Nanoemulsion is the major vehicle for delivering different types of drugs, nucleic acids, and imaging agents. Due to their attractive properties, it has been extensively used for diagnostics of cancer therapy and imaging. However, nanoemulsion is designed through multiple functions by modifications in surface and encapsulation of active compounds against cancer. In nanoemulsion, the surface alteration can be changed by targeting the surface charge, a targeting ligand. The core of the emulsion can be loaded with drugs, imaging agents, and contrast agents. In this chapter, the application of nanoemulsion against specifically liver and gastric cancer is explored briefly. The major focuses on the severity of cancer, multifunctional nature of respective drug-loaded nanoemulsions, how to defeat the physiological hurdles, targeted and non-targeted delivery of nanoemulsion, clinical and preclinical studies are discussed with trending examples from the review of the literature and future perspectives.