EXAMPLES OF PROHIBITED BANKING

The banking business that you should not conduct in Islamic banks is in the matter of exchange, including the exchange on the basis of the deferred price and the discount of commercial papers. Also, if the exchange contract does not meet its legal conditions, then he signs a contract in one of the two types of usury Al-Fadl or Al-Nasee’ah usury, or both as it will be explained, if he wishes. God, and perhaps the wisdom behind the prohibition of usury of an-Naseeh arising from the sale of cash for money other than its kind, when the forward factor in the price is taken into account, was not noticed by many to the extent that some were overwhelmed by surprise and astonishment when they learned that the Shari’a forbade this form of transaction.The paper is begins with the definition of parallel exchange and its legal adaptation and a statement of the pillars and conditions of the exchange contract and exchange work in contemporary Islamic banks . It was concluded that it is not permissible to deal with the exchange at the forward rate .

Myocardial Energy Response to Glyceryl Trinitrate: Physiology Revisited

Objective: Although intravenous nitrates are commonly used in clinical medicine, they have been shown to increase myocardial oxygen consumption and inhibit complex IV of the electron transport chain. As such we sought to measure whether myocardial energetics were impaired during glyceryl trinitrate (GTN) infusion.Methods: 10 healthy volunteers underwent cardiac magnetic resonance imaging to assess cardiac function and 31phosphorus magnetic resonance spectroscopy to measure Phosphocreatine/ATP (PCr/ATP) ratio and creatine kinase forward rate constant (CK kf) before and during an intravenous infusion of GTN.Results: During GTN infusion, mean arterial pressure (78 ± 7 vs. 65 ± 6 mmHg, p < 0.001), left ventricular (LV) stroke work (7,708 ± 2,782 vs. 6,071 ± 2,660 ml mmHg, p < 0.001), and rate pressure product (7,214 ± 1,051 vs. 6,929 ± 976 mmHg bpm, p = 0.06) all fell. LV ejection fraction increased (61 ± 3 vs. 66 ± 4%, p < 0.001), with cardiac output remaining constant (6.2 ± 1.5 vs. 6.5 ± 1.4 l/min, p = 0.37). Myocardial PCr/ATP fell during GTN infusion (2.17 ± 0.2 vs. 1.99 ± 0.22, p = 0.03) with an increase in both CK kf (0.16 ± 0.07 vs. 0.25 ± 0.1 s−1, p = 0.006) and CK flux (1.8 ± 0.8 vs. 2.6 ± 1.1 μmol/g/s, p = 0.03).Conclusion: During GTN infusion, despite reduced LV stroke work and maintained cardiac output, there was a 44% increase in myocardial ATP delivery through CK. As PCr/ATP fell, this increase in ATP demand coincided with GTN-induced impairment of mitochondrial oxidative phosphorylation. Overall, this suggests that while GTN reduces cardiac work, it does so at the expense of increasing ATP demand beyond the capacity to increase ATP production.

A computer-aided method for controlling chemical resistance of drugs using RRKM theory in the liquid phase

The chemical resistance of drugs against any change in their composition and studying the rate of multiwell-multichannel reactions in the liquid phase, respectively, are the important challenges of pharmacology and chemistry. In this article, we investigate two challenges together through studying drug stability against its unimolecular reactions in the liquid phase. Accordingly, multiwell-multichannel reactions based on 1,4-H shifts are designed for simplified drugs such as 3-hydroxyl-1H-pyrrol-2(5H)-one, 3-hydroxyfuran-2(5H)-one, and 3-hydroxythiophen-2(5H)-one. After that, the reverse and forward rate constants are calculated by using the Rice Ramsperger Kassel Marcus theory (RRKM) and Eckart tunneling correction over the 298–360 K temperature range. Eventually, using the obtained rate constants, we can judge drug resistance versus structural changes. To attain the goals, the potential energy surfaces of all reactions are computed by the complete basis set-quadratic Becke3 composite method, CBS-QB3, and the high-performance meta hybrid density functional method, M06-2X, along with the universal Solvation Model based on solute electron Density, SMD, due to providing more precise and efficient results for the barrier heights and thermodynamic studies. To find the main reaction pathway of the intramolecular 1,4-H shifts in the target molecules, all possible reaction pathways are considered mechanistically in the liquid phase. Also, the direct dynamics calculations that carry out by RRKM theory on the modeled pathways are used to distinguish the main reaction pathway. As the main finding of this research, the results of quantum chemical calculations accompanied by the RRKM/Eckart rate constants are used to predict the stability of drugs. This study proposes a new way to examine drug stability by the computer-aided reaction design of target drugs. Our results show that 3-hydroxyfuran-2(5H)-one based drugs are the most stable and 3-hydroxythiophen-2(5H)-one based drugs are more stable than 3-hydroxy-1H-pyrrol-2 (5H)-one based drugs in water solution.

