transport function
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Author(s):  
Enrico Creaco ◽  
Feifei Zheng ◽  
Giuseppe Pezzinga

Abstract This paper presents a novel algorithm driven by the minimization of the transport function for the partitioning of water distribution networks (WDNs) into district metered areas (DMAs). The algorithm is based on the linear programming (LP) embedded inside a multi-objective genetic algorithm, which enables engineering criteria, such as the minimization of the boundary pipes and the maximization of the uniformity of DMAs, to be considered in the partitioning. Furthermore, the application of the algorithm on the dual network topology based on segments and valves guarantees that configurations of DMAs that respect the real positions of isolation valves for WDN partitioning are obtained. After being described on a small WDN, it is successfully validated on a large size WDN, proving better performance than other algorithms in the scientific literature for the generation of engineeringly appealing DMA configurations, with almost identical hydraulic performance to the unpartitioned WDN.


Author(s):  
S.M. Shakirova ◽  
◽  
D.M. Shakirova ◽  
◽  

As a result of the study, it was found that poisoning of rats with the herbicide 2,4 - DA for 4 weeks causes a decrease in the number of neurocytes in the celiac plexus, changes the protein synthesizing and energy systems of the cell, and accumulates residual structures in the form of lipofuscin. In the neuroplasm, the number of neurofilaments and neurotubules decreases, the organization of the myelin layer of fibers is disrupted. Changes affect the structure of the intima and media of blood vessels, leading to a violation of their transport function. When rats are treated with Taktivin, they show positive dynamics in the structure of the celiac plexus; the protein-synthesizing system is restored in the nuclei and neuroplasm of a number of cells. In the connective tissue stroma, the ultrastructure of collagen fibers improves, and the number of blood vessels increases.


Author(s):  
Jong Geol Lee ◽  
Globinna Kim ◽  
Seul Gi Park ◽  
Jung-Min Yon ◽  
Jeonghun Yeom ◽  
...  

Abstract The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid (FA) carriers in specific placental compartments were upregulated according to gestational age, and metabolomic analysis also showed that the placental transport of FAs increased in a time-dependent manner. Further analysis of two mutant mice models with embryonic lethality revealed that lipid-related signatures could reflect the functional state of the placenta. Our findings highlight the importance of the nutrient transport function of the primary placenta in the early gestational period and the role of lipids in embryonic development.


2021 ◽  
Author(s):  
Julia Quintana ◽  
María I. Bernal ◽  
Marleen Scholle ◽  
Heike Holländer‐Czytko ◽  
Nguyen T. Nga ◽  
...  
Keyword(s):  

Author(s):  
Mermanishvili Tatiana ◽  
Pataraia Giorgi ◽  
Chanturidze Nana

As a result of man’s technological activities, numerous quantities of lead and its compounds are spread into the environment annually. The long-term effects of low doses of lead on the lungs, heart muscle and the transport function of erythrocytes were investigated.  The study results indicate that long-term intake of small doses of lead, even in the absence of visible clinical manifestations, causes distinct structural changes and therefore, functional changes in the heart muscle, respiratory system, reduces the transport function of erythrocytes, and also possibly limiting the oxygen transport in myocytes and its deposition in tissues and diffusion into cells. There is no doubt that these changes will limit the ability to maximize the realization of physical activity.


2021 ◽  
Author(s):  
Yi-Chia Chung ◽  
Hao-Yu Cheng ◽  
Wei-Tung Wang ◽  
Yen-Jui Chang ◽  
Shih-Ming Lin

Abstract Glucosinolates (GLSs) are a group of secondary metabolites that are involved in the defense of herbivores. In Arabidopsis thaliana, Glucosinolate Transporter 1 (AtGTR1) transports GLSs with high affinity via a proton gradient-driven process. In addition to transporting GLSs, AtGTR1 also transports phytohormones, jasmonic acidisoleucine (JA-Ile), and gibberellin (GA). However, little is known about the mechanisms underlying the broad substrate specificity of AtGTR1. Here, we characterized the substrate preference of AtGTR1 by using a yeast uptake assay, and the results revealed that GLS transport rates are negatively correlated with the hydrophobicity of substrates. Interestingly, the AtGTR1 showed a higher substrate affinity for GLSs with higher hydrophobicity, suggesting a hydrophobic substrate binding pocket. In addition, a competition assay revealed that the presence of JA, salicylic acid (SA), and indole-3-acetic acid (IAA) inhibits the transport of GLSs in yeast, suggesting a potential regulatory mechanism of AtGTR1. To further characterize the functional properties of AtGTR1, mutagenesis experiments confirmed that the conserved EXXEK motif and Arg166 are essential for the GLS transport function. In addition, the purified AtGTR1 adopts a homodimeric conformation, which is possibly regulated by phosphorylation on Thr105. The phosphomimetic mutation, T105D, reduced its protein expression and completely abrogated its GLS transport function, indicating the essential role of phosphorylation on AtGTR1. In summary, this study investigated various factors associated with the GLS transport and increased our knowledge on the substrate preferences of AtGTR1. These findings contribute to understanding how the distribution of defense GLSs is regulated in plants and could be used to improve crop quality in agriculture.


