paternal influence
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2022 ◽  
Vol 12 ◽  
Author(s):  
Sofia Diaz-Lundahl ◽  
Arvind Y.M. Sundaram ◽  
Per Gillund ◽  
Gregor Duncan Gilfillan ◽  
Ingrid Olsaker ◽  
...  

During the last decade, paternal effects on embryo development have been found to have greater importance than previously believed. In domestic cattle, embryo mortality is an issue of concern, causing huge economical losses for the dairy cattle industry. In attempts to reveal the paternal influence on embryo death, recent approaches have used transcriptome profiling of the embryo to find genes and pathways affected by different phenotypes in the bull. For practical and economic reasons, most such studies have used in vitro produced embryos. The aim of the present study was to investigate the differences in the global transcriptome of in vivo produced embryos, derived from sires with either high or low field fertility measured as the non-return rate (NRR) on day 56 after first AI of the inseminated cows. Superovulated heifers (n = 14) in the age span of 12–15 months were artificially inseminated with semen from either high fertility (n = 6) or low fertility (n = 6) bulls. On day seven after insemination, embryos were retrieved through uterine flushing. Embryos with first grade quality and IETS stage 5 (early blastocyst), 6 (blastocyst) or 7 (expanded blastocyst) were selected for further processing. In total, RNA extracted from 24 embryos was sequenced using Illumina sequencing, followed by differential expression analysis and gene set enrichment analysis. We found 62 genes differentially expressed between the two groups (adj.p-value<0.05), of which several genes and their linked pathways could explain the different developmental capacity. Transcripts highly expressed in the embryos from low fertility bulls were related to sterol metabolism and terpenoid backbone synthesis, while transcripts highly expressed in the high fertility embryos were linked to anti-apoptosis and the regulation of cytokine signaling. The leukocyte transendothelial migration and insulin signaling pathways were associated with enrichments in both groups. We also found some highly expressed transcripts in both groups which can be considered as new candidates in the regulation of embryo development. The present study is an important step in defining the paternal influence in embryonic development. Our results suggest that the sire’s genetic contribution affects several important processes linked to pre-and peri implantation regulation in the developing embryo.


2021 ◽  
pp. 104973152110228
Author(s):  
Vincent Guilamo-Ramos ◽  
Adam Benzekri ◽  
Marco Thimm-Kaiser ◽  
Margarita Rivera ◽  
Taleria R. Fuller ◽  
...  

Purpose: We explored mechanisms of paternal influence associated with adolescent male condom decision making and behavior within an integrated framework of social neurobiological and behavioral theories of condom use. Method: Self-administered surveys from Latino and Black adolescent males aged 15–19 years ( n = 191) and their fathers were obtained. Dyads were recruited using area sampling methodology. Analyses included multivariable logistic and ordinary least squares regression examining direct and indirect associations of adolescent decision-analytic and paternal influence factors with adolescent condomless sex in the past 3 months. Results: Notions of masculinity, low-risk perception, partner approval of, and self-efficacy for condomless sex were associated with engaging in unprotected sex. Adolescent males reported reduced odds of engaging in condomless sex when indicating greater levels of father–son communication, relationship satisfaction, and paternal monitoring. Conclusion: Father-based interventions grounded in integrated theoretical frameworks of behavioral decision making and neuroscience have the potential to promote condom use among adolescent males.


PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4405 ◽  
Author(s):  
Chang Xu ◽  
Minghui Quan ◽  
Hanbin Zhang ◽  
Chenglin Zhou ◽  
PeiJie Chen

Purpose This study examined the associations of physical activity levels between parents and their pre-school children based on gender and weekday/weekend. Method A total of 247 parent-preschool child triads from Shanghai, China were analyzed. The children had a mean age of 57.5 ± 5.2 months. Both sedentary behavior and physical activity were measured in all participants using an ActiGraph GT3X+ accelerometer over seven consecutive days from Monday through the following Sunday. A multivariate regression model was derived to identify significant relationships between parental and child physical activity according to gender and weekday/weekend. Results There was a significant correlation between mothers’ and girls’ moderate-to-vigorous physical activity (MVPA) and total physical activity (TPA) on weekdays. Fathers’ MPVA levels correlated significantly with those of boys and girls, with paternal influence appearing to be stronger than maternal influence. However, there was not a significant correlation between fathers’ and children’s TPA. TPA levels of both mothers and fathers correlated with those of girls, but not with those of boys. Parental sedentary levels on the weekend correlated significantly with girls’ levels, but not with boys’ levels. Children’s physical activity levels on weekends were influenced more by fathers’ activity levels than by mothers’, while the opposite was observed on weekdays. Conclusion Sedentary behavior and physical activity levels of parents can strongly influence those of their preschool children, with maternal influence stronger during the weekdays and paternal influence stronger on the weekends. Parents’ activity levels influence girls’ levels more strongly than they influence boys’ levels.


2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 538-539
Author(s):  
R. C. Vann ◽  
B. P. Littlejohn ◽  
C. R. Long ◽  
T. H. Welsh ◽  
R. D. Randel

2014 ◽  
Vol 29 (11) ◽  
pp. 2402-2412 ◽  
Author(s):  
L. Simon ◽  
K. Murphy ◽  
M.B. Shamsi ◽  
L. Liu ◽  
B. Emery ◽  
...  

2014 ◽  
Vol 275 (6) ◽  
pp. 640-651 ◽  
Author(s):  
S. Meisgen ◽  
T. Östberg ◽  
S. Salomonsson ◽  
B. Ding ◽  
H. Eliasson ◽  
...  

2013 ◽  
Vol 72 (Suppl 1) ◽  
pp. A56.1-A56
Author(s):  
Sabrina Görgen ◽  
Therese Östberg ◽  
Stina Salomonsson ◽  
Bo Ding ◽  
Håkan Eliasson ◽  
...  

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