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Educatio ◽  
2022 ◽  
Vol 16 (2) ◽  
pp. 156-161
Author(s):  
Rudini Rudini ◽  
◽  
Hanofi Harianto ◽  
Ridwan Ridwan ◽  
Zulfa Azizaturrohmi ◽  
...  

The research aimed at finding out the use of a diary in improving the writing ability of the English students of Hamzanwadi University. The problems formulated in this research were (1) Is the use of diary effective in teaching writing for the English students of Hamzanwadi University? (2) How effective is using a diary in teaching writing for the English students of Hamzanwadi University? The research design of this study was one group pretest and posttest. The population of this research was the second-semester students of Hamzanwadi University, which consisted of 105 students in 4 classes. The present researcher took class D as the sample that consisted of 20 students. The present researcher generated a simple random sampling by obtaining an exhaustive list of a population and then randomly selecting a certain number of individuals to comprise the sample. A pretest and a posttest were given to the students to collect the data. The result of the data analysis indicated that the mean score of the pretest was 34.86 while in the posttest was 48.00. In testing the hypothesis, the result of the t-test was -9.706. The null hypothesis was rejected, and the alternative hypothesis was accepted. So, it can be said that using a diary was significantly effective in teaching writing.


Energies ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 8391
Author(s):  
Monika Hall ◽  
Achim Geissler

With the increasing use of renewable energy, the energy flexibility of buildings becomes increasingly important regarding grid support. Therefore, there is a need to describe this flexibility in a concise manner. For the characterization of building energy flexibility, flexibility factors can be used. The comparison of a selection of existing flexibility factors shows that they are not easy to use or understand for designers and users. A simplification is necessary. The aim of this study is to introduce a flexibility classification that is easy to understand and shows in an easy way if a building already uses the lowest energy cost level or if further improvement is possible. The classification expresses the annual energy costs in colored classes: green (class A) for lowest up to red (class D) for highest level. Basically, the flexibility classes can be derived for any metric of interest, in this paper examples are shown for energy costs and CO2eq emissions. The results given are based on the simulation of load management scenarios with different penalty signals applied for the heat pump operation of a residential building.


2021 ◽  
Author(s):  
◽  
John Z. Zhen

<p>This thesis details the development of a hand held mobile NMR system. The new system addressed the drawbacks on most of the existing NMR systems of being physically large and heavy with poor power inefficiency. In order to achieve the goal of producing a compact and power efficient NMR system, several high efficiency Class D RF amplifiers were developed which showed efficiencies of over 80%. The single cycle controlled PWM amplifier working at 2 MHz was a novel design and no other PWM Class D amplifiers has been reported to operate at high frequency with output power greater than 100 W. Development of the 20 MHz amplifier with 100 W constant amplitude output showed that the Class D amplifiers are suitable for NMR applications even at high frequency and further development of this amplifier to work at 17 MHz with amplitude modulation was successful. It paved the way for the development of a full mobile system with the newly available 17 MHz Mini-MOUSE sensor. The fully integrated mobile system was developed using SoC FPGA technologies. The use of a 400 Msps DDS device for RF pulse generation results in a broadband system. A duplexer was developed to enable sensor tuning and matching with the receiver amplifiers on the duplexer output stage provided 72 dB gain. The web based control program running on an iPad has shown great portability and it allows the system to be operated outdoors, even in remote areas. Experiments on industrial applications has shown successful T2eff measurements on polymer composites and rubber samples and showed the potential for such a system to be used in industrial applications. The fully integrated system prototype fits in a case measuring 140x120x100 mm (LxWxH) and weighs 800 grams and fulfil all the requirements for a mobile NMR system.</p>


2021 ◽  
Author(s):  
◽  
John Z. Zhen

<p>This thesis details the development of a hand held mobile NMR system. The new system addressed the drawbacks on most of the existing NMR systems of being physically large and heavy with poor power inefficiency. In order to achieve the goal of producing a compact and power efficient NMR system, several high efficiency Class D RF amplifiers were developed which showed efficiencies of over 80%. The single cycle controlled PWM amplifier working at 2 MHz was a novel design and no other PWM Class D amplifiers has been reported to operate at high frequency with output power greater than 100 W. Development of the 20 MHz amplifier with 100 W constant amplitude output showed that the Class D amplifiers are suitable for NMR applications even at high frequency and further development of this amplifier to work at 17 MHz with amplitude modulation was successful. It paved the way for the development of a full mobile system with the newly available 17 MHz Mini-MOUSE sensor. The fully integrated mobile system was developed using SoC FPGA technologies. The use of a 400 Msps DDS device for RF pulse generation results in a broadband system. A duplexer was developed to enable sensor tuning and matching with the receiver amplifiers on the duplexer output stage provided 72 dB gain. The web based control program running on an iPad has shown great portability and it allows the system to be operated outdoors, even in remote areas. Experiments on industrial applications has shown successful T2eff measurements on polymer composites and rubber samples and showed the potential for such a system to be used in industrial applications. The fully integrated system prototype fits in a case measuring 140x120x100 mm (LxWxH) and weighs 800 grams and fulfil all the requirements for a mobile NMR system.</p>


Author(s):  
Maghsoud Kafshnouchi ◽  
Marzieh Safari ◽  
Amir Khodavirdipour ◽  
Abbas Bahador ◽  
Seyed Hamid Hashemi ◽  
...  

