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2022 ◽  
pp. 1-6
Author(s):  
Connor Fitz-Gerald ◽  
David Kieser

<b>Background</b> The objective of this article is to describe for the first time a case of 90<sup>°</sup> spin out of a mobile bearing unicompartmental knee arthroplasty (UKA) polyethylene insert. In this report, we present a 57-year-old gentleman with a medial compartment UKA for osteoarthritis in 2017 who developed dislodgement and 90<sup>°</sup> rotation subsequent to traumatic injury when he was involved in a bus crash and impacted the anterolateral knee sustaining a valgus type injury 1 week postoperatively. Following the injury, he reported medial knee pain and a sensation of something moving within the joint. He was initially managed conservatively and progressed to full weight bearing; however, he experienced intermittent symptoms of catching and blocking of the joint, as well as medial knee swelling, that inhibited his ability to perform activities involving walking, kneeling, or pivoting. Imaging taken in 2018 show a 90° rotation of the polyethylene insert. These images showed the longitudinal metallic marker on the insert facing in an anteroposterior direction as opposed to the normal medial-lateral orientation. Failing conservative management, he presented to our clinic in 2019 and proceeded for revision of his UKA. Intraoperatively, his insert was reviewed and seen to easily spin on axis. The liner was therefore removed and upsized from a size 5 medium to a size 7 medium insert which provided excellent stability and stopped any further spinning. He has done tremendously well since the operation and reports full range of motion and no concerns. In patients with a history of pain, swelling, or locking following a UKA, it would be prudent to consider insert spinning, as well as the more common dislocation, through confirming the orientation of the metallic insert marker. Revision surgery to correct the spinning defect has proven effective with good resolution of symptoms and return to full range of motion.


2022 ◽  
Author(s):  
Yosra Saad ◽  
Mohamed Hichem Gazzah ◽  
Karine Mougin ◽  
Marwa Selmi ◽  
Hafedh Belmabrouk

Abstract The coronavirus (COVID-19) pandemic has put the entire world at risk and caused an economic downturn in most countries. This work provided theoretical insight into a novel fiber optic based plasmonic biosensor that can be used for sensitive detection of SARS-CoV-2. The aim was always to achieve reliable, sensitive and reproducible detection. The proposed configuration is based on Ag–Au alloy nanoparticles films covered with a layer of graphene which promotes the molecular adsorption and a thiol-tethered DNA layer as a ligand. Here the combination of two recent approaches in a single configuration is very promising and can only lead to considerable improvement. We have theoretically analyzed the sensor performance in terms of sensitivity and resolution. To highlight the importance of the new configuration, a comparison was made with two other sensors. One is based on gold nanoparticles incorporated into a host medium, the other is composed of a bimetallic Ag-Au layer in the massive state. The numerical results obtained has been validated and show that the proposed configuration offers better sensitivity (7100 nm\RIU) and good resolution (figure of merit; FOM=38.88Tand signal-to-noise ratio; SNR=0.388). In addition, a parametric study was performed such as the graphene layers number and the size of the nanoparticles.


2022 ◽  
Vol 75 (1) ◽  
Author(s):  
Karynne Borges Cabral ◽  
Cristiane Chagas Teixeira ◽  
Julianna Malagoni Cavalcante Oliveira ◽  
Jacqueline Andreia Bernardes Leão Cordeiro ◽  
Keila Cristianne Trindade da Cruz ◽  
...  

ABSTRACT Objectives: to evaluate a pediatric risk evaluation and classification service in the aspects of structure, process, and outcome. Methods: a cross-sectional, descriptive, and exploratory study in which qualitative data complement the results. Data collection by non-participant observation, interview, and consultation of medical records. Results: we observed two hundred and four visits. The service works in a makeshift room and without privacy. The nurses did not use various materials/equipment available for evaluation, rarely performed a physical examination, used the interview most of the time, and did not consult the protocol. Parents/companions received no information, and medical records showed incomplete records. Nurses classified 69.1% of the children as non-emergency. The most frequent outcome of the visits was discharge. Conclusions: the service showed weaknesses in the physical structure, in the risk classification process, and the outcomes, but it presents a good resolution in the assistance. We recommend a revision in the protocol used and sensitize nurses about the work process and communication with parents/companions.


2021 ◽  
Author(s):  
Andreas Petzold ◽  
Valerie Thouret ◽  
Christoph Gerbig ◽  
Andreas Zahn ◽  
Martin Gallagher ◽  
...  

