b complex vitamins
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2021 ◽  
Vol 9 ◽  
Author(s):  
Naomi D'souza ◽  
Rishikesh V. Behere ◽  
Bindu Patni ◽  
Madhavi Deshpande ◽  
Dattatray Bhat ◽  
...  

Background: The first thousand days window does not include the pre-conceptional period. Maternal pre-conceptional health has a profound influence on early embryonic development (implantation, gastrulation, placentation etc). Nutrition provided by B-complex vitamins is important for fetal growth, especially neural development. We report effects of a maternal pre-conceptional vitamin B12 and multi micronutrient (MMN) supplementation on offspring neurodevelopmental performance.Methods: In the Pune Rural Intervention in Young Adolescents trial (PRIYA), adolescents (N = 557, 226 females) were provided with vitamin B12 (2 μg/day) with or without multiple micronutrients, or a placebo, from preconception until delivery. All groups received mandatory iron and folic acid. We used the Bayley's Scale of Infant Development (BSID-III) at 24–42 months of age to investigate effects on offspring neurodevelopment.Results: Participants had similar baseline B12 levels. The levels improved in the B12 supplemented groups during pre-conception and pregnancy (28 weeks gestation), and were reflected in higher cord blood holotranscobalamin (holo-TC) levels compared to the placebo group. Neurodevelopmental outcomes in the B12 alone group (n = 21) were better than the placebo (n = 27) in cognition (p = 0.044) and language (p = 0.020) domains (adjusted for maternal baseline B12 levels). There was no difference in neurodevelopmental outcomes between the B12 + MMN (n = 26) and placebo group. Cord blood Brain Derived Neurotrophic Factor (BDNF) levels were highest in the B12 alone group, though not significant.Conclusion: Pre-conceptional vitamin B12 supplementation improved maternal B12 status and offspring neurodevelopment at 2 years of age. The usefulness of cord BDNF as a marker of brain development needs further investigation. Our results highlight the importance of intervening during pre-conception.


2021 ◽  
Vol 12 (2) ◽  
pp. 212-118
Author(s):  
Prajakta N. Dongare ◽  
Tejashri B. Kadu ◽  
Ashish L. Pohane ◽  
Sachin J. Dighade ◽  
Priyadarshani G. Patil

Taraxacum officinale (dandelion), a member of the Asteraceae family, commonly found in the temperate zone of the Northern hemisphere, is the perennial herb, forming a rosette leaf, golden yellow flowers that bloom year round. Dandelion leaves, roots and flowers is used in many traditional and modern herbal medicinal systems. On phytochemical investigation, Dandelion herb contains one or more vital phytochemical constituents. Similarly Among the most important compounds in dandelion Contains sesquiterpene lactones which is a bitter element, principally contains taraxacin and taraxacerin, which is principally important in mechanism of liver functions related with hepatoprotective action. Besides that result of the phytochemical investigation revealed the presence of sterols, phenolic acids, flavonoids, that have been shown to be associated with numerous pharmacological effects such as Antioxidants, anti immflammatory, antidiabetics, antitumor activity. Along with that the Dandelion leaves are a high efficient source of vitamins and minerals, including beta carotene, non-provitamin A carotenoids, xanthophylls, chlorophyll, vitamins C and D, many of the B-complex vitamins, choline, iron, silicon, magnesium, sodium, potassium, zinc, manganese, copper, and phosphorous which is also useful as a several nutritive action. This review will point out areas for future research of phytochemicals containing Taraxacum officinale where they shows more effective against various ailments and shows recent effective pharmacological activity


Author(s):  
Jacob Nosewicz ◽  
Natalie Spaccarelli ◽  
Kristen M. Roberts ◽  
Phil A. Hart ◽  
Jessica A. Kaffenberger ◽  
...  
Keyword(s):  

2021 ◽  
Vol 9 (11) ◽  
Author(s):  
Yethindra Vityala ◽  
Aliya Kadyrova ◽  
Shirin Zhumabaeva ◽  
Aizhan Bazarbaeva ◽  
Sagynali Mamatov

2021 ◽  
Author(s):  
Fatma Nur Parin

Vitamins are regarded as vital nutrients because, when combined, they performed hundreds of functions in the body. They strengthen bones, heal wounds, and boost your immune system. In addition, they transform food into energy and heal cellular damage. In this regard, B-complex vitamins, such as thiamine, riboflavin, and niacin are soluble vitamins that serve as coenzymes in energy metabolism enzymatic activities which building blocks of a healthy body. However, B-complex vitamins are sensitive to light, pH conditions, and temperature. Consequently, they must be encapsulated before they may be used in pharmaceuticals. Recently, it is mainly focused on reducing drug degradation or loss, increase drug bioavailability, limit adverse effects, and improve drug accumulation in the targeted location. To maintain optimum bioavailability during a defined term of therapy, the fraction of drug dosage released from a controlled release product must be significant enough to adjust for the quantity of active drug metabolized and/or eliminated from the body over the same period. Drug release systems also aim to increase the effectiveness of the drug and treat the damaged area. In this chapter, it is aimed to study the production of the vitamin-loaded polymer systems in various forms, such as micro/nanoparticles, micelle, hydrogel, liposome, and nanofiber, as well as release studies in pharmaceutical and biomedical applications.


2021 ◽  
Vol 10 (7) ◽  
pp. e6510716255
Author(s):  
Juliana Cristina Castro ◽  
Márcia Maria dos Anjos ◽  
Andressa Hoinatski ◽  
Suellen Jensen Klososki ◽  
Jane Martha Graton Mikcha ◽  
...  

The aim of this study was developing formulations of H. undatus Haw. jam with pulp and peel, as well as evaluating nutritional compounds and texture properties through sensorial, instrumental, physical, biochemical and microbiological analyses of the final product. The fruit were selected, sanitized, pulped and grinded, and the formulations with different concentrations of pulp and peel (0 – 100%) were developed and evaluated. Microbiological evaluation showed that the formulations are in accordance with the current legislation. The increase in peel concentration in the jam formulations resulted in better consumer acceptance and higher concentration of phenolic compounds, antioxidants and B complex vitamins, such as B1, B5 and B6. In addition, it gave the jams acceptable and pleasant sensorial characteristics and texture.  Adding peel to the formulations enabled us to make total use of the fruit, with no waste, besides making the coproduct richer in compounds that are beneficial to consumers’ health.


2021 ◽  
Vol 190 ◽  
pp. 105322
Author(s):  
Nemanja M. Jovanovic ◽  
Uros Glavinic ◽  
Biljana Delic ◽  
Branislav Vejnovic ◽  
Nevenka Aleksic ◽  
...  

Author(s):  
Yethindra Vityala ◽  
Shirin Zhumabaeva ◽  
Baktygul Imankulova ◽  
Alina Kurmanalieva ◽  
Sagynali Mamatov

A 42-year-old male patient was diagnosed with coronavirus disease 2019. His symptoms improved 2 weeks after lopinavir therapy (400 mg every 12 hours). However, he was subsequently diagnosed with complete anosmia. Magnetic resonance brain imaging showed no abnormalities. We prescribed B-complex vitamins and olfactory training. Forty days later, he recovered.


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