Median line-gram and its application in the fault diagnosis of rolling bearing

The level selection of frequency band division structure relies on previous information in most gram approaches that capture the optimal demodulation frequency band (ODFB). When an improper level is specified in these approaches, the fault characteristic information contained in the produced ODFB may be insufficient. This research proposes a unique approach termed median line-gram (MELgram) to tackle the level selection problem. To divide the frequency domain signal into a series of demodulation frequency bands, a spectrum median line segmentation model based on Akima interpolation is first created. The level and boundary of the segmentation model can be adaptively identified by this means. Second, the acquired frequency bands are quantized using the negative entropy index, and the ODFB is defined as the frequency band with the largest value. Third, the envelope spectrum is used to determine the ODFB characteristic frequency to pinpoint the bearing fault location. Finally, both simulation and experimental signal analysis are used to demonstrate the efficiency of the suggested method. Furthermore, the suggested method extracts more defect feature information from the ODFB than existing methods.

Constructing an Imaginary Wall in the Ocean: A Technical Cartography Study on the Delimitation of Maritime Boundaries in the Provinces of South Sumatra and Bangka Belitung Islands Based on GIS

Marine management areas in Indonesia can be claimed 12 nautical miles from the coastline by regional governments, according to Law 23 of 2014. However, in reality, there are many provinces whose distances to other provinces are fewer than 2 × 12 nautical miles, necessitating that they be delimited fairly and proportionally. The provinces of South Sumatra and Bangka Belitung Islands are such an example. The absence of clear boundaries drawn on the national map of Indonesia was the fundamental problem and focus of this study, owing to the need for delimitation of regional sea boundaries. The delimitation method used to obtain the median line was the equidistance principle using the basepoint to basepoint approach and baseline to baseline, within the consideration of the coastline proportion. Small islands are taken into account as a highly influencing factor and cause of the deviation from the pure median line. The median line results based on the basepoint to basepoint approach showed an area of the ocean as large as 7426.24:5973.41 km2, considering the coastline proportion. Meanwhile, with the baseline to baseline approach, resulting area was 7430.65:5956.13 km2 (South Sumatra:Bangka Belitung Islands). The equidistance principle is a comprehensive method for calculating the median line, as shown in this research.

MEDIAN LINE IMMETRITY AT CENTRIC OCCLUSSION IN FKG UNMAS DENPASAR

Introduction: Facial appearances especially teeth and face are some of the most important things in this era. The symmetry of the dental median line with the facial median line needs to be considered to create a balanced, harmonious, and attractive facial structure, especially when smiling. The position of the maxillary median line to the facial median line is an important factor in orthodontic diagnosis. This research aims to obtain the symmetry of the dental median line with the facial median line during centric occlusion in dentistry students of the Mahasaraswati University of Denpasar. Materials and Methods: The type of this research is descriptive with a cross-sectional approach that involved 57 participants. Results and Discussions: The results of this research are the percentage of the students whose dental median line with a facial median line is symmetrical (≤ 1 mm) was 77% that obtained 44 participants, while the percentage of students who had a dental median line with a facial median line is not symmetrical (> 1 mm) were 23 % that obtained 13 participants with a shift of median line 2 mm in 7 participants, 3 mm in 5 participants, and 5 mm in 1 participant. Conclusion: Based on the results it can be concluded that the dentistry students of the Mahasaraswati University of Denpasar whose dental median line with their facial median line were symmetrical is more dominant.

Two new Pseudoceros (Platyhelminthes: Polycladida: Pseudocerotidae) from Agatti Island, India and a species checklist from Indian waters

The Lakshadweep archipelago constitutes a major coral region of India but still lacks sufficient biodiversity data owing to its remoteness and a low number of faunal studies in the past. The present paper describes two new Pseudoceros species collected from Agatti Island, Lakshadweep, India. Pseudoceros bipurpurea sp. nov. and Pseudoceros galaxea sp. nov. are described based on external and internal characters, supported with histological studies and photographs. Pseudoceros bipurpurea sp. nov. is characterized by a cream background colour and an orange median line surrounded by dense patches of purple spots, which tend to disperse and broaden towards the posterior end. Pseudoceros galaxea sp. nov. displays a brown background colour with numerous white to cream dots covering almost the entire dorsal surface and a thin black margin. This study adds two new species to the polyclad fauna in Indian waters, raising the count to 68 species. An updated checklist of polyclads from Indian coast is also provided.