Term structure modeling under volatility uncertainty

In this paper, we study term structure movements in the spirit of Heath et al. (Econometrica 60(1):77–105, 1992) under volatility uncertainty. We model the instantaneous forward rate as a diffusion process driven by a G-Brownian motion. The G-Brownian motion represents the uncertainty about the volatility. Within this framework, we derive a sufficient condition for the absence of arbitrage, known as the drift condition. In contrast to the traditional model, the drift condition consists of several equations and several market prices, termed market price of risk and market prices of uncertainty, respectively. The drift condition is still consistent with the classical one if there is no volatility uncertainty. Similar to the traditional model, the risk-neutral dynamics of the forward rate are completely determined by its diffusion term. The drift condition allows to construct arbitrage-free term structure models that are completely robust with respect to the volatility. In particular, we obtain robust versions of classical term structure models.

Carry Trade, Exchange Rates, and the Balance-of-Payments

This paper presents a partial equilibrium model that integrates interest rate arbitrage with the balance-of-payments constraint to determine the real exchange rate. The sequential logic is the following: (i) carry-trade determines the term premium, with the spot rate showing greater volatility than the forward rate, (ii) uncovered interest rate parity determines the spot rate based on the real exchange rate consistent with a financial constraint, defined as a stable ratio of foreign reserves to foreign debt; and (iii) the trade balance consistent with the financial constraint determines the long-run real exchange rate for a given ratio of domestic to foreign income.

On the Structural Constraint and Motion of 3-PRS Parallel Kinematic Machines

This paper presents a consistent analytic kinematic formulation of the 3-PRS parallel manipulator (PM) with a parasitic motion by embedding the velocity level structural constraint equation into the motion expression. Inverse rate kinematics (IRK) is solved with a simple constraint compatible velocity profile, which is obtained by projecting the instantaneous restriction space onto the motion space. Moreover, the systematic method to reveal the parasitic motion is introduced. Thus, the parasitic terms are automatically identified from the main motions. Unlike the usual approach, this study does not consider any explicit parasitic motion expression. Consequently, the derivation of constraint compatible input velocity, which comprises the parasitic term, is simplified. To incorporate the parasitic motion into the task velocity, constraint Jacobian of the manipulator is analytically obtained first. The manipulator Jacobian is extended to incorporate the passive joint’s information apart from the active joints and structural constraint. Hence, the dimension of the Jacobian matrix used to solve IRK is 9 × 6. The validity of the IRK is proved by the Bordered Gramian based forward rate kinematics (FRK). Then, an accurate numerical integration, RK4, is applied to the joint velocity of IRK to obtain the manipulator’s joint values. Consequently, the moving plate’s pose is obtained via forward position kinematics computed using integrated active and passive joint values for validation. The projection matrix used to get compatible constraint motion adjusts our input velocity and makes it compatible with the structural constraint policy, and the parasitic motion is embedded easily. Thus, an explicit formulation of the parasitic motion equation is not required, as the usual practice. Finally, the study presented numerical simulations to show the validity of the outlined resolutions. This paper’s result and analysis can be uniformly applied to other parallel manipulators with less than 6 DoFs.

CARA: A Congestion-Aware Routing Algorithm for Wireless Sensor Networks

Congestion control is one of the key research topics in relation to the routing algorithms of wireless sensor networks (WSNs). In this paper, we propose a congestion-aware routing algorithm (CARA) for unlimited-lifetime wireless sensor networks by integrating the geographic distance and traffic load of sensor nodes. The algorithm takes alleviating congestion as the primary purpose and considers the traffic of the node itself and local network traffic. According to the geographic distance between nodes, CARA defines four decision parameters (node load factor, forward rate, cache remaining rate, and forward average cache remaining rate), selecting the best node as the next-hop through the multi-attribute decision-making method. Compared with the two existing algorithms for congestion control, our simulation results suggest that the CARA algorithm alleviates network congestion and meets reasonable network delay and energy consumption requirements.