Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS2/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.

Nature of Electronic Excitations in Non-stoichiometric Quantum Dots

Colloidal quantum dots (QDs) have emerged as nanocrystalline semiconductors with tunable optoelectronic properties that have attracted attention for numerous commercial applications. While a significant amount of computational research has focused...

Synthesis and study of some properties of colloidal quantum dots of indium antimonide

Colloidal quantum dots of indium antimonide have been synthesized by a known technique. The shape and average diameters of quantum dots have been investigated by transmission electron microscopy using a transmission microscope. Controlling the size and shape of colloidal QDs provides information on the formation of the crystal structure of nanoparticles and their possible physical and optical properties. It has been found that InSb quantum dots are characterized by a polygonal shape. The results obtained for QDs correspond to the crystal lattice system of a semiconductor with a cubic crystal lattice structure. Elemental analysis of nanoparticles has been monitored by X-ray microanalysis. The experimental determination error was no more than one percent. The percentages of indium and antimony in QDs according to X-ray microanalysis data corresponded to the theoretical stoichiometry In: Sb = 1:1. Impurities of other elements constituted the level of trace amounts, which confirmed the chemical purity of the synthesized InSb QDs. The fluorescent properties of indium antimonide nanoparticles have been studied. It has been found that the luminescence intensity of InSb nanoparticles at room temperature is insignificant, which is in agreement with the literature data. The quantum yield does not exceed 1%, and the luminescence maximum lies in the range of 1040 nm.