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Polyhedron ◽  
2022 ◽  
pp. 115650
Author(s):  
Ana Maria Hodorogea ◽  
Anca Silvestru ◽  
Vito Lippolis ◽  
Alexandra Pop

2021 ◽  
Vol 8 ◽  
Author(s):  
Liang Chen ◽  
Ya Shen ◽  
Xiao Huang ◽  
Hua Li ◽  
Jian Li ◽  
...  

Aim: The purpose of this work was to develop and evaluate magnetic resonance imaging (MRI)-based radiomics for differentiation of orbital cavernous hemangioma (OCH) and orbital schwannoma (OSC).Methods: Fifty-eight patients (40 OCH and 18 OSC, confirmed pathohistologically) screened out from 216 consecutive patients who presented between 2015 and 2020 were divided into a training group (28 OCH and 12 OSC) and a validation group (12 OCH and 6 OSC). Radiomics features were extracted from T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI). T-tests, the least absolute shrinkage and selection operator (LASSO), and principal components analysis (PCA) were used to select features for use in the classification models. A logistic regression (LR) model, support vector machine (SVM) model, decision tree (DT) model, and random forest (RF) model were constructed to differentiate OCH from OSC. The models were evaluated according to their accuracy and the area under the receiver operator characteristic (ROC) curve (AUC).Results: Six features from T1WI, five features from T2WI, and eight features from combined T1WI and T2WI were finally selected for building the classification models. The models using T2WI features showed superior performance on the validation data than those using T1WI features, especially the LR model and SVM model, which showed accuracy of 93% (85–100%) and 92%, respectively, The SVM model showed high accuracy of 93% (91–96%) on the combined feature group with an AUC of 98% (97–99%). The DT and RF models did not perform as well as the SVM model.Conclusion: Radiomics analysis using an SVM model achieved an accuracy of 93% for distinguishing OCH and OSC, which may be helpful for clinical diagnosis.


Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1463
Author(s):  
Oleguer Parés-Badell ◽  
Xavier Martínez-Gómez ◽  
Laia Pinós ◽  
Blanca Borras-Bermejo ◽  
Sonia Uriona ◽  
...  

The aim of this study was to assess adverse reactions to COVID-19 vaccines, comparing the BNT162b2 or the mRNA-1273 COVID-19 vaccines and the presence and seriousness of a previous COVID-19 infection. We conducted a cross-sectional online survey of vaccinated healthcare workers at a tertiary hospital in Barcelona (Spain). Thirty-eight percent of vaccine recipients responded to the questionnaire. We compared the prevalence of adverse reactions by vaccine type and history of COVID-19 infections. A total of 2373 respondents had received the BNT162b2 vaccine, and 506 the mRNA-1273 vaccine. The prevalence of at least one adverse reaction with doses 1 and 2 was 41% and 70%, respectively, in the BNT162b2 group, and 60% and 92% in the mRNA-1273 group (p < 0.001). The BNT162b2 group reported less prevalence of all adverse reactions. Need for medical leave was significantly more frequent among the mRNA-1273 group (12% versus 4.6% p < 0.001). Interestingly, respondents with a history of allergies or chronic illnesses did not report more adverse reactions. The frequency of adverse reactions with dose 2 was 96% (95% CI 88–100%) for those with a history of COVID-19 related hospitalization, and 86% (95% CI 83–89%) for those with mild or moderate symptomatic COVID-19, significantly higher than for participants with no history of COVID-19 infections (67%, 95% CI 65–69%). Our results could help inform vaccine recipients of the probability of their having adverse reactions to COVID-19 vaccines.


BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Gao Keyu ◽  
Li Shuaishuai ◽  
Ashok Raj ◽  
Li Shuofeng ◽  
Liu Shuai ◽  
...  

