scholarly journals Age-related Distribution of Mycoplasma pneumoniae in Respiratory Tract Infection in a Developing Country

Author(s):  
C. N. Adike ◽  
N. R. Agbakoba ◽  
I. B. Enweani ◽  
Emmanuel Ifeanyi Obeagu ◽  
Ifeoma Stella Ekelozie

Mycoplasma pneumoniae is an organism that belongs to the family mycoplasmataceae. Its role as a disease causing agent continues to draw interest especially with the advent of highly sensitive detection techniques. This bacterium poses a health problem to both animals and humans resulting in serious illnesses such as community-acquired pneumonia, lung damage and this work investigated the prevalence of M. pneumoniae as agent of respiratory tract infections using culture and molecular methods of identification, in patients attending Pulmonary Tuberculosis Clinic at Nnamdi Azikiwe Teaching, Hospital, Nnewi as well as detecting the most virulence gene of this organism. A total of 263 sputum samples were collected: 188 test subjects and 75 control subjects. These samples were examined bacteriologically using PPLO broth and agar, MacConkey, blood and chocolate agars. The overall prevalence rates of M. pneumoniae among the 263 subjects were 4.9% by culture. The prevalence rate of the organism was significantly higher among the test subjects 11(5.9%) by culture than the control subjects 2(2.7%) by culture. The colonization of the organism was significant among the age groups 31-40 years (P<0.05). The antibiotic sensitivity pattern of M. pneumoniae showed that the organism was susceptible to Lyntriaxone, Levofloxacin, Ciprofloxacin, Azithromycin and Doxycycline while it showed resistance to Septrin, Peflacine, Rifampicin, Erythromycin and Norbactin. M. pneumoniae is an additional bacterium that might contribute to respiratory tract infections and consequently to death when it disseminates to various organs of the body, hence their presence in the respiratory tract of children, adolescent and adults should not be treated with levity.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuyun Li ◽  
Dongming Wang ◽  
Lili Zhi ◽  
Yunmei Zhu ◽  
Lan Qiao ◽  
...  

AbstractTo describle how respiratory tract infections (RTIs) that occurred in children with allergic asthma (AA) on allergen immunotherapy (AIT) during an influenza season. Data including clinical symptoms and treatment history of children (those with AA on AIT and their siblings under 14 years old), who suffered from RTIs during an influenza season (Dec 1st, 2019–Dec 31st, 2019), were collected (by face to face interview and medical records) and analyzed. Children on AIT were divided into 2 groups: stage 1 (dose increasing stage) and stage 2 (dose maintenance stage). Their siblings were enrolled as control. During the study period, 49 children with AA on AIT (33 patients in stage 1 and 16 patients in stage 2) as well as 49 children without AA ( their siblings ) were included. There were no significant differences in occurrences of RTIs among the three groups (p > 0.05). Compared with children in the other two groups, patients with RTIs in stage 2 had less duration of coughing and needed less medicine. Children on AIT with maintenance doses had fewer symptoms and recovered quickly when they were attacked by RTIs, which suggested that AIT with dose maintenance may enhance disease resistance of the body.


2009 ◽  
Vol 53 (5) ◽  
pp. 2158-2159 ◽  
Author(s):  
Deli Xin ◽  
Zuhuang Mi ◽  
Xu Han ◽  
Ling Qin ◽  
Jing Li ◽  
...  

ABSTRACT Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.


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