Treatment of skin diseases with calcium salts

Rosentul (Med. Ob. Iizhn. Pov., 1924, No. 5) saw very good results from the use of calcium salts, in the form of intravenous injections of a 10% solution of calcium chloride, 10 cubic meters each. with. PA injection, with the latter being repeated daily, for a number of skin diseases, namely, for acute eczema, urticaria, herpes zoster, lichen chronicus Vidaln, pruritus vulvae, pruritus ani, dermatitis herpetiformis Dhringa, etc.

Adult-onset perianal Langerhans cell histiocytosis presenting as pruritus ani: a case report and review of the literature

Background Langerhans cells belong to the histiocytic system and give rise to two tumors: Langerhans cell histiocytosis and Langerhans cell sarcoma. Clinical aggressiveness and degree of atypia distinguish the two neoplasms. Langerhans cell histiocytosis can infiltrate a single or multiple organ systems and particularly affects bone, skin, and lymph nodes. Perianal cutaneous Langerhans cell histiocytosis is a rare condition in adults, with 15 cases reported in the literature. Case We present the case of a 50-year-old hispanic man who presented with a 9-month history of pruritus ani and a personal history of diabetes insipidus. Punch biopsy confirmed a lesion of Langerhans cells origin but could not exclude Langerhans cell sarcoma because of limited sample size. An additional biopsy was planned as well as a positron emission tomography scan to determine the extent of disease spread. While the patient failed to follow up for repeat biopsy, the positron emission tomography scan was performed and was negative for metastatic disease. A stable perianal lesion of Langerhans cell histiocytosis with benign clinical features in a 50-year-old male despite lack of treatment is extremely rare and has not been described in the literature so far. Here, we review the presentation and workup of patients with Langerhans cell histiocytosis, review the relevant literature, and discuss treatment planning. Conclusion Perianal Langerhans cell histiocytosis is rare, and there should be a high index of suspicion with chronic or new perianal lesions, especially in a patient with a history of diabetes insipidus. It is also important to consider the patient’s full clinical course when it is not possible to reach a definitive pathological diagnosis before management.

Pruriplastic Itch—A Novel Pathogenic Concept in Chronic Pruritus

The International Association for the Study of Pain (IASP) defined three descriptors for pain: nociceptive pain is “pain that arises from actual or threatened damage to non neural tissue and is due to the activation of nociceptors”; neuropathic pain is “pain caused by a lesion or disease of the somatosensory nervous system”; and nociplastic pain is “pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain.” Based on clinical and pathophysiological arguments, a similar definition of “pruriplastic pruritus” should be made. Pruriplastic pruritus would include psychogenic pruritus, as well as some cases of pruritus ani, vulvar pruritus, sensitive skin or other poorly understood cases of pruritus. This new descriptor of itch could serve as systematic screening for altered pruriceptive function in patients who suffer from chronic itch and it may also help in defining better tailored treatment by identifying patients who are likely to respond better to centrally rather than to peripherally targeted therapies.

PREVENTION AND MANAGEMENT OF GUDAGATA VIKARA (ANORECTAL DISORDERS)- AYURVEDIC PERSPECTIVE

Gudagata Vikara (Anorectal disorders) refers to ailments of the anus and/ or rectum. Gudagata Vikara includes; Arsha (Haemorrhoids), Bhagandara (Fistula in Ano), Parikartika (Fissure in Ano), Guda Kandu (Pruritus Ani), etc. These are some common disorders in human being. A study by Sharma et al. showed that Hemorrhoids (49%) and fistula-in-ano (27%) were commonest anorectal conditions, mostly affecting the age group 18-45 years. Apathya Ahara and Vihara leads to vitiation of Doshas causing Mandagni and vitiation of Apanavayu resulting in stagnation of Mala in Gudavali which leads to anorectal disorders. In present study a thorough and scientific review of Ahara (diet) and Vihara (lifestyle) has been carried out for the prevention and management of anorectal diseases. Materials and methods: Ayurvedic treaties, text books, Dissertation, Articles from PUBMED, SCOPUS, Google scholar, Mesh, Google search has been searched thoroughly related to the subject. Discussion: Gudagata Vikara, Anorectal Disorders, Ahara (Diet), Vihara (Lifestyle), Dinacharya, Ritucharya, Sadvritta has been discussed. Conclusions: Food articles mentioned in Ayurvedic text are effective in the management of Anorectal diseases. Lifestyle changes according to Dinacharya, Ritucharya and Sadavritta and following do’s and don’ts are effective in the management of Anorectal diseases