&lt;p&gt;IAGOS (www.iagos.org) is a European Research Infrastructure using commercial aircraft (Airbus A340, A330, and soon A350) for automatic and routine measurements of atmospheric composition including reactive gases (ozone, carbon monoxide, nitrogen oxides, volatile organic compounds), greenhouse gases (water vapour, carbon dioxide, methane), aerosols and cloud particles along with essential thermodynamic parameters. The main objective of IAGOS is to provide the most complete set of high-quality essential climate variables (ECV) covering several decades for the long-term monitoring of climate and air quality. The observations are stored in the IAGOS data centre along with added-value products to facilitate the scientific interpretation of the data. IAGOS began as two European projects, MOZAIC and CARIBIC, in the early 1990s. These projects demonstrated that commercial aircraft are ideal platforms for routine atmospheric measurements. IAGOS then evolved as a European Research Infrastructure offering a mature and sustainable organization for the benefits of the scientific community and for the operational services in charge of air quality and climate change issues such as the Copernicus Atmosphere Monitoring Services (CAMS) and the Copernicus Climate Change Service (C3S). IAGOS is also a contributing network of the World Meteorological Organization (WMO).&lt;/p&gt; &lt;p&gt;IAGOS provides measurements of numerous chemical compounds which are recorded simultaneously in the critical region of the upper troposphere &amp;#8211; lower stratosphere (UTLS) and geographical regions such as Africa and the mid-Pacific which are poorly sampled by other means. The data are used by hundreds of groups worldwide performing data analysis for climatology and trend studies, model evaluation, satellite validation and the study of detailed chemical and physical processes around the tropopause. IAGOS data also play an important role in the re-assessment of the climate impact of aviation.&lt;/p&gt; &lt;p&gt;Most important in the context of weather-related research, IAGOS and its predecessor programmes provide long-term observations of water vapour and relative humidity with respect to ice in the UTLS as well as throughout the tropospheric column during climb-out and descending phases around airports, now for more than 25 years. The high quality and very good resolution of IAGOS observations of relative humidity over ice are used to better understand the role of water vapour and of ice-supersaturated air masses in the tropopause region and to improve their representation in numerical weather and climate forecasting models. Furthermore, CAMS is using the water vapour vertical profiles in near real time for the continuous validation of the CAMS atmospheric models. &lt;/p&gt;


Author(s):  
S. M. Ariful Islam ◽  
Christine A. Powell ◽  
Martin C. Chapman

Abstract Three-dimensional P- and S-wave velocity (VP and VS) models are determined for the crust containing the main aftershock cluster of the 2011 Mineral, Virginia, earthquake using local earthquake tomography. The inversion uses a total of 5125 arrivals (2465 P- and 2660 S-wave arrivals) for 324 aftershocks recorded by 12 stations. The inversion volume (22 × 20 × 16 km) is completely contained within the Piedmont Chopawamsic metavolcanic terrane. The models are well resolved in the central portion of the inversion volume in the depth range 1–5 km; good resolution does not extend to the hypocenter depth of the mainshock. Most aftershocks are located within a northeast-trending, southeast-dipping region containing negative VP anomalies, positive VS anomalies, and VP/VS ratios as low as 1.53. These velocity results strongly argue for the presence of quartz-rich rocks, which we attribute to either the presence of a giant quartz vein system or metamorphosed orthoquarzite sandstones originally deposited on the Laurentian passive margin and subsequently incorporated into the Chopawamsic thrust sheets during island arc collision in the Taconic orogeny.


2021 ◽  
Author(s):  
Nagendra Prasad Yadav ◽  
Guozhen Hu ◽  
Yi-Fan Wang

Abstract Recently there has been an increasing demand for terahertz technology especially in imaging. In the past few decades, the applications of terahertz (THz) imaging technology have seen significant developments in the fields of biology, medical diagnosis, food safety, and nondestructive testing. The medical and semiconductor industry has always attracted significant attention worldwide. In particular, the importance of real and perfect inspection technologies has been growing due to an increasing demand for improving the quality of life and developing industries. This paper presents the research of THz technology with super-resolution THz imaging in transmission mode on four types of different samples. We have reported transmission measurement at different THz frequency of each sample. The butterfly sample used super-resolution THz imaging. The THz super-resolution is obtained excellent at 1.8 THz, it is near about 1 micrometer. A good resolution images have been obtained. This new THz super-resolution techniques can apply in medical and security purposes. Further applications will be reported in coming papers.


INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (09) ◽  
pp. 65-69
Author(s):  
Atul Sherje ◽  
◽  
Subhash Dhende ◽  
Mayur Yergiri

An isocratic liquid chromatographic method with UV detection at 230 nm is described for simultaneous determination of ceftriaxone sodium and salbutamol in bulk. Chromatographic separation of the two drugs was achieved on an Inertsil ODS© C18 (250 × 4.6 mm, 5 μ) using a mobile phase consisting of 50 mM potassium dihydrogen orthophosphate and methanol (77:23 %V/V) adjusted to pH 7.0 with triethylamine at a fl ow rate of 1.0mL min-1. The optimum separation was achieved in less than 10 minutes. The developed liquid chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. The method was validated as per ICH guidelines.


