duration of untreated psychosis
Recently Published Documents


TOTAL DOCUMENTS

424
(FIVE YEARS 76)

H-INDEX

51
(FIVE YEARS 3)

2021 ◽  
Vol 29-30 ◽  
pp. 100084
Author(s):  
Joko Cahyo Baskoro ◽  
Ivana Ariella Nita Hadi ◽  
Maulidia Ekaputri ◽  
Noorhana Setiawati Winarsih

2021 ◽  
pp. 102823
Author(s):  
Rosana Shuhama ◽  
Victória Helena Stelzer Rocha ◽  
Camila Marcelino Loureiro ◽  
Fabiana Corsi-Zuelli ◽  
Jair Lício Ferreira Santos ◽  
...  

2021 ◽  
Vol 9 ◽  
Author(s):  
Naomi Takizawa ◽  
Ingrid Melle ◽  
Elizabeth Ann Barrett ◽  
Mari Nerhus ◽  
Akiah A. Ottesen

Background: Duration of untreated psychosis (DUP) is associated with outcome in psychotic disorders and influenced by contextual factors such as immigration. Here we aimed to investigate the effect of mental health literacy (MHL) on duration of untreated psychosis considering the influence of migration and education.Methods: A total of 269 participants who received their first adequate medical treatment for a psychotic disorder within the current or past year were included to the Thematically Organized Psychosis study in Oslo, Norway. Sociodemographic and clinical information was collected through systematic interviews. MHL was measured as “recognition of psychotic symptoms” and assessed by “The Attitudes and Beliefs about Mental Health Problems” schizophrenia version. Influence of education, migration and MHL on DUP was analyzed with hierarchical block-wise multiple regression analysis.Results: Recognition of psychotic symptoms explained a small but unique variance (2.3%) in DUP after the effects of other important predictors were controlled for. Longer DUP was also associated with less education, lower premorbid social, and academic functioning, a diagnosis within schizophrenia spectrum disorder, and earlier age of onset. The model explained 26% of variance in DUP. Migration after the age of six and length of education were associated with MHL but did not have a significant interaction with MHL in predicting DUP.Conclusions: MHL, measured as recognition of psychotic symptoms, has a small but significant independent effect on DUP. The effect of MHL was larger than years of education and migration history, and did not interact with either, in predicting DUP. This suggests that MHL is an independent factor in prevention strategies for early psychosis.


2021 ◽  
Vol 10 (1) ◽  
pp. 20
Author(s):  
Rina Krismiati Gani ◽  
Erikavitri Yulianti ◽  
Ifa Tunisya

Background: Schizophrenia is a chronic and serious clinical syndrome with very aggravating psychopathology involving perception, cognition, emotion, and behaviour. Currently, cognitive dysfunction is seen as a core disorder of schizophrenia. Duration of Untreated Psychosis (DUP) refers to the period from the onset of psychotic symptoms to the first adequate administration of antipsychotics.Aims: This review aims to analyse the impact of DUP on cognitive function in schizophrenia.Methods: PubMed and Google Scholar were searched using the following keyword: (cognitive function) and (neurodevelopmental OR neurotoxicity hypothesis) and (duration of untreated psychosis or DUP) and (schizophrenia or psychosis or psychotic) using the journal publication filter for the 2014-2020 issue. We also used textbooks published in the last 10 years and were related to writing themes.Review: There are two different opinions about the impact of DUP on the cognitive function of schizophrenic patients: (1) the neurodevelopmental hypothesis says there is no impact of the length of DUP on the cognitive function of schizophrenic patients; (2) the neurotoxicity hypothesis says the length of the DUP will impact the patient's cognitive function. Despite differences of opinion about the impact of DUP on cognitive function in schizophrenia, early intervention in schizophrenic patients is important because DUP is associated with worse general disease symptoms, lower likelihood of remission, more severe positive and negative symptoms, and worse social functioning and overall outcomes.Summary: There are differences of opinion about the impact of DUP on cognitive function in schizophrenic patients.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Meneca Becklén ◽  
Funda Orhan ◽  
Fredrik Piehl ◽  
Simon Cervenka ◽  
Carl M. Sellgren ◽  
...  

AbstractSchizophrenia is a severe mental disorder and one of its characteristics is cognitive impairments. Findings regarding levels of the heme metabolite and plasma antioxidant bilirubin in schizophrenia are inconclusive. However, a recently published study indicate that low levels of bilirubin may be implicated in the memory impairments seen in the disorder. The aim of this cross-sectional study was to investigate the levels of bilirubin in individuals with a first-episode psychosis (FEP) and to examine if bilirubin levels were associated to cognitive impairments, symptoms and duration of untreated psychosis (DUP). Bilirubin levels were reduced in 39 individuals with FEP compared with 20 HC (median [IQR]: 11.0 [9.0–13.0] µM vs. 15.0 [11.5–18.5] µM). In individuals with FEP, bilirubin levels were also positively correlated to two working memory tests (r = 0.40 and r = 0.32) and inversely correlated to DUP (r = − 0.36). Findings were not influenced by confounding factors. The results confirm the antioxidant deficit previously seen in schizophrenia, but also indicate that these changes may be related to DUP. The study also confirms that bilirubin may be implicated in the cognitive deficits that accompanies the disorder, here for the first time presented in individuals with FEP.


Author(s):  
Dearisa Yudhantara ◽  
◽  
Laksmi Muliawati ◽  
Zamroni Afif ◽  
◽  
...  

Mental health is a significant health problem in the world, including Indonesia. Lack of understanding and concern for the community, limitations and unequal distribution of mental health service provider also contribute to obstacles to increase public understanding and concern for mental health. This problem will give an impact on the difficulty of patients in accessing care and treatment. The emergence of the phenomenon of Duration of Untreated Psychosis (DUP) or untreated psychosis in society contributes to the worsening of the disease course of schizophrenic patients. One of the main clinical manifestations seen in schizophrenic patients is a decline in cognitive function. SCoRS is present as an easy and effective instrument in quantitatively measuring cognitive function. In the study used a modified SCoRS instrument that was more adapted to Indonesian’s culture. This study was conducted to determine the relationship between the duration of untreated psychosis and cognitive function using modified SCoRS, especially in schizophrenic patients at Saiful Anwar General Hospital. The research method used observational analytic with cross-sectional approach. Selection of research subjects based on inclusion and exclusion criteria. Then do the appropriate history taking and psychiatric examination. Correlation analysis using Spearman to determine the relationship of variable duration of psychosis without therapy and cognitive function assessed using SCoRS modification (p <0.05). The results prove that there is a significant relationship between the variable duration of therapy without therapy and cognitive function variables assessed using SCoRS modification with a weak correlation level (correlation coefficient 0.340).


Sign in / Sign up

Export Citation Format

Share Document