polyphenolic compound
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Nutrients ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 210
Author(s):  
Ailén Alemán ◽  
Daniel Marín-Peñalver ◽  
Pilar Fernández de Palencia ◽  
María del Carmen Gómez-Guillén ◽  
Pilar Montero

A sea fennel (Crithmum maritimum) aqueous extract was prepared and loaded into soybean phosphatidylcholine liposomes. Both the free extract (FE), and the empty (L) and loaded (L-FE) liposomes were shown to be non-cytotoxic to THP-1 and Caco-2 cells. The anti-inflammatory effect was tested on THP-1 cells differentiated into macrophages. FE showed anti-inflammatory activity, revealed by the induced secretion of IL-10 cytokines in macrophages that were subsequently stimulated with LPS. Also, a decrease in TNF-α production by L was observed, evidencing that liposomes reduced the pro-inflammatory mediators’ secretion. The liposomes (L) showed protective anti-inflammatory activity and also were able to downregulate the inflammation. Furthermore, L-FE were also found to downregulate the inflammation response, as they were able to decrease TNF-α secretion in macrophages previously exposed to LPS. The simulated in vitro gastrointestinal digestion (GID) of FE diminished the chlorogenic acid content (the main polyphenolic compound of the extract) by 40%, while in L-FE, the amount of this phenolic compound increased with respect to the undigested liposomes. The amount of bioaccessible chlorogenic, however, was similar for FE and L-FE. The percentage of chlorogenic acid absorbed through a Caco-2 cell monolayer after 3 h of incubation, was significantly similar for the extract and the liposomes (~1.5%), without finding significant differences once the extract and liposomes were digested.


2022 ◽  
Author(s):  
Huawei Li ◽  
Xiaoling Chen ◽  
Zhiqing Huang ◽  
Daiwen Chen ◽  
Bing Yu ◽  
...  

Ellagic acid (EA) is a natural polyphenolic compound, which shows various effects, such as anti-inflammatory, antioxidant, and inhibition of platelet aggregation. In this study, we investigated the effect of EA...


Author(s):  
Priti B. Savant ◽  
Manjusha S. Kareppa ◽  
Akshata U. Shinde

A disorder in which endometrial tissues develop outer side the uterus or uterine cavity is called as endometriosis. It affects mainly females in their reproductive years, and is an oestrogen-dependent condition. Endometriosis a gynaecological disease or disorders, occurs in about 10% of female in reproductive age and in upto 50% of females with in-fertility. It is serious type of Hormonal disease or disorders in female which is caused due to hormonal imbalance these diseases totally change the quality of womens life. Decreased quality of life is the most significant predictor of direct health care and total costs so avoid this next step greater way to take care “Prevention is always better than cure”. Curcumin is a natural polyphenolic compound extracted from the spice, turmeric and has been reported to evidence anti-inflammatory (agent which reduce inflammation), antioxidant (the agent which reduce oxidation), and anti-proliferative properties via the modulation of multiple cellular. However, it remains to be determined whether effect of curcumin affects in the management of process of endometriosis. Turmeric contain especially its most active compound Curcumin have many scientifically proven health benefits, it’s a potent Anti-inflammatory and antioxidant and may also help improve symptoms of endometrosis.


Author(s):  
Hardeep Singh Tuli ◽  
Hiral Mistry ◽  
Ginpreet Kaur ◽  
Diwakar Aggarwal ◽  
Vivek Kumar Garg ◽  
...  

: Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side effects of existing allopathic treatment have also initiated intense research in the field of bioactive phytochemicals. Gallic acid, a natural polyphenolic compound, exists freely as well as in polymeric forms. The anti-cancer properties of gallic acid are indomitable by a variety of cellular pathways such as induction of programmed cell death, cell cycle apprehension, reticence of vasculature and tumor migration, and inflammation. Furthermore, gallic acid is found to show synergism with other existing chemotherapeutic drugs. Therefore, the antineoplastic role of gallic acid suggests its promising therapeutic candidature in the near future. The present review describes all these aspects of gallic acid at a single platform. In addition nanotechnology-mediated approaches are also discussed to enhance bioavailability and therapeutic efficacy.


Author(s):  
Hui Lin ◽  
Liping Meng ◽  
Zhenzhu Sun ◽  
Shiming Sun ◽  
Xingxiao Huang ◽  
...  