Abstract Acinetobacter baumannii is a bacterium found in most places, especially in clinics and hospitals, and an important agent of nosocomial infections. The presence of class D enzymes such as OXA-type carbapenemases in A. baumannii is proven to have a key function in resistance to carbapenem. The aim of the current study is to determine the blaOXA-type carbapenemase genes and antimicrobial resistance among clinically isolated samples of A. baumannii. We assessed 100 clinically isolated specimens of A. baumannii from patients in intensive care units of educational hospitals of Hamadan, West of Iran. The A. baumannii isolates' susceptibility to antibiotics was performed employing disk diffusion method. Multiplex polymerase chain reaction was used to identify the blaOXA-24-like , blaOXA-23-like , blaOXA-58-like , and blaOXA-51-like genes. The blaOXA-23-like , blaOXA-24-like , and blaOXA-58-like genes' prevalence were found to be 84, 58, and 3%, respectively. The highest coexistence of the genes was for blaOXA-51/23 (84%) followed by blaOXA-51/24-like (58%). The blaOXA-51/23- like pattern of genes is a sort of dominant gene in resistance in A. baumannii from Hamadan hospitals. The highest resistance to piperacillin (83%) and ciprofloxacin (81%) has been observed in positive isolates of blaOXA-23-like . The A. baumannii isolates with blaOXA-58-like genes did not show much resistance to antibiotics. Based on the results of the phylogenetic tree analysis, all isolates have shown a high degree of similarity. This study showed the high frequency of OXA-type carbapenemase genes among A. baumannii isolates from Hamadan hospitals, Iran. Thus, applying an appropriate strategy to limit the spreading of these strains and also performing new treatment regimens are necessary.


Kardiologiia ◽  
2021 ◽  
Vol 61 (11) ◽  
pp. 57-64
Author(s):  
E. I. Tarlovskaya ◽  
Yu. V. Omarova

Aim      To study the consistency of the prescribed therapy with the EURO FORTA (2018) system in polymorbid patients with chronic heart failure (CHF) according to data of the local registry.Material and methods  The study included 313 patients with CHF aged 75±8.2 years. The Charlson Comorbidity Index (CCI) and the number of diseases (1–2, 3–5, >5) were calculated for all patients. Inpatient and outpatient treatment was assessed according to the EURO FORTA (2018) system based on polymorbidity degree, age, gender, and CHF type and severity.Results For the retrospective analysis of outpatient treatment, 5 groups of patients were isolated based on the drug class in the EURO FORTA system: group 1, patients treated only with class A drugs (3.51 %); group 2, class A and B drugs (22.36 %); group 3, class A, B, and C drugs (17.25 %); group 4, class A, B, C, and D drugs 10.86 % (А, В, С, D) and 16.31 % (А, В, D); and group 5, patients without an outpatient drug therapy (29.71 %). For the analysis of inpatient treatment, 4 groups of patients were isolated based on the drug class in the EURO FORTA system: group 1, patients treated only with class A drugs (0.32 %); group 2, class A and B drugs (15.97 %); group 3, class A, B, and C drugs (57.19 %); and group 4, separately analyzed patients treated with class C and D drugs or only D in combination with class A and B drugs. Thus, 28.11 % of patients at the outpatient stage and 82.75 % of patients at the inpatient stage received drugs with questionable efficacy/safety profiles (class C); 27.17 % of patients at the outpatient stage and 26.52 % at the inpatient stage received potentially inappropriate drugs (class D). At the outpatient stage in groups 2-4, most of patients (51.43–70.59 %) had >5 diseases (pmg=0.020). At the inpatient stage, there were no significant differences between groups in the number of diseases (pmg=0.349). The groups were comparable in the left ventricular ejection fraction depending on the CHF type (pmg=0.027 and pmg=0.778) at both stages of treatment. For instance, the same patient with preserved left ventricular ejection fraction could be included into EURO FORTA group 2 for the analysis of outpatient treatment while after prescription of the inpatient treatment, he/she could be included into group 3; pmg (intergroup, detecting differences for comparison of 3 groups) exceeded 0.017; therefore, the groups were comparable in the number of CHF patients with reduced, mid-range, and preserved left ventricular ejection fraction.Conclusion      Every second patient of the study had more than 5 diseases. Every third patient did not take any drugs at the outpatient stage. 28.11 % of patients received EURO FORTA class C drugs and 27.17% of patients received class D drugs at the outpatient stage. The drugs to be avoided in CHF, included primarily nonsteroid anti-inflammatory drugs (NSAIDs) and class I and III anti-arrhythmic medications (except for amiodarone). At the inpatient stage, 82.75 % of patients received EURO FORTA class C drugs and 26.52 % of patients received class D drugs. NSAIDs and ciprofloxacin prevailed among the drugs to be avoided in CHF.


