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Quinoxaline is a versatile heterocyclic moiety that possesses a wide range of biological activities. Therefore, many researchers have been performing the synthesis of quinoxaline
derivatives on a daily basis. In addition, high demands for their synthesis often result in an
increased generation of different waste chemicals. However, to minimize the utilization and
generation of toxic organic substances, the present review focuses on the various green synthetic approaches for the synthesis of quinoxaline and its derivatives. Moreover, due to the
quick manufacturing of novel medications using a quinoxaline scaffold, multiple study reports
are published in a short period of time. Therefore, to fully comprehend the current state of the
quinoxaline scaffold in medicinal chemistry, it is necessary to combine recent findings with
previous understanding. Besides, compared to conventional methods, these green methods
minimize the use and generation of harmful chemicals and improve reaction efficiency in terms of product yields,
purity, energy consumption, and post-synthetic procedures. Therefore, in this review, we have attempted to shed
light on various green synthetic strategies leading to the synthesis of quinoxaline scaffold and its derivatives, such
as ultrasound irradiation, microwave irradiation, grindstone technique, environmentally benign solvents/catalysts
based, and reactant immobilized on a solid support, etc.