Author(s):  
O. A. Koshelskaya ◽  
N. V. Naryzhnaya ◽  
I. V. Kologrivova ◽  
T. E. Suslova ◽  
O. A. Kharitonova ◽  
...  

The mechanisms of oxidative stress in adipocytes of local fat depots in patients with cardiometabolic diseases have been studied insufficiently.Purpose. To study the levels of reactive oxygen species (ROS) production in adipocytes of epicardial (EAT) and subcutaneous adipose tissue (SAT) in patients with stable coronary artery disease (CAD) and severe coronary atherosclerosis who underwent coronary artery bypass grafting; to investigate the potential relationships between the levels of ROS production by EAT and SAT adipocytes and obesity parameters, EAT accumulation, basal and postprandial glycemia, and blood lipid transport function.Material and Methods. The study included 19 patients (12 men and 7 women including 6 patients (31.5%) with type 2 diabetes mellitus) aged 53–72 years with stable CAD and severe coronary atherosclerosis. The material for the study was EAT and SAT adipocytes obtained by the enzymatic method from intraoperative explants. The ROS level in adipocytes was determined using the fluorimetry with 2,3-dihydrodichlorofluorescein diacetate. Anthropometric parameters of obesity and EAT thickness were studied using echocardiography. The blood lipid transport function and the levels of basal and postprandial glucose were assessed.Results. The levels of ROS production by EAT and SAT adipocytes in the overall group of patients did not differ significantly and amounted to 1710 (1608; 2079) and 1876 (1374; 2215) arbitrary units, respectively. The level of ROS production by SAT adipocytes did not correlate with the parameters of obesity, EAT thickness, or biomarker levels. The level of ROS production by EAT adipocytes directly correlated with the level of postprandial glycemia (rs = 0.62, p < 0.05), but did not correlate with measures of general and abdominal obesity, EAT thickness, and dyslipidemia. The level of ROS production by EAT adipocytes in patients with postprandial glycemia ≥ 7.7 mmol/L (n = 9) exceeded the corresponding value in patients with lower level of postprandial glycemia (n = 10): 2079 (1710; 2458) against 1625.5 (1332; 1699) arbitrary units (p = 0.015), respectively.Conclusion. We showed for the first time that the level of ROS production by EAT adipocytes in CAD patients with severe coronary atherosclerosis was directly associated with the level of postprandial glycemia. The highest level of ROS production in EAT adipocytes occurred in these patients when the level of postprandial glycemia exceeds 7.7 mmol/L.


Placenta ◽  
2021 ◽  
Vol 112 ◽  
pp. e20
Author(s):  
Katrien De Clercq ◽  
Jorge López-Tello ◽  
Yuki Katanosaka ◽  
Thomas Voets ◽  
Amanda N. Sferruzzi-Perri ◽  
...  

2021 ◽  
Vol 22 (17) ◽  
pp. 9440
Author(s):  
Chung-Pu Wu ◽  
Yan-Qing Li ◽  
Ya-Chen Chi ◽  
Yang-Hui Huang ◽  
Tai-Ho Hung ◽  
...  

Human ATP-binding cassette (ABC) subfamily G member 2 (ABCG2) mediates the transport of a wide variety of conventional cytotoxic anticancer drugs and molecular targeted agents. Consequently, the overexpression of ABCG2 in cancer cells is linked to the development of the multidrug resistance (MDR) phenotype. TP-3654 is an experimental second-generation inhibitor of PIM kinase that is currently under investigation in clinical trials to treat advanced solid tumors and myelofibrosis. In this study, we discovered that by attenuating the drug transport function of ABCG2, TP-3654 resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic ABCG2 substrate drugs topotecan, SN-38 and mitoxantrone. Moreover, our results indicate that ABCG2 does not mediate resistance to TP-3654 and may not play a major role in the induction of resistance to TP-3654 in cancer patients. Taken together, our findings reveal that TP-3654 is a selective, potent modulator of ABCG2 drug efflux function that may offer an additional combination therapy option for the treatment of multidrug-resistant cancers.


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