zinc absorption
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2021 ◽  
Author(s):  
Solange E. Brandão ◽  
Geane M. Barbosa ◽  
Matheus C. Siqueira ◽  
Rafaela de O. A. Campos ◽  
Ana C. F. Dalsin ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4253
Author(s):  
Blerina Shkembi ◽  
Thom Huppertz

In this paper, we reviewed the role of dairy products in dietary zinc absorption. Dairy products can have a reasonable contribution for dietary zinc intake in Western diets, where dairy consumption is high. However, the co-ingestion of dairy products can also improve zinc absorption from other food products. Such improvements have been observed when dairy products (e.g., milk or yoghurt) were ingested together with food such as rice, tortillas or bread products, all of which are considered to be high-phytate foods with low inherent zinc absorption. For foods low in phytate, the co-ingestion of dairy products did not improve zinc absorption. Improved zinc absorption of zinc from high-phytate foods following co-ingestion with dairy products may be related to the beneficial effects of the citrate and phosphopeptides present in dairy products. Considering that the main dietary zinc sources in areas in the world where zinc deficiency is most prevalent are typically high in phytate, the inclusion of dairy products in meals may be a viable dietary strategy to improve zinc absorption.


Author(s):  
Pengxiu Dai ◽  
Yangou Lv ◽  
Xiaowen Gong ◽  
Jianye Han ◽  
Peng Gao ◽  
...  

Microsporum canis, a common pathogenic skin fungus, can cause dermatophytosis in humans and animals. Zinc is an important trace element and plays an important role in the growth and metabolism of fungi. Currently, the effects of zinc deficiency on growth, gene expression, and metabolic pathway have not been clarified in M. canis. Therefore, M. canis was cultured under zinc restriction, and RNA-Seq was conducted in this study. The growth of M. canis was severely inhibited, and many genes showed significant upregulation and downregulation in M. canis with zinc deficiency. Zinc deficiency could negatively affect the gene expression and biological metabolic pathway in M. canis. The zinc-responsiveness transcriptional activator (ZafA) gene was significantly upregulated and shared homology with Zap1. Thus, the ZafA gene might be the main transcription factor regulating M. canis zinc homeostasis. The ZafA gene knockout strain, ZafA-hph, was constructed via Agrobacterium tumefaciens-mediated transformation (ATMT) in M. canis for the first time to assess its function. In vitro growth ability, hair biodegradation ability, virulence test, and zinc absorption capacity in ZafA-hph and wild-type M. canis strains were compared. Results showed that the ZafA gene plays an important role in zinc absorption, expression of zinc transporter genes, and growth and pathogenicity in M. canis and can be used as a new drug target. Cutting off the zinc absorption pathway can be used as a way to prevent and control infection in M. canis.


Author(s):  
Manuel Ruz ◽  
Fernando Carrasco ◽  
Pamela Rojas ◽  
Juana Codoceo ◽  
Jorge Inostroza ◽  
...  

ABSTRACT Background Roux-en-Y gastric bypass (RYGBP) is known to reduce zinc absorption; the effects of vertical sleeve gastrectomy (SG) and its long-term implications on zinc absorption have not yet been studied. Objective The aim was to evaluate the effects of SG and RYGBP on zinc absorption and zinc status in premenopausal women with severe obesity up to 24 mo after surgery. Methods Twenty-six premenopausal women undergoing SG [BMI (in kg/m2): 37.3 ± 3.2] and 32 undergoing RYGBP (BMI: 42.0 ± 4.2) were studied. A series of anthropometric, dietary, and zinc status parameters (plasma and hair zinc), and the size of the exchangeable zinc pool (EZP), as well as percentage zinc absorption from a standardized dose using a stable isotope methodology were evaluated in the patients before the surgical procedure and at 12 and 24 mo after SG or RYGBP. SG patients received 15 mg and RYGBP received 25 mg of supplemental Zn/d. Results In premenopausal women, zinc absorption was decreased by 71.9% and 52.0% in SG and RYGBP, respectively, 24 mo postsurgery, compared with initial values. According to 2-factor repeated-measures ANOVA, time effect was significant (P = <0.0001), but not time × group interaction (P = 0.470). Plasma zinc below the cutoff point of 70 µg/dL increased from 0 to 15.4% and 38.1% in SG and RYGBP, respectively. Mean EZP was significantly reduced 24 mo after surgery, although no time × group interactions were observed. Hair zinc did not change across time or between groups. Conclusions Both SG and RYGBP have profound effects on zinc absorption capacity, which are not compensated for after 24 mo. Although zinc absorption reduction was similar in both types of surgeries, plasma zinc was more affected in RYGBP than SG, despite greater zinc supplementation in RYGBP. This trial was registered at http://www.isrctn.com as ISRCTN31937503.


Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 36
Author(s):  
Fen-Fen Liu ◽  
Md. Abul Kalam Azad ◽  
Zhi-He Li ◽  
Jing Li ◽  
Kai-Bin Mo ◽  
...  

The study aimed at determining the effect of different zinc (Zn) supplementation forms on Zn accumulation, activities of Zn-containing enzymes, gene expression of metallothionein (MT), and Zn transporters in piglets. Eighteen piglets were randomly divided into three groups: (a) a basal diet supplemented with 150 mg/kg Zn from Zn methionine (Zn-Met) in the feed (Zn-Met group), (b) a basal diet supplemented with 150 mg/kg Zn from Zn sulfate (ZnSO4) in the feed (ZnSO4, feed group), and (c) a basal diet supplemented with the same dose of Zn as in ZnSO4,feed group but in water (ZnSO4, water group). The results showed that Zn-Met added in feed and ZnSO4 dissolved in drinking water significantly improved (p < 0.05) the Zn concentration in liver and jejunum and the apparent digestibility of Zn in comparison with the ZnSO4 added in feed. In addition, dietary Zn supplementation as Zn-Met significantly increased (p < 0.05) the activity of alkaline phosphatase (AKP) in the jejunum of piglets in comparison with the ZnSO4, feed group. Furthermore, the Zn-Met and ZnSO4, water groups showed an improved total superoxide dismutase activity (T-SOD) in the ileum as compared to the ZnSO4, feed group. Meanwhile, the qPCR and western blot results showed that Zn-Met and ZnSO4 dissolved in drinking water increased the expression of MT in the jejunum in comparison with the ZnSO4 added in the piglets’ feed. However, different Zn supplementation forms had no effect on the mRNA expressions of Zip4 and ZnT1 transporters. In conclusion, Zn-Met added in feed and ZnSO4 dissolved in drinking water had higher bioavailability in piglets.


2020 ◽  
Vol 533 (4) ◽  
pp. 1004-1011
Author(s):  
Zhiqing Wang ◽  
Xinxin Li ◽  
Bing Zhou
Keyword(s):  

2020 ◽  
Vol 40 (suppl 1) ◽  
pp. 363-368
Author(s):  
Larissa Catelli Rocha TORRES ◽  
José Eduardo Pedroso Gomes do AMARAL ◽  
Solange Guidolin Canniatti-Brazaca

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 905-905
Author(s):  
Gregory Sclama ◽  
Diego Rose

Abstract Objectives Dietary phytate is a potent inhibitor of zinc absorption. Phytate levels of cereals can be reduced by basic household processing techniques such as soaking, germinating, and fermenting. The objective of this study was to model the potential of such techniques to reduce the burden of zinc deficiency in Malawi, where high-phytate maize is a dietary staple. Methods Using nationally representative household consumption data and food composition tables, we estimated daily phytate and zinc intakes for individuals in Malawi. We then applied a mathematical model of zinc absorption based on total dietary zinc and phytate to calculate the apparent absorbed zinc for each individual. Using the Cut-Point method described by the Institute of Medicine, we determined the proportion of each physiological group with absorbed zinc below their mean requirements. We then simulated the reduction in dietary phytate resulting from maize processing and estimated the new burdens of zinc deficiency. We estimated the impact at various coverage levels and compared the results against an alternative model using zinc-biofortified maize. Results Nationally, 34% of females age 14–18 and 23% of females over age 18 were at risk of zinc deficiency. Only 13% of women of childbearing age met the zinc requirement for pregnancy, while less than 4% met the requirement for breastfeeding. The burden of zinc deficiency was highest in the South where maize intake was highest. The simulation of phytate reduction from household processing found that with 40% coverage, the proportion of at-risk females age 14–18 fell below 23%, while the proportion over age 18 fell to 14%. The potential benefits were greatest in the South, where the proportion of women at risk was reduced by over a third. Biofortification also reduced zinc deficiency, however the modeled impact of processing was greater than biofortification for all regions and subgroups. Conclusions Household food processing techniques may be an important strategy to reduce the burden of zinc deficiency among vulnerable women in Malawi. These techniques are low-cost and not widely practiced at present. Behavior change interventions to promote them must consider culture, gender norms, and drivers of food preference. Food-based approaches such as these should be given greater attention in nutrition and health policy and programming. Funding Sources None.


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