transition rates
Recently Published Documents


TOTAL DOCUMENTS

1354
(FIVE YEARS 236)

H-INDEX

55
(FIVE YEARS 5)

2022 ◽  
Vol 105 (1) ◽  
Author(s):  
Dominic M. Rouse ◽  
Erik M. Gauger ◽  
Brendon W. Lovett

2022 ◽  
Vol 2 ◽  
Author(s):  
Huan Chen ◽  
Guo-qing Gong ◽  
Mei Ding ◽  
Xiang Dong ◽  
Yuan-li Sun ◽  
...  

Purpose: Both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) are effective in reducing symptoms and medication scores and inducing long-term efficacy in patients with allergic rhinitis (AR). However, SLIT has been associated with poor patient adherence. This study investigates the factors impacting dropout rates from SLIT in house dust mite (HDM)-sensitized AR patients.Methods: A retrospective study was performed to analyze dropout rates and reasons in AR patients receiving Dermatophagoides farinae (Der f) SLIT with a follow-up period of 2 years.Results: A total of 719 HDM-sensitized AR patients received Der f-SLIT. Dropout rates increased with time and most occurred after 1 year of SLIT. By month 24, 654 (91%) patients had discontinued SLIT. The dropout rates by month 24 were 100, 90.1, and 91.1% in children <5 years old, children aged 5–18 years old, and adults ≥ 18 years old, respectively. Combination with allergic asthma and mono- or multi-sensitization to other aeroallergens did not affect the dropout rates. The most common self-reported reasons for dropouts were refusal of continuation, dissatisfaction with the efficacy, transition to SCIT, and adverse effects. Refusal of continuation increased with age, whereas transition to SCIT decreased with age. Ninety-seven cases transitioned from SLIT to SCIT, and the transition rates increased with time. Comorbid allergic asthma did not affect the transition rates. However, multi-sensitization was associated with a slightly higher rate of transition to SCIT. The most common reason for the transition was dissatisfaction with the efficacy (54.6%), which was only reported by patients older than 5 years. For children who began SLIT at younger than 5 years old, the most common reason (81.2%) for transition was age reaching 5 years.Conclusions: HDM-SLIT has a very high dropout rate, which is mainly due to refusal of continuation and dissatisfaction with the efficacy. Transitioning from SLIT to SCIT may help keep these patients on AIT and thus increase adherence and long-term efficacy.


Author(s):  
S. Haman Adama ◽  
D. Nga Ongodo ◽  
A. Zarma ◽  
J. M. Ema’a Ema’a ◽  
P. Ele Abiama ◽  
...  

In this work, Bohr Hamiltonian is used to explain the behavior of triaxial nuclei. A new potential, called Morse plus screened Kratzer potential, has been developed for the [Formula: see text]-part with [Formula: see text] fixed at [Formula: see text]. The Extended Nikiforov–Uvarov method involving Confluent Heun functions is used to derive the wave function and energy expression. The electric quadrupole transition rates and energy spectrum of platinum [Formula: see text] are determined and compared with the experimental data and some theoretical results.


2021 ◽  
Author(s):  
Navish Wadhwa ◽  
Alberto Sassi ◽  
Howard C. Berg ◽  
Yuhai Tu

Adaptation is a defining feature of living systems. The bacterial flagellar motor adapts to changes in external mechanical environment by adding or removing torque-generating stator units. However, the molecular mechanism for mechanosensitive motor remodeling remains unclear. Here, we induced stator disassembly using electrorotation, followed by the time-dependent assembly of the individual stator units into the motor. From these experiments, we extracted detailed statistics of the dwell times underlying the stochastic dynamics of stator unit binding and unbinding. The dwell time distribution contains multiple timescales, indicating the existence of multiple stator unit states. Based on these results, we propose a minimal model with four stator unit states – two bound states with different unbinding rates, a diffusive unbound state, and a recently described transiently detached state. Our minimal model quantitatively explains multiple features of the experimental data and allows us to determine the transition rates between all four states. Our experiments and modeling point towards an emergent picture for mechano-adaptive remodeling of the bacterial flagellar motor in which torque generated by bound stator units controls their effective unbinding rate by modulating the transition between the two bound states. Furthermore, the binding rate of stator units with the motor has a non-monotonic dependence on the number of bound units, likely due to two counter-acting effects of motor’s rotation on the binding process.


2021 ◽  
Vol 66 (12) ◽  
pp. 1013
Author(s):  
S.N. Abood ◽  
A.A. Al-Rawi ◽  
L.A. Najam ◽  
F.M. Al-Jomaily

Mixed-symmetry states of 92Zr and 94Mo isotopes are investigated with the use of the collective models, Interacting Boson Model-2 (IBM-2) and Quasiparticle Phonon Model (QPM). The energy spectra and electromagnetic transition rates for these isotopes are calculated. The results of IBM-2 and QPM are compared with available experimental data. We have obtained a satisfactory agreement, and IBM-2 gives a better description. In these isotopes, we observe a few states having a mixed symmetry such as 2+2, 2+3, 3+1, and 1+s. It is found that these isotopes have a vibrational shape corresponding to the U(5) symmetry.


2021 ◽  
Vol 46 ◽  
Author(s):  
Natalie Nitsche ◽  
Anna Matysiak ◽  
Jan Van Bavel ◽  
Daniele Vignoli

Recent research suggests that the fertility-education relationship may be mediated by the educational attainment of the partner, especially among the tertiary-educated. However, there are no studies focusing on the couple-education-fertility nexus among couples who achieved only basic educational attainment, even though resource pooling theory predicts differences in family formation by couples’ joint levels of socio-economic resources. We address this research gap and investigate how educational pairings among married and cohabiting partners relate to second and third birth transitions across 22 European countries, using data from the EU-SILC (European Union Statistics on Income and Living Conditions) panel and discrete time event history models. Our findings show significantly lower second and third birth transition rates among homogamous low-educated couples compared to heterogamous couples with one low- and one medium or highly-educated partner in the Nordic countries, but not across the rest of Europe. However, couples with one or two low-educated partners have significantly lower second birth rates compared with couples with two highly-educated partners in all European regions.


Author(s):  
Feng Hu ◽  
Yan Sun ◽  
Maofei Mei ◽  
Yuewu Pan ◽  
Hao Liu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document