Background: Dietary polyphenols help to prevent cardiovascular diseases, and interactions between polyphenols and gut microbiota are known to exist. In this study, we speculated that gut microbiota-mediated metabolite regulation might contribute to the anticardiotoxic effects of yellow wine polyphenolic compound (YWPC) in doxorubicin (DOX)-treated rats. Methods: 16S-rDNA sequencing was performed to analyze the effects of YWPC on the gut microbiota in DOX-treated rats (n=6). Antibiotics were used to investigate the contribution of the altered microbiome to the role of YWPC (n=6). Plasma metabolomics were also analyzed by untargeted gas chromatography-mass spectrometry systems. Results: YWPC ameliorated DOX-mediated cardiotoxicity, as evidenced by increased cardiac and mitochondrial function and reduced levels of inflammation and myocardial apoptosis ( P <0.05 for all). The low abundance of Escherichia – Shigella , Dubosiella , and Allobaculum , along with enrichment of Muribaculaceae_unclassified , Ralstonia , and Rikenellaceae_RC9_gut_group in the gut, suggested that YWPC ameliorated DOX-induced microbial dysbiosis. YWPC also influenced the levels of metabolites altered by DOX, resulting in lower arachidonic acid and linoleic acid metabolism and higher tryptophan metabolite levels ( P <0.05 for all). Correlational studies indicated that YWPC alleviated DOX-induced inflammation and mitochondrial dysfunction by modulating the gut microbial community and its associated metabolites. Antibiotic treatment exacerbated cardiotoxicity in DOX-treated rats, and its effect on the gut microbiota partly abolished the anticardiotoxic effects of YWPC, suggesting that the microbiota is required for the cardioprotective role of YWPC. Conclusions: YWPC protected against DOX-induced cardiotoxicity in a gut microbiota–dependent manner. This supports the use of dietary polyphenols as a therapeutic approach for the treatment of cardiovascular diseases via microbiota regulation.


Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4036
Author(s):  
Laxman Singh ◽  
Shikha Sharma ◽  
Suowen Xu ◽  
Devesh Tewari ◽  
Jian Fang

Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties. Atherosclerosis is a comprehensive term for a series of degenerative and hyperplasic lesions such as thickening or sclerosis in large- and medium-sized arteries, causing decreased vascular-wall elasticity and lumen diameter. Atherosclerotic cerebro-cardiovascular disease has become a major concern for human health in recent years due to its clinical sequalae of strokes and heart attacks. Curcumin concoction treatment modulates several important signaling pathways related to cellular migration, proliferation, cholesterol homeostasis, inflammation, and gene transcription, among other relevant actions. Here, we provide an overview of curcumin in atherosclerosis prevention and disclose the underlying mechanisms of action of its anti-atherosclerotic effects.


2021 ◽  
Vol 1 (1) ◽  
pp. 023-034
Author(s):  
Mamadou Sawadogo ◽  
Mindiédiba Jean Bangou ◽  
Bernice Dakio ◽  
Armandine Lema ◽  
Hyacinthe M. Thiombiano ◽  
...  

Hepatitis are pathologies of various etiologies affecting millions persons and the management by modern medicines still faces many difficulties. Our study aimed to make a repertory of medicinal plants used in the treatment of hepatitis in the Urbans areas of Bobo-Dioulasso, Dédougou and Fada N'Gourma followed by the phytochemical quantification and antioxidant activity of the most cited ones. We conducted an ethnobotanical survey among traditional Heath practitioners in the three studied locations to achieve this objective. Methanolic extracts of the plant organs were obtained using an extractor apparatus. Polyphenolic compounds contents quantification was done by spectrophotometry using Follin-Ciocalteu reagent and aluminum trichloride. Antioxidant activity was evaluated by three methods (ABTS●+, DPPH●, FRAP) and the reading of optical densities was performed with the spectrophotometer. A total of, 101 traditional healers were interviewed and 52 species were inventoried as being used in hepatitis care in the three localities. Among the species regularly cited in the different localities were Carica papaya (8%) and Agelanthus dodoneifolius (13%), and these two species were selected for the further investigation. Among the parts of plants most used there are roots (45%). Phytochemical investigations of C. papaya and A. dodoneifolius revealed that the best polyphenolic compound content was obtained by the unripe seeds of C. papaya with respectively 14.06±0.68 mg EAG and 4.37±0.57 mg EQ for 100 mg of extract. A. dodoneifolius extract was given the best antioxidant activity on ABTS●+ radical inhibition method with 9279.19±416.37 µmol EAA/g. All these activities could partially justify the use of screened species in the traditional treatment of hepatitis.


Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3885
Author(s):  
Ayana Ieda ◽  
Maki Wada ◽  
Yuuki Moriyasu ◽  
Yuuko Okuno ◽  
Nobuhiro Zaima ◽  
...  