Abstract Objective CT-Urography combined with 3D printing technology, digital design, construction of individualized PCNL puncture guides, and preliminary analyze their efficacy, safety puncture positioning for PCNL. Methods Twenty-two patients with renal calculi were randomly selected at the affiliated Hospital of Xuzhou Medical University during 2017–2018. We randomly divided the patients into two groups: in 10 experimental groups, we used our 3D printing personalized percutaneous puncture guide access plate for PCNL, and in the control group, 12 patients with standard USG guide PCNL. The accuracy of puncture position, puncture time, and intraoperative blood loss was compared. Results In the experimental group, 10 patients with 3D printing personalized percutaneous puncture guide access plate. The puncture needle was accessed through the guide plate and verified by the color Doppler. The single puncture, needle position, and depth success rate were 100.00% (10/10). The angles were consistent with the preoperative design. In the control group, 12 patients via USG guided PCNL success rate was 75.00% (9/12). The puncture time and amount of hemorrhage was (7.78 ± 0.94) min and (49.31 ± 6.43) mL, and (9.04 ± 1.09) min and (60.08 ± 12.18) mL, respectively. The above data of the two groups were statistically significant (P < 0.05). Conclusion 3D printing personalized percutaneous nephrolithotomy guide plate for PCNL can improve PCNL renal puncture channel positioning accuracy, shorten puncture time, reduce intraoperative blood loss, bleeding-related complications and provide a new method for PCNL renal puncture positioning, which is worthy of further clinical exploration.


Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2246
Author(s):  
Michael Mahler ◽  
Kishore Malyavantham ◽  
Andrea Seaman ◽  
Chelsea Bentow ◽  
Ariadna Anunciacion-Llunell ◽  
...  

(1) Background: Myositis specific antibodies (MSA) represent important diagnostic and stratification tools in idiopathic inflammatory myositis (IIM) patients. Here we aimed to evaluate the clinical performance of MSA profiled by a novel particle based multi-analyte technology (PMAT) in IIM and subsets thereof. (2) Methods: 264 IIM patients and 200 controls were tested for MSA using PMAT (Inova Diagnostics, research use only). Diagnostic performance was analyzed and composite scores were generated. (3) Results: The sensitivity/specificity of the individual MSA were: 19.7%/100% (Jo-1), 7.2%/100.0% (Mi-2), 3.0%/99.0% (NXP2), 3.8%/100.0% (SAE), 2.7%/100.0% (PL-7), 1.9%/99.5 (PL-12), 1.1%/100.0% (EJ), 15.5%/99.5% (TIF1ƴ), 8.3%/98.5% (MDA5), 6.1%/99.0% (HMGCR) and 1.9%/98.5% (SRP). Of all IIM patients, 180/264 tested positive for at least one of the MSAs. In the individual control group, 12/200 (6.0%) tested positive for at least one MSA, most of which had levels close to the cut-off (except one SRP and one PL-12). Only 6/264 (2.3%) IIM patients were positive for more than one antibody (MDA5/HMGCR, EJ/PL-7, 2 x MDA5/TIF1ƴ, EJ/SAE, SAE/TIF1ƴ). The overall sensitivity was 68.2% paired with a specificity of 94.0%, leading to an odds ratio of 33.8. The composite scores showed good discrimination between subgroups (e.g., anti-synthetase syndrome). (4) Conclusion: MSA, especially when combined in composite scores (here measured by PMAT), provide value in stratification of patients with IIM.


2021 ◽  
Vol 33 (3) ◽  
pp. 182
Author(s):  
Khairina Nasution ◽  
Deryne Anggia Paramita ◽  
Nova Zairina Lubis

Background: Atopic dermatitis (AD) is the most common skin disease in infants and children. AD is influenced by hereditary and environmental factors, and it is characterized by an inflammatory reaction in the skin. In developing countries, children suffering from AD are estimated around 10–20%, of which 60% of the cases persist into adulthood. Substance P is a cutaneous neuropeptide that contributes to the pathogenesis of AD. Substance P promotes the production of nerve growth factors from keratinocytes, and the release of histamine, leukotriene, or tumor necrosis factor from mast cells, which cause the growth of sensory nerve fibers, augmentation of skin inflammation, and are considered pruritogenic factors. Purpose: This study aims to determine the description of substance P in children with atopic dermatitis using a descriptive observational study with a cross-sectional approach. Methods: This is a destructive observational study with a crossectional approach samples were selected from AD patients at the Universitas Sumatera Utara Hospital. Result: The largest group of subjects were childhood (2–12 years old), there was 60%, followed by the adolescent group (12–18 years old) and the infant group (<2 years old). In the childhood group, the highest level of substance P was found in girls with a mean of 349.03 ± 146.7. On the other hand, the highest levels of substance P in the adolescent were found in males with a mean of 243.73 ± 64.57 ng/L. Conclusion: In this study, we found that the level of substance p was higher in the childhood group.


