ohio river basin
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2021 ◽  
Vol 254 ◽  
pp. 106962
Author(s):  
Yawen Huang ◽  
Bo Tao ◽  
Zhu Xiaochen ◽  
Yanjun Yang ◽  
Liang Liang ◽  
...  

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S152-S153
Author(s):  
Kathryn Majdick ◽  
Keaton Kaye ◽  
Mahmoud Shorman

Abstract Background Blastomycosis is a systemic infection, well known to regions of the Southeastern and Ohio River Basin in the United States. Inhalation of the dimorphic fungus most often causes pulmonary manifestations. Hematogenous dissemination can affect various organs in immunocompromised hosts. Central Nervous System (CNS) involvement is a rare manifestation of Blastomycosis infection, accounting for 5%–10% of extrapulmonary involvement. It is important to diagnosis early and treat due to the increased morbidity in high-risk patients. Methods Our study retrospectively reviewed cases from a Tertiary Care Facility in East Tennessee from 2011 to 2018 with the diagnosis of CNS Blastomycosis. Data collection included demographics, risk factors, varied clinical presentation, methods of diagnosis, treatment plans and outcomes. Results Total of 8 CNS Blastomycosis cases were identified. Detailed demographics are presented in Table 1. The average age was 52 years, 7 (87.5%) were male. 6 (75%) were classified as immunocompromised. 6 of the 8 cases were tested for HIV, all of which were negative. MRI brain imaging was utilized in 7 (87.5%) cases, which demonstrated lesion enhancements, Table 2 and Images 1 and 2. CSF was collected in 6 (75%) patients. 5 patients (62%) presented with neurological complaints. All patients received Liposomal Amphotericin B (LAmpB), followed by a prolonged course of azoles. 5 (62%) developed acute renal insufficiency after starting Amphotericin B. 2 (25%) died. Conclusion CNS Blastomycosis is a rare diagnosis with increased morbidity and mortality. Obtaining brain imaging in addition to lumbar puncture can help in timely diagnosis of CNS Blastomycosis. Treatment involves lipid formulation of Amphotericin B followed by oral azole therapy, preferably voriconazole. Renal insufficiency was a common finding after this treatment. A high level of suspicion is crucial for recognition of CNS Blastomycosis in endemic regions of the Southeastern and Ohio River Basin. Disclosures All authors: No reported disclosures.


2019 ◽  
Author(s):  
Mark Pyron ◽  
Meryl C. Mims ◽  
Mario M. Minder ◽  
Robert C. Shields ◽  
Nicole Chodkowski ◽  
...  

AbstractLong-term monitoring of species assemblages provides a unique opportunity to test hypotheses regarding environmentally-induced directional trajectories of freshwater species assemblages. We used 57 years of lockchamber fish rotenone and boat electrofishing survey data (1957-2014) collected by the Ohio River Valley Water Sanitation Commission (ORSANCO) to test for directional trajectories in taxonomy, trophic classifications, and life history strategies of freshwater fish assemblages in the Ohio River Basin. We found significant changes in taxonomic and trophic composition of freshwater fishes in the Ohio River Basin. Annual species richness varied from 31 to 90 species and generally increased with year. Temporal trajectories were present for taxonomic and trophic assemblages. Assemblage structure based on taxonomy was correlated with land use change (decrease in agriculture and increase in forest). Taxonomic assemblage structure was also correlated with altered hydrology variables of increased minimum discharge, decreased fall rate, and increased rise rate. Trophic composition of fish catch correlated with land use change (decrease in agriculture and increase in forest) and altered hydrology. Altered hydrology of increased minimum discharge, increased fall discharge, decreased base flows, and increased number of high pulse events was correlated with increased counts of herbivore-detritivores and decreased counts of piscivores and planktivores. We did not find directional changes in life history composition. We hypothesized a shift occurred from benthic to phytoplankton production throughout the basin that may have decreased secondary production of benthic invertebrates. This may also be responsible for lower trophic position of invertivore and piscivore fishes observed in other studies.


2018 ◽  
Vol 54 (11) ◽  
pp. 9321-9341 ◽  
Author(s):  
Katherine E. Schlef ◽  
Baptiste François ◽  
Andrew W. Robertson ◽  
Casey Brown

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