ANALISIS YURIDIS PENGELOLAAN BATAS WILAYAH LAUT DAN PESISIR BERDASARKAN UNDANG-UNDANG NOMOR 23 TAHUN 2014 TENTANG PEMERINTAHAN DAERAH

Indonesia is an archipelagic country with an area of the ocean covering almost two-thirds of the total area of the archipelago which has potential with coastal, oceanic, mineral, oil and natural gas resources, however the boundaries and management of marine and coastal areas are not yet optimal and evenly distributed, especially by the Government. Area. Law Number 23 of 2014 concerning Regional Government has stipulated that the maximum boundary for the provincial sea area is 12 nautical miles, while the limit for regency / municipal marine production is a maximum of 4 miles, if the boundary of the sea area between provinces does not reach the maximum limit, the limit will be divided by the distance equal to the principle of the median line. The division of authority in the management of maritime and coastal boundaries is felt by the regional and central governments. This research is aimed at analyzing the implications of the Regional Government Law on several laws and regulations on marine and fisheries and to find out the ideal division of authority in the management of maritime and coastal boundaries. This study uses a normative juridical methodology approach. This research aims to provide a more detailed explanation regarding policies that regulate aspects of the management of maritime and coastal boundaries as well as the implementation of central, regional and other vertical authorities for the welfare of people in the Sea and Coastal areas. The results of the study can be concluded that the implementation of regional government authority in managing the boundaries of coastal sea areas is the division of concurrent governmental affairs of choice and division of affairs in the marine sector between the Central Government, Provincial Regions and Regency / Cities, especially in the marine and fisheries sector. Keywords: authority, local government, coast. Abstrak Indonesia merupakan negara kepulauan dengan luas wilayah lautan meliputi hampir dua pertiga bagian dari seluruh luas wilayah Nusantara yang memiliki potensial dengan sumber daya pesisir, lautan, mineral, minyak dan gas bumi, namun batas dan pengelolaan wilayah laut dan pesisir belum optimal dan merata khususnya oleh Pemerintah Daerah. Undang-Undang Nomor 23 tahun 2014 tentang Pemerintahan Daerah telah menetapkan bahwa batas maksimal wilayah laut provinsi sejauh 12 mil laut, sedangkan batas bagi hasil kelautan kabupaten/kota maksimal sejauh 4 mil, apabila batas wilayah laut antar provinsi tidak mencapai batas maksimal, maka batas akan dibagi sama jarak dengan prinsip garis tengah (median line). Pembagian kewenangan dalam pengelolaan batas wilayah laut dan pesisir dirasakan oleh pemerintah daerah dan pemerintah pusat. Penelitian ini diarahkan untuk menganalisis implikasi Undang-Undang Pemerintahan Daerah terhadap beberapa peraturan perundang-undangan tentang kelautan dan perikanan serta mengetahui pembagian kewenangan ideal dalam pengelolaan batas wilayah laut dan pesisir. Penelitian ini menggunakan pendekatan metodologi yuridis normatif. Dalam penelitian ini bertujuan untuk memberikan penjelasan lebih terperinci mengenai kebijakan yang mengatur aspek pengelolaan batas wilayah laut dan pesisir serta pelaksanaan kewenangan pusat, daerah dan lembaga vertikal lainnya untuk mensejahterakan masyarakat di wilayah Laut dan Pesisir. Hasil penelitian dapat disimpulkan bahwa pelaksanaan kewenangan pemerintah daerah dalam pengelolaan batas wilayah laut pesisir merupakan pembagian urusan pemerintahan konkuren pilihan dan pembagian urusan bidang Kelautan antara Pemerintah Pusat, Daerah Provinsi dan Daerah Kabupaten/Kota terkhusus pada sektor kelautan dan perikanan.

