neuropsychiatric lupus
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2021 ◽  
Vol 7 (2) ◽  
pp. 41-48
Author(s):  
Claudia Centurión-Wenninger

Cureus ◽  
2021 ◽  
Author(s):  
Yasser M Bawazir ◽  
Sami Bahlas ◽  
Ibtisam Jali ◽  
Deyaa A Mukhtar ◽  
Nujood Almohammmadi ◽  
...  

Genes ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 1172
Author(s):  
Dumitru A. Iacobas ◽  
Jing Wen ◽  
Sanda Iacobas ◽  
Chaim Putterman ◽  
Noa Schwartz

Neuropsychiatric manifestations of systemic lupus erythematosus (SLE), specifically cognitive dysfunction and mood disorders, are widely prevalent in SLE patients, and yet poorly understood. TNF-like weak inducer of apoptosis (TWEAK) has previously been implicated in the pathogenesis of neuropsychiatric lupus (NPSLE), and we have recently shown its effects on the transcriptome of the cortex of the lupus-prone mice model MRL/lpr. As the hippocampus is thought to be an important focus of NPSLE processes, we explored the TWEAK-induced transcriptional changes that occur in the hippocampus, and isolated several genes (Dnajc28, Syne2, transthyretin) and pathways (PI3K-AKT, as well as chemokine-signaling and neurotransmission pathways) that are most differentially affected by TWEAK activation. While the functional roles of these genes and pathways within NPSLE need to be further investigated, an interesting link between neuroinflammation and neurodegeneration appears to emerge, which may prove to be a promising novel direction in NPSLE research.


Cureus ◽  
2021 ◽  
Author(s):  
Ammar Farook Chapra ◽  
Fadi Khir ◽  
Ans Alamami ◽  
Khaled M Salem ◽  
Alhady Yusof

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 605.1-605
Author(s):  
A. Kyriakou ◽  
A. Chatzittofis ◽  
K. Parperis

Background:Previous studies have demonstrated that SLE patients have a higher risk of suicidal behaviour, including suicidal ideation, attempt and complete suicide (1,2). Data describing the SLE patients’ clinical characteristics and risk factors of suicidal behaviour are lacking.Objectives:To determine the magnitude of suicidal behaviour among SLE patients and to examine predictors associated with suicidal behaviour.Methods:According to the PRISMA guidelines, we conducted a systematic literature review of the online databases, PubMed/Medline, EMBASE, and Web of Science, from inception to December 2020 (Figure 1). Full-text original articles that examined the relationship between SLE patients with suicidal behaviour were eligible for our review. Two reviewers independently review articles to assess eligibility using the Newcastle-Ottawa Scale and the Joanna Briggs Institute tools. Systematic reviews, metanalysis, narrative review, case reports, case series, including less than 10 patients and conference abstracts, were excluded.Results:Of the 64 articles identified, 22 were relevant to the study question; cross-sectional (n=8) and prospective cohorts (n=6) were the most frequently retrieved studies. Among the 27106 SLE patients with SLE, 802 had suicidal behaviour (2.9%), and of those, 87.9% were female. Suicide attempt occurred in 573/802 (71.4%) and complete suicide in 18/802 (2,3%). Major depressive disorder (MDD) was the most frequently reported coexisting psychiatric condition associated with suicidal behavior, followed by psychosis and social phobia. Several clinical manifestations were linked to suicidal behaviour, particularly neuropsychiatric lupus, mucocutaneous, renal involvement and serositis. Further, high scores in disease activity and damage indices were associated with suicidal behaviour.Conclusion:Suicidal behavior in SLE patients was associated with MDD, NPSLE, active disease and damage. Awareness of these findings can guide clinicians to recognize suicide behavior promptly and prevent suicide attempts.References:[1]Hajduk A, Nowicka-Sauer K, Smoleńska Ż, Czuszyńska Z, Zdrojewski Z. Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus. Lupus. 2016 Feb;25(2):185-92. doi: 10.1177/0961203315603136.[2]Buji RI, Abdul Murad NA, Chan LF, Maniam T, Mohd Shahrir MS, Rozita M, Shamsul AS, Mohamad Hussain R, Abdullah N, Jamal R, Nik Jaafar NR. Suicidal ideation in systemic lupus erythematosus: NR2A gene polymorphism, clinical and psychosocial factors. Lupus. 2018 Apr;27(5):744-752. doi: 10.1177/0961203317742711.Figure 1.A PRISMA chart describing the inclusion/exclusion processDisclosure of Interests:None declared


2021 ◽  
Author(s):  
SAMILA COSTA PINHEIRO GUERRA BARROS ◽  
SÉRGIO MAMERI MEIRELES DE SOUZA ◽  
DIEGO RIVEROS LOGRADO ◽  
RENÊ LIMA PORTO ◽  
DAWTON YUKITO TORIGOE ◽  
...  

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