2021 ◽  
Vol 25 (3 (99)) ◽  
pp. 38-41
Author(s):  
V. Zozulya

Aim of the study - to establish features of damage of the driver and the passenger in salon of the car of a class D at side collision. Material and methods. Cases of road accidents were analyzed from 2008 to 2021 in Zhytomyr, Rivne, Volyn regions of Ukraine. Side impact (right and left) with the fatal outcome of the driver and front passenger of class D cars were considered in the case of an automobile injury. We used general scientific and special methods, namely system-structural analysis, observation, comparison, description. Additionally, a forensic examination of the damage was carried out. Statistical analysis included primary data processing using descriptive statistics and testing the null hypothesis by multivariate analysis.Results. We identified characteristics of damage to the driver and passenger in a side impact. They were different and characterized by dependence on the right or left side of the collision.Conclusions. The resulting set of injuries witch characterize a driver or passenger of class D cars in left and right impact can be used to identify them in a forensic medical examination.


2021 ◽  
Author(s):  
Qiaoling Sun ◽  
Linlin Zhao ◽  
Liwen Tan

Abstract Objective: Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported in patients with schizophrenia. This study aimed to investigate the dynamics of EEG microstates in drug-naïve, first-episode schizophrenia (FE-SCH) and to test the relationship between EEG microstates and clinical symptoms.Methods: Resting-state EEG were recorded for 23 patients with FE-SCH and 23 healthy controls using a 64-channel cap. Three parameters, i.e., contribution, duration, and occurrence, of the four microstate classes were calculated. Group differences in EEG microstates and their clinical symptoms (assessed using the Positive and Negative Syndrome Scale) were analyzed.Results: Compared with healthy controls, patients with FE-SCH showed increased duration, occurrence and contribution of microstate class C and decreased contribution and occurrence of microstate class D. In addition, the score of positive symptoms in PANSS was negatively correlated with the occurrence of microstate D.Conclusions: Our findings showed abnormal patterns of EEG microstates in drug-naïve, first-episode schizophrenia, which might help distinguish individuals with schizophrenia in the early stage and develop early intervention strategies.


2021 ◽  
Vol 8 (Supplement_1) ◽  
pp. S721-S721
Author(s):  
Mark Estabrook ◽  
Krystyna Kazmierczak ◽  
Francis Arhin ◽  
Daniel F Sahm

Abstract Background Hypervirulent Klebsiella pneumoniae (hvKp), unlike classical K. pneumoniae (cKp), are often responsible for community-acquired infections in otherwise healthy individuals. The acquisition of hypervirulence genes by sequence type 11 (ST11) carbapenem-resistant (CR) Kp endemic in Asia is a grave threat. Aztreonam-avibactam (ATM-AVI) is a monobactam combined with a β-lactamase inhibitor for the treatment of infections caused by Enterobacterales isolates that carry Class A, B, C and some Class D β-lactamases. Methods 487 K. pneumoniae isolates were collected from 17 sites in China in 2019 as a part of the ATLAS global surveillance study. 220 isolates with MICs &gt;1 µg/ml to meropenem (MEM), ceftazidime or ATM were selected for whole genome sequencing (Illumina Hiseq 2x150 bp reads). Analyses were carried out using the CLC Genomics Workbench (Qiagen). Presence of the aerobactin synthesis locus differentiated hvKp and cKp. Antimicrobial susceptibility was determined by CLSI broth microdilution. Results Of the 487 isolates, MIC90 values for ATM-AVI (0.5 µg/ml; Table) were lower than those for any comparator tested, with only two isolates testing with MIC &gt;4 µg/ml. Of the isolates sequenced, 82/220 (37.3%) were ST11. 53/82 (64.6%) of these ST11 isolates were hvKp (ATM-AVI, MIC90 1 µg/ml; range, 0.25-4 µg/ml) and showed percentages of susceptibility &lt; 90% to three last-line agents (0% MEM-susceptible (S); 18.9% amikacin (AMK)-S; 88.7% tigecycline (TGC)-S). Isolates of other STs (Non-ST11) were less frequently identified as hvKp (24/138, 17.4%) and more Non-ST-11 hvKp and cKp alike were S to MEM and AMK relative to isolates of ST11 (75.0-86.8% MEM-S; 83.3-96.5% AMK-S). Likewise, the ATM-AVI MIC90 value (0.25 µg/ml) was 4-fold lower for Non-ST11 isolates. Results Table Conclusion CR ST11 hvKp represented at least 10.9% of the collected Kp isolates. ATM-AVI retained potent in vitro activity against these isolates which displayed resistance to a range of last-line agents. CST and TGC also displayed some activity but are limited in utility due to nephrotoxicity and poor accumulation in blood, respectively. The spread of virulence factors leading to the complicated clinical presentation of hvKp infection into multidrug-resistant lineages warrants continued surveillance. Disclosures Mark Estabrook, PhD, IHMA (Employee)Pfizer, Inc. (Independent Contractor) Krystyna Kazmierczak, PhD, IHMA (Employee)Pfizer, Inc. (Independent Contractor) Francis Arhin, PhD, Pfizer, Inc. (Employee) Daniel F. Sahm, PhD, IHMA (Employee)Pfizer, Inc. (Independent Contractor)


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