Sequential Use of Carfilzomib and Pomalidomide in Relapsed Multiple Myeloma: A Multi-Institutional Report from the Canadian Myeloma Research Group (CMRG) Database

Introduction: The treatment of multiple myeloma (MM) has dramatically improved due to the availability of immunotherapies such as daratumumab (Dara). However, in Canada, myeloma treatments now account for up to 20% of some provincial drug budgets. As Dara may be effective for a prolonged period and is quickly moving into first-line therapy, the Canadian body which provides guidelines to the provincial ministries of health recommended in 2019 against open sequencing of drugs in relapsed MM. Specifically, patients who receive Dara are now only eligible for public funding for either carfilzomib (CAR) or pomalidomide (POM)--but not both-- for relapsed MM. Given the known heterogeneity of myeloma, data gaps regarding the optimal sequencing of the available agents and uncertainly regarding the impact of this new restriction on patient outcomes, we utilized our Canadian national myeloma database to assess the sequencing of these two agents. The goal of our study was to understand the efficacy of these two commonly used treatments in the relapsed setting: 1) POM- after CAR-based therapy and 2) CAR- after POM-based therapy. Methods: We performed a retrospective observational study using the Canadian Myeloma Research Group Database (CMRG-DB), analyzed up to 30/06/2020. The CMRG-DB (formerly Myeloma Canada Research Network Database/MCRN-DB) is a prospectively maintained disease-specific database with over 7000 patients enrolled from 14 academic sites across Canada and includes legacy data collected from 2007. All patients with MM who were treated for relapsed disease with approved regimens using POM after CAR, or CAR after POM were included. Our primary outcomes were overall response rates (ORR) in each respective cohort. Secondary outcomes were progression-free survival (PFS), overall survival (OS), and a landmark OS analysis from treatment initiation with the first of the two agents. Survival was estimated using Kaplan-Meier methods and compared between groups using log rank test. Results: A total of 121 patients were included: 49 treated with POM after CAR, and 72 with CAR after POM. In the POM after CAR group, the median line of treatment was 4th for POM and 3rd for CAR. In the CAR after POM group, the median line of treatment was 4th for POM and 5th for CAR. In 79/121 patients (65%), the two therapies were directly sequential, 40/49 (82%) for the POM after CAR group, and 38/72 (54%) in the CAR after POM group. Baseline characteristics and treatment details are shown in Table 1. The ORR was 51% for patients treated with POM after CAR, and 49% for patients treated with CAR after POM. The median PFS for POM after CAR was 4.93 months (95% CI, 2.76-7.07), and for CAR after POM was 5.36 months (95% CI, 3.75-6.94). The median OS for patients treated POM after CAR was 11.01 months (95% CI, 4.50-19.13), and for patients treated with CAR after POM the median OS was 10.98 months (95% CI, 8.98-19.17) (Figure 1). In a landmark analysis using the time of the treatment initiation with the first of the two agents, the median OS of patients treated with CAR after POM was 37.61 months (95% CI 26.66-46.52) and 25.32 months (95% CI 14.56-41.19) for patients treated with POM after CAR (p=0.1270) (Figure 2). Conclusion: In this real-world observational study we demonstrated that both CAR- and POM-based therapies were effective treatment options for patients with advanced relapsed MM as each produced responses in approximately 50% of patients with a median PFS of about 5 months and median OS of 11 months. These results are comparable to those noted in prospective clinical trials leading to the approval of these agents in this setting. Further, a landmark analysis showed that using both agents sequentially late in the disease course provided reasonable OS outcomes, regardless of the order in which they are sequenced. Finally, as the cost of MM therapy increases, the use of real-world data can help determine the impact of funding decisions on the outcome of patients treated in a publicly funded universal health care system such the one in Canada. Disclosures McCurdy: GSK: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Sanofi: Honoraria; Amgen: Consultancy, Honoraria. Venner:Janssen, BMS/Celgene, Sanofi, Takeda, Amgen: Honoraria; Celgene, Amgen: Research Funding. Louzada:Janssen: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Pfizer: Consultancy, Honoraria; Amgen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria. LeBlanc:Celgene: Research Funding; Celgene Canada; Janssen Inc.; Amgen Canada; Takeda Canada: Membership on an entity's Board of Directors or advisory committees. Sebag:Takeda: Honoraria; Celgene: Honoraria; Janssen: Honoraria, Research Funding; Amgen: Honoraria. Song:Celgene: Research Funding; Celgene, Janssen, Amgen, Takeda: Honoraria. Jimenez-Zepeda:Janssen, Celgene, Amgen, Takeda: Honoraria. Kotb:Takeda: Honoraria; Merck: Honoraria, Research Funding; Celgene: Honoraria; Janssen: Honoraria; Sanofi: Research Funding; Karyopharm: Current equity holder in publicly-traded company; Amgen: Honoraria. Mian:Sanofi: Consultancy; Takeda: Consultancy, Honoraria; Celgene: Consultancy; Janssen: Consultancy, Honoraria; Amgen: Consultancy, Honoraria. White:Amgen: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria. Stakiw:Roche: Research Funding; Lundbeck: Honoraria; BMS: Honoraria; Novartis: Honoraria; Amgen: Honoraria; Celgene: Honoraria; Janssen: Honoraria, Research Funding. Reece:Janssen, Bristol-Myers Squibb, Amgen, Takeda: Consultancy, Honoraria; Janssen, Bristol-Myers Squibb: Membership on an entity's Board of Directors or advisory committees; Merck: Honoraria, Research Funding; Otsuka: Research Funding.