Author(s):  
Ramreddy Godela ◽  
Sowjanya G

A trouble-free, simple, specific and highly sensitive stability indicating phase HPLC method was developed for concurrent assessment of Daclatasvir and Sofosbuvir in pure and in their combined tablet formulation. An effectual separation was accomplished by using XDB Phenyl (250 x 4.6mm, 5µ,100 A0) column, mobile phase composition of Acetonitrile: buffer(0.1%v/v Trifluoroaceticacid in water) (50:50 v/v) and isocratic elution at a flow rate of 1ml/min and detection wavelength of 275nm. The extreme stress conditions like hydrolysis with acid and base, peroxide oxidation, thermal decomposition were used as per ICH specifications to assess the stability of the analytes in bulk and dosage forms. The retention times of Daclatasvir and Sofosbuvir were found at 2.8 and 3.7min respectively. The proposed method has linear response in the concentration ranges from 12 to 36µg/ml and 80 to 240 µg/ml for Daclatasvir and Sofosbuvir respectively. The detection and quantification limits calculated as 2.5μg/ml and 7.8μg/ml for DCL, 5.2μg/ml and 15.8μg/ml SOF respectively. All the method validation parameters were met the acceptance limits of Q2 specifications of ICH procedures. The degradation products produced by forced degradation studies were have good resolution from Daclatasir and Sofosbuvir peaks, which represents the methods stability. The proposed RP-HPLC method was highly sensitive, precise, stability indicating and economical. That’s why the method has the capacity to employ in the pharmaceutical manufacturing of Daclatasvir and Sofosbuvir and routine analysis in quality control department.


Author(s):  
Noopur K. Gandhi ◽  
Sindhu B. Ezhava

The applicability of a quality by design (QbD) approach for the development of a sensitive and selective stability indicating reversed-phase high performance liquid chromatography (RP-HPLC) method for the estimation of Ivabradine and Metoprolol was investigated. Design of experiments using a fractional factorial design approach was used for method development. Fifteen experimental runs were performed to optimize the chromatographic conditions like mobile phase, flow rate and column oven temperature. Mobile phase composition was optimized by changing Acetonitrile composition ranging between 13 and 17% v/v, Flow rate from 0.6 to 1.0 ml/min and temperature between 30 to 50 0C. The optimized method produced sharp peaks with good resolution (>2) for Metoprolol and Ivabradine with retention times of 3.3 and 9.2 min, respectively. The experimental data revealed that volume of Acetonitrile in mobile phase was prominently affecting the Retention time, Resolution & tailing factor of both the drugs. Normal probability plots revealed that the residual and predicted data fall approximately on a straight line, indicating that the experimental error for these studies was evenly distributed suggesting that the model could be used to navigate the design space. This approach is useful to expedite method development and optimization activities in analytical laboratories.


2021 ◽  
Author(s):  
Huijuan Shen ◽  
Yaode Wang ◽  
Liang Cao ◽  
Ying Xie ◽  
Lu Wang ◽  
...  

Abstract The micro-stripe structure was prepared by laser interference induced forward transfer (LIIFT) technique, composed of Ag nano-particles (NPs). The effects of the film thickness with the carbon nano-particles mixed polyimide (CNPs@PI), Ag film thickness, and laser fluence were studied on the transferred micro-stripe structure. The periodic Ag micro-stripe with good resolution was obtained in a wide range of CNPs@PI film thickness from ~ 0.5 μm to ~ 1.0 μm for the Ag thin film ~ 20 nm. The distribution of the Ag NPs composing the micro-stripe was compact. Nevertheless, the average size of the transferred Ag NPs was increased from ~ 41 nm to ~ 197 nm with the change of the Ag donor film from ~ 10 nm to ~ 40 nm. With the increase of the laser fluence from 102 mJ•cm-2 to 306 mJ•cm-2 per-beam, the transferred Ag NPs became aggregative, improving the resolution of the corresponding micro-stripe. Finally, the transferred Ag micro-stripe exhibited the significant surface enhanced Raman scattering (SERS) property for rhodamine B (RhB). While the concentration of the RhB reached 10-10 mol•L-1, the Raman characteristic peaks of the RhB were still observed clearly at 622 cm-1, 1359 cm-1, and 1649 cm-1. These results indicate that the transferred Ag micro-stripe has potential application as a SERS chip in drug and food detection.


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