In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of ribonuclease A family member 4, encoded by RNASE4, in cancer of the vulva. RNASE4 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).