Author(s):  
Adisyah Fitrah Rahmadini ◽  
Desheila Andarini ◽  
Anita Camelia ◽  
Nurmalia Ermi ◽  
Mona Lestari

Introduction: One of the blacksmith industry centers in South Sumatra is in Limbang Jaya I, Ogan Ilir. Informal businesses such as blacksmiths are businesses that do not have operational standards in their work processes. Various risks from the work process can, therefore, arise, from injury to hearing loss. Therefore, it is necessary to carry out risk analysis in the work of blacksmith sector using Preliminary Hazard Analysis. Methods: This study used a descriptive research method with a qualitative approach through in-depth interviews, hazard checklists, and PHA worksheets. There were 12 informants in this study consisting of 4 key informants and 8 blacksmith worker informants. Results: The results showed that the hazards identified based on the work process were physical hazards, chemical hazards, ergonomic hazards, and psychosocial hazards. The efforts could be made by performing audiometric checks on workers, working time arrangements, stretching before and after work, and the use of Personal Protective Equipment (PPE). Conclusion: Based on the results of risk ranking, it is known that out of 34 lists of hazards that existed in the blacksmith's work process in Limbang Jaya 1 Village, there were 8 types of hazards included in the high risk group, 12 hazards included in the serious risk group, 12 hazards included in the medium risk group, and 2 hazards included in the low risk group.Keywords: blacksmith, preliminary hazard analysis, risk management


2021 ◽  
Author(s):  
◽  
Dylan Webb

<p>The variable β-diketiminate ligand poses as a suitable chemical environment to explore unknown reactivity and functionality of metal centres. Variants on the β-diketiminate ligand can provide appropriate steric and electronic stabilization to synthesize a range of β-diketiminate group 12 metal complexes. This project aimed to explore various β-diketiminate ligands as appropriate ancillary ligands to derivatise group 12 element complexes and investigate their reactivity.  A β-diketiminato-mercury(II) chloride, [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]HgCl, was synthesized by addition of [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]Li to mercury dichloride. Attempts to derivatise the β-diketiminato-mercury(II) chloride using salt metathesis reactions were unsuccessful with only β-diketiminate ligand degradation products being observed in the ¹H NMR.  A β-diketiminato-cadmium chloride, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]CdCl, was derivatized to a β-diketiminato-cadmium phosphanide, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]Cd P(C₆H₁₁)₂, via a lithium dicyclohexyl phosphanide and a novel β-diketiminato-cadmium hydride, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]CdH, via Super Hydride. Initial reactivity studies of the novel cadmium hydride with various carbodiimides yielded a β-diketiminato-homonuclear cadmium-cadmium dimer, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂Cd]₂, which formed via catalytic reduction of the cadmium hydride. Attempts to synthesize an amidinate insertion product via a salt metathesis reaction or a ligand exchange reaction proved unsuccessful but a novel cadmium amidinate, [{CH(N-C₆H₁₁)₂}₂{CH(N-C₆H₁₁)(N(H)-C₆H₁₁)}Cd], was synthesized from addition of dicyclohexyl formamidine to bis-hexamethyldisilazane cadmium.  A β-diketiminato-zinc(II) bromide, [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]ZnBr, was synthesized by addition of [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]Li to zinc dibromide. The β-diketiminato-zinc(II) bromide was derivatized to a variety of complexes (including amides and phosphanides) by a salt metathesis reaction. Chalcogen addition reactions were performed from [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}ZnP(C₆H₁₁)₂] to produce double addition products from sulfur, selenium and tellurium. Chalcogen addition reactions from [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}ZnP(C₆H₅)₂] produced a double addition product for selenium and a β-diketiminato-zinc(II) tellunoite bridged dimer, [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}Zn]Te, from tellurium. A total of 14 compounds were characterized via X-ray diffraction. Photoluminescence studies of the β-diketiminato-zinc(II) compounds were conducted where it was proposed that an electron transfer from the lone pair on the hetero-atom influenced the quantum yield and fluorescence intensities.</p>


