iof iweight, ihardness, ifriability, iwater iabsorption iratio, idispersion itime, idisintegration itime iand iin ivitro idrug irelease. iAll ithe iformulations ishowed idisintegration itime iless ithan i33 mins iand idrug irelease iby idissolution i(100% iat ithe iend iof i10 imins).

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EVALUATION OF MUSA ACUMINATA FRUIT AS A NATURAL SUPERDISINTEGRANT FOR TABLET FORMULATION

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i10.26958 ◽

2018 ◽

Vol 11 (10) ◽

pp. 167

Author(s):

Gopinath E

Keyword(s):

Nutritive Value ◽

Low Cost ◽

Cost Effective ◽

Musa Acuminata ◽

Tablet Formulation ◽

Angle Of Repose ◽

Average Weight ◽

Disintegration Time ◽

Solubility Study ◽

Orodispersible Tablet

Objective: The objective of the present work was to develop and evaluate a new, low-cost effective superdisintegrant from Musa acuminata fruit for tablet formulation.Methods: The study involved collection of M. acuminata fruit powdered and evaluated for physicochemical properties. Propranolol Hcl was used as a model drug for tablet formulation. Different concentrations of M. acuminatea powder were used as superdisintegrant, and orodispersible tablet is prepared and evaluated. In the present study, sodium starch glycolate was used as synthetic superdisintegrant for comparative study.Result: The powder was dark brownish and did not change throughout the study. The percentage porosity of powder was found to be 42.88% and angle of repose of was found to be 33.69°. The solubility study shows that the powders are sparingly soluble in water and disperse into individual particles. Total ash and acid insoluble ash values of powder were found to be 2.61 and 2.11% w/w, respectively. The average weight of tablets was ranged from 101.42 to 103.52 mg and averaged hardness was found to be 3.4 kg/cm2. Moreover, the tablets exhibited acceptable friability. Disintegration time of all formulations was found to be in the range of 22–80 s and wetting time was found to be 07–18 s.Conclusion: From the study, it was concluded that M. acuminatea powder in the range of 2–12% can be used as superdisintegrant in orodispersible tablet formulation and shall be preferred as having nutritive value as well as cost profit in the development of orodispersible tablet than synthetic polymer.

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Formulation and Evaluation of Orodispersble Tablet

Asian Journal of Research in Pharmaceutical Science ◽

10.52711/2231-5659.2021.00042 ◽

2021 ◽

pp. 267-272

Author(s):

Pratiksha S. Deore ◽

Yashpal M. More ◽

Avish D. Maru

Keyword(s):

Rapid Onset ◽

Nausea And Vomiting ◽

Direct Compression ◽

Compression Method ◽

Onset Of Action ◽

Orodispersible Tablet ◽

Croscarmellose Sodium

The aim of present work is to formulate and develop tablets of promethazine HCL.by using various superdisintegrating agent by direct compression method. The main objective of the study is to increase rapid onset of action of promethazine HCL in the treatment of nausea and vomiting. The orodispersible tablet of promethazine hcl is were prepared by direct compression method. Using different concentration of Crospovidone, croscarmellose sodium Mannitol, lactose, maltose, mg. stearate. The tablet was evaluated by various parameters and result are found to be satisfactory.

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Development of Tropisetron Hydrochloride Orodispersible Tablet using Natural Superdisintigrants

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i28a31523 ◽

2021 ◽

pp. 191-210

Author(s):

Rupalben K. Jani ◽

Gohil Krupa ◽

Aanal Gandhi ◽

Vijay Upadhye ◽

Roshani Pragnesh Amin

Keyword(s):

Drug Candidate ◽

Antiemetic Drug ◽

Onset Of Action ◽

Disintegration Time ◽

Cassia Tora ◽

Weight Variation ◽

Orodispersible Tablet ◽

Value Loss ◽

Time Required

The foremost objective of this research was to compare and evaluate natural super disintegrants with synthetic super disintegrants for the preparation of the orodispersible tablet. Tropisetron hydrochloride is widely used as an antiemetic drug, which is a potential drug candidate for developing an orodispersible tablet for quick onset of action. Various formulations were prepared using different concentrations (5%, 7.5%, and 10%) by direct compression method of natural super disintegrants (Banana power and Cassia tora powder) and synthetic super disintegrants (Croscarmellose sodium, Crospovidone, and Sodium starch glycolate). The compatibility studies between the drug and excipients were carried out using FTIR spectroscopy before tablet formulation. The pre-compression parameters were evaluated for additive properties. Standardization of banana powder was done by various parameters like extractive value, ash value, loss on drying, TLC identification test, etc. Post-compression parameters like hardness, weight variation, friability, thickness, the time required for disintegration, wetting time, the release of drug in-vitro, and in-vitro dispersion time of the tablets were evaluated. The disintegration time and in-vitro drug release of optimized formulation (F2) were found to be 4.66±1.15 secs and 99.25±0.15%. The optimized formulation (F2) was subjected to stability studies (40 C& 75 % RH) for one month. The results were shown that natural super disintegrants require less disintegration time as compared to synthetic super disintegrants. Hence present study reveals that the orodispersible tablets prepared using Banana powder and Cassia tora powder is super disintegrants that shown better appearance and rapid disintegration time.

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