The deceptive histomorphology of DGCT – A case report

Dentinogenic ghost cell tumors (DGCTs) are uncommon neoplasms classified as a solid variant of the calcifying odontogenic cyst and defined as a locally invasive neoplasm, characterized histologically by an ameloblastomatous epithelium with an area of ghost cell formation and a varying amount of dentinoid. Herein, we present the case of a 22-year old man who was referred to us due to recurrent swelling of right posterior mandibular region. The diagnosis of a DGCT was made by the use of advanced radiographic imaging and detailed histopathological examination.

The deceptive histomorphology of DGCT – A case report

Dentinogenic ghost cell tumors (DGCTs) are uncommon neoplasms classified as a solid variant of the calcifying odontogenic cyst and defined as a locally invasive neoplasm, characterized histologically by an ameloblastomatous epithelium with an area of ghost cell formation and a varying amount of dentinoid. Herein, we present the case of a 22-year old man who was referred to us due to recurrent swelling of right posterior mandibular region. The diagnosis of a DGCT was made by the use of advanced radiographic imaging and detailed histopathological examination.

A Case of Ectopic Odontogenic Ghost Cell Tumor: Histogenetic Features of a New Entity

Background: Odontogenic tumors arising from extra-alveolar sites are extremerly rare. Dentinogenic ghost cell tumor (DGCT) is an uncommon odontogenic neoplasm characterized by CTNNB1 mutation, ghost cell appearance, and dentinoid-like calcification. We present a case of an ectopic DGCT arising from a calcifying odontogenic cyst in the floor of the mouth. Case presentation: A 72-year-old man presented with a painless sublingual swelling. Imaging revealed a multi-lobulated, solid-cyst mass on the floor of the mouth. Cytology showed folded epithelial clusters composed of basaloid cells, keratinized material, and dentinoid matrix. Histology also revealed a multi-cystic, cribriform to solid nest. Immunohistochemically, CK19, CK5/6, bcl-2, and p63 were diffuse positive. CTNTTB1 mutation was detected, leading to the final diagnosis of an ectopic DGCT. There was no recurrence during a 6-month follow-up. Conclusion: This is the first report to comprehensively describe the clinicopathological features of an ectopic DGCT of odontogenic origin, developing similarly to that of a true odontogenic DGCT. Accurate diagnosis of this rare entity is necessary to avoid overtreatment.