Abstract
Background – Anaemia continues to be a major public health problem among women of reproductive age (WRA). A thorough understanding of anaemia risk factors is necessary to design better interventions. This paper examines the determinants of anaemia among WRA in South Africa.Methods- We included baseline data from 480 women participating in the pilot-phase of a randomized controlled trial (HeLTI). We measured haemoglobin (Hb) status using the Hemocue. Plasma iron status markers (ferritin and soluble transferrin receptor (sTfR)), markers of inflammation (C-reactive protein (CRP)) and alpha-1-acid glycoprotein (AGP)) and retinol binding protein (RBP) were assessed using the multiplex method. We used multivariate logistic regression to describe associations with anaemia and structural equation modelling (SEM) to characterise direct and indirect pathways influencing haemoglobin concentrations.Results- The prevalence of anaemia, iron deficiency (ID), and iron deficiency anaemia (IDA) was 39.4%, 38.1% and 21.6% respectively. The multiple logistic regression showed that ID (OR: 2.62, 95% CI: 1.72, 3.98), iron deficiency erythropoiesis (IDE) (OR: 1.62, 95% CI: 1.07, 2.46), and elevated CRP (OR: 1.69, 95% CI: 1.04, 2.76), increased the odds of being anaemic. SEM analysis revealed Hb was directly and positively associated with adjusted ferritin (0.0031 per mg/dl; p≤0.001), and CRP (0.015 per mg/dl; p≤0.05), and directly and negatively associated with soluble transferrin receptor sTfR (-0.042 per mg/dl; p≤0.001). While contraception use had both a direct (0.34; p≤0.05) and indirect (0.11; p≤0.01) positive association with Hb. Additionally, chicken and beef consumption had a positive indirect association with Hb concentrations (0.15; p≤0.05) through adjusted ferritin.Conclusion-A key driver of anaemia in our setting is ID, however the presence of inflammation also increases the risk of anaemia. To address anaemia, interventions should aim to improve the diet quality of women, in particular access to iron rich foods. We recommend the use of multi-micronutrient supplements with a lower dose of iron and other micronutrients which would ensure that women receive the same benefits as with iron folic acid, while alleviating anaemia of inflammation.