The Centre

The Centre originated from the Liberals, led by Eleftherios Venizelos, who embarked on a project of Greece’s modernization in the early twentieth century and the interwar period. After 1945, parties of the Centre were pressed in between the resurgent royalist Right and the communist Left, but in the 1960s, under George Papandreou’s ‘Center Union’, took centre stage in Greek politics. Since the 1974 transition to democracy, the Centre supported Europeanism and social democracy, but was overshadowed by the Panhellenic Socialist Movement (PASOK). The new Centre of the twenty-first century emerged in the form of various, relatively small and short-lived parties, such as ‘To Potami’ (the River party). It was a progressive ‘bourgeois’ force, reminiscent of its liberal legacy, which aspired to relieve the Greek economy from statism and support Greece’s anchoring on the eurozone. Its political profile was constructed in opposition to SYRIZA, the radical Left party claiming to have inherited the once PASOK-dominated Centre-Left. Overall, the Centre is a political space in the making and consists of politicians who may attract the vote of segments of the middle classes earning incomes above the median line and possessing skills suitable for a globalized economy.

A new species of alien terrestrial planarian in Spain: Caenoplana decolorata

Terrestrial planarians found in a plant nursery in Spain in 2012 are described as a new species, Caenoplana decolorata. Dorsally they are mahogany brown with a cream median line. Ventrally they are pastel turquoise fading to brown laterally. Molecular data indicate that they are a member of the genus Caenoplana, but that they differ from other Caenoplana species found in Europe. One mature specimen has been partially sectioned, and the musculature and copulatory apparatus is described, confirming the generic placement but distinguishing the species from other members of the genus. It is probable that the species originates from Australia.

Description of Calcaridorylaimus heynsi n. sp. (Nematoda: Dorylaimidae) from Potchefstroom, South Africa

Summary Calcaridorylaimus heynsi n. sp. is the second species of the genus to be described by both morphological and molecular techniques. Morphologically, it can be distinguished from all known species of Calcaridorylaimus by a combination of the following characters: presence of advulval ornamentations, short body (0.90-1.33 mm), slightly anteriorly positioned vulva (V = 47.6 (45.8-49.8)), short odontostyle in females and males (13.1 (11.5-14.5) μm and 13.5 (12.0-18.0) μm, respectively), number of supplements (2 + 9-11), short spicules when measured along the median line (40.4 (38-42) μm) and pore-like vulval opening. It is closest to C. sirgeli, especially in the presence of advulval ornamentations and the pore-like vulva. Phylogenetic analysis based on partial D2-D3 segment of 28S rDNA sequences showed that C. heynsi n. sp. is in a well-supported sister relation with Mesodorylaimus sp. in a clade with C. cignatus and Mesodorylaimus spp. In the Bayesian tree, using partial sequences 18S rDNA, M. japonicus was the closest taxon to the new species.