nitric oxide production
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2022 ◽  
Vol 185 ◽  
pp. 111814
Author(s):  
Lu Sun ◽  
Shufen Luo ◽  
Hu Huali ◽  
Hongsheng Zhou ◽  
Yintong Zhang ◽  
...  

2022 ◽  
Vol 196 ◽  
pp. 113081
Author(s):  
Wei-Wei Yu ◽  
Jin-Tao Ma ◽  
Juan He ◽  
Zheng-Hui Li ◽  
Ji-Kai Liu ◽  
...  

Author(s):  
Hui Wang ◽  
Ze Yuan ◽  
Bianbian Wang ◽  
Bochuan Li ◽  
Huizhen Lv ◽  
...  

Background: Vascular endothelial cells are critical for maintaining blood pressure (BP) by releasing biologically active molecules, such as nitric oxide. A non-endothelial cell resident matricellular protein, COMP (cartilage oligomeric matrix protein), plays a pivotal role in maintaining cardiovascular homeostasis, but little is known about its regulatory effect on BP. Methods: Mice were infused with AngII (angiotensin II; 450 ng/kg per minute) for 3 days via an osmotic minipump, and BP was monitored by a tail-cuff system. Second-order mesenteric arteries were isolated from mice for microvascular tension measurement. Nitric oxide was detected by an electron paramagnetic resonance technique. Small-interfering RNA transfection, co-immunoprecipitation, bioluminescence resonance energy transfer assays, and patch-clamp electrophysiology experiments were used for further detailed mechanism investigation. Results: COMP −/− mice displayed elevated BP and impaired acetylcholine-induced endothelium-dependent relaxation compared with wild-type mice with or without AngII. Inhibition of eNOS (endothelial nitric oxide synthase) abolished the difference in endothelium-dependent relaxation between wild-type and COMP −/− mice. Furthermore, COMP directly interacted with the C-terminus of Piezo1 via its C-terminus and activated the endogenous Piezo1 currents, which induced intracellular Ca 2+ influx, Ca 2+ /calmodulin-dependent protein kinase type II and eNOS activation, and nitric oxide production. The Piezo1 activator, Yoda1, reduced the difference in endothelium-dependent relaxation and BP in wild-type and COMP − /− mice. Moreover, COMP overexpression increased eNOS activation and improved endothelium-dependent relaxation and BP. Conclusions: Our study demonstrated that COMP is a novel Piezo1 regulator that plays a protective role in BP regulation by increasing cellular Ca 2+ influx, eNOS activity, and nitric oxide production.


2022 ◽  
Vol 193 ◽  
pp. 112973
Author(s):  
Wen-Chao Tu ◽  
Lin-Fen Ding ◽  
Li-Yan Peng ◽  
Liu-Dong Song ◽  
Xing-De Wu ◽  
...  

Author(s):  
Andy Wijaya ◽  
Yi Wang ◽  
Dan Tang ◽  
Yuan Zhong ◽  
Boyan Liu ◽  
...  

Nitric oxide (NO) is an exceptional endogenous biological molecule gas that mediates and regulates physiological and pathological processes in the human body. However, its synthesis process is impaired during athero-progression...


In Vivo ◽  
2021 ◽  
Vol 36 (1) ◽  
pp. 227-232
Author(s):  
TAKASHI TANIKAWA ◽  
MASASHI KITAMURA ◽  
YASUHIRO HAYASHI ◽  
TAKAMI YOKOGAWA ◽  
YUTAKA INOUE

2021 ◽  
pp. 1-5
Author(s):  
José Marreiro de Sales-Neto ◽  
Juliane Santos de França da Silva ◽  
Deyse Cristina Madruga Carvalho ◽  
Éssia de Almeida Lima ◽  
Luiz Henrique Agra Cavalcante-Silva ◽  
...  

Marine Drugs ◽  
2021 ◽  
Vol 20 (1) ◽  
pp. 5
Author(s):  
Xiaoya Qin ◽  
Jiguo Huang ◽  
Dexiong Zhou ◽  
Wenxiu Zhang ◽  
Yanjun Zhang ◽  
...  

Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC50 values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.


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