The effect of ellagic acid (EA), a naturally occurring polyphenolic compound, on the secretion of apolipoproteins from human hepatocytes, HepG2, was investigated. The levels of apoB and apoA-1 secreted in the cell culture medium were determined by sandwich ELISA. EA did not affect cell viability at the tested concentrations (up to 50 µM). EA suppressed the secretion of apoB and enhanced that of apoA-1 from HepG2 cells. However, cellular apoB levels were increased, suggesting that EA inhibited the trafficking of apoB during the process of secretion. In contrast, the increase in the cellular levels of apoA-1 was consistent with its secreted levels. These results indicate that EA inhibits the secretion of apoB from hepatocytes and increases the secretion of apoA-1. Both of these effects are beneficial for lipoprotein metabolism in the prevention of lifestyle-related diseases. The detailed mechanism underlying these effects of EA on lipoprotein metabolism should be elucidated in the future, but this naturally occurring polyphenolic compound might be antihyperlipidemic. Based on these results, EA is suggested as a candidate food-derived compound for the prevention of hyperlipidemia.


2021 ◽  
Vol 10 ◽  
pp. 2129
Author(s):  
Zahra Moradi ◽  
Tofigh Jalalifar ◽  
Sarvenaz Roshanisefat ◽  
Sheida Jamalnia ◽  
Elnaz Reihani ◽  
...  

Natural compounds can be used as a complementary or alternative medicine for many diseases, such as osteoporosis. Curcumin, a polyphenolic compound and the major active component of turmeric, is reported to play important roles in bone health and osteoporosis. By affecting proliferation, differentiation, lifespan, and activity of osteoblasts and osteoclasts, curcumin can directly modulate bone tissue hemostasis. Due to its insignificant side effects and several therapeutic properties, such as antioxidant, anticancer, antibacterial, antifungal, anti-inflammatory, and antirheumatic, it could be a potential therapeutic agent to prevent and treat osteoporosis. This review aimed to summarize the most important findings of in vitro, animal, and human studies in an effort to clarify the possible effects of curcumin on osteoporosis and to explain the exact molecular mechanism by which curcumin exerts its action.[GMJ.2021;10:e2129] DOI:10.31661/gmj.v10i0.2129 


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1222-1222
Author(s):  
Hyun Kyung Kim ◽  
Eun Young Kang ◽  
Gwang-woong Go

Abstract Objectives Rottlerin (mallotoxin) is a polyphenolic compound in Mallotus philippensis. The anti-tumor, anti-inflammation, and mitochondrial uncoupling regulation effects of rottlerin have been known. However, the anti-obesity effect was not reported yet. Thus, we hypothesized that rottlerin would suppress body fat accumulation in obesity-induced mice. Methods Five-week-old male C57BL/6 mice were fed a high-fat diet (HFD) (60% kcal from fat) ad libitum for 8 weeks. Mice were randomly assigned to five groups as follows: 1) normal diet (18% kcal from fat), 2) negative control (60% kcal from fat), 3) rottlerin 10 (HFD + rottlerin 10 mg/kg bw), 4) rottlerin 20 (HFD + 20 mg/kg bw), 5) positive control (HFD + metformin 150 mg/kg bw). Rottlerin was daily supplemented by oral gavage. Body weight and feed intake were measured each week. Results Body weight and weight gain were reduced in rottlerin 20 compared to the control (P &lt; 0.001). Body fat mass was also significantly decreased by rottlerin (P &lt; 0.05). Total feed intake and lean mass were similar among HFD groups. Furthermore, energy expenditure was dose-dependently facilitated by rottlerin. RNA-sequencing results supported these findings that rottlerin 20 up-regulated fatty acid beta-oxidation, heat generation, and brown cell differentiation in white-adipose tissues. Rottlerin promoted a catabolic pathway such as lipolysis, thermogenesis, and oxidation in white adipose tissues. Moreover, non-esterified fatty acid levels were decreased by rottlerin (P &lt; 0.05), and hepatic triglyceride contents tended to decline in rottlerin 20 without hepatotoxicity. Non-shivering thermogenesis enzymes, PRDM16 (P = 0.06) and UCP1 (P &lt; 0.01), were stimulated by rottlerin. Conclusions Rottlerin supplementation altered body adiposity accumulation via enhancing fat utilization, lipolysis, and thermogenesis in obese mice. We suggest that rottlerin is a potent nutraceutical for anti-obesity. Funding Sources This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT; MSIT).


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