2021 ◽  
Author(s):  
◽  
Dylan Webb

<p>The variable β-diketiminate ligand poses as a suitable chemical environment to explore unknown reactivity and functionality of metal centres. Variants on the β-diketiminate ligand can provide appropriate steric and electronic stabilization to synthesize a range of β-diketiminate group 12 metal complexes. This project aimed to explore various β-diketiminate ligands as appropriate ancillary ligands to derivatise group 12 element complexes and investigate their reactivity.  A β-diketiminato-mercury(II) chloride, [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]HgCl, was synthesized by addition of [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]Li to mercury dichloride. Attempts to derivatise the β-diketiminato-mercury(II) chloride using salt metathesis reactions were unsuccessful with only β-diketiminate ligand degradation products being observed in the ¹H NMR.  A β-diketiminato-cadmium chloride, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]CdCl, was derivatized to a β-diketiminato-cadmium phosphanide, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]Cd P(C₆H₁₁)₂, via a lithium dicyclohexyl phosphanide and a novel β-diketiminato-cadmium hydride, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂]CdH, via Super Hydride. Initial reactivity studies of the novel cadmium hydride with various carbodiimides yielded a β-diketiminato-homonuclear cadmium-cadmium dimer, [CH{(CH₃)CN-2,6-iPr₂C₆H₃}₂Cd]₂, which formed via catalytic reduction of the cadmium hydride. Attempts to synthesize an amidinate insertion product via a salt metathesis reaction or a ligand exchange reaction proved unsuccessful but a novel cadmium amidinate, [{CH(N-C₆H₁₁)₂}₂{CH(N-C₆H₁₁)(N(H)-C₆H₁₁)}Cd], was synthesized from addition of dicyclohexyl formamidine to bis-hexamethyldisilazane cadmium.  A β-diketiminato-zinc(II) bromide, [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]ZnBr, was synthesized by addition of [o-C₆H₄{C(CH₃)=N-2,6- iPr₂C₆H₃}{NH(2,6- iPr₂C₆H₃)}]Li to zinc dibromide. The β-diketiminato-zinc(II) bromide was derivatized to a variety of complexes (including amides and phosphanides) by a salt metathesis reaction. Chalcogen addition reactions were performed from [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}ZnP(C₆H₁₁)₂] to produce double addition products from sulfur, selenium and tellurium. Chalcogen addition reactions from [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}ZnP(C₆H₅)₂] produced a double addition product for selenium and a β-diketiminato-zinc(II) tellunoite bridged dimer, [o-C₆H₄{C(CH₃)=N-2,6-iPr₂C₆H₃}{NH(2,6-iPr₂C₆H₃)}Zn]Te, from tellurium. A total of 14 compounds were characterized via X-ray diffraction. Photoluminescence studies of the β-diketiminato-zinc(II) compounds were conducted where it was proposed that an electron transfer from the lone pair on the hetero-atom influenced the quantum yield and fluorescence intensities.</p>


2021 ◽  
Vol 22 (22) ◽  
pp. 12518
Author(s):  
Ji-In Ryu ◽  
Byoung-Eun Yang ◽  
Sang-Min Yi ◽  
Hyo-Geun Choi ◽  
Sung-Woon On ◽  
...  

This study aimed to evaluate the bone regeneration capacity of a customized alloplastic material and xenograft with recombinant human bone morphogenetic protein-2 (rhBMP-2). We prepared hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic bone blocks made using a 3D printing system and added rhBMP-2 to both materials. In eight beagle dogs, a total of 32 defects were created on the lower jaws. The defective sites of the negative control group were left untreated (N group; 8 defects), and those in the positive control group were filled with particle-type Bio-Oss (P group; 12 defects). The defect sites in the experimental group were filled with 3D-printed synthetic bone blocks (3D group; 12 defects). Radiographic and histological evaluations were performed after healing periods of 6 and 12 weeks and showed no significant difference in new bone formation and total bone between the P and 3D groups. The 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2. Through further study and development, the application of 3D-printed customized alloplastic grafts will be extended to various fields of bone regeneration.


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