micropapillary carcinoma
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2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Qianqian Shi ◽  
Kang Shao ◽  
Hongqin Jia ◽  
Boyang Cao ◽  
Weidong Li ◽  
...  

AbstractInvasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell clusters in multiple lymph node foci arise from a single subclone of the primary tumor. We find evidence that the monoclonal metastatic ancestor in primary IMPC shares high frequency copy-number loss of PRDM16 and IGSF9 and the copy number gain of ALDH2. Immunohistochemistry analysis further shows that low expression of IGSF9 and PRDM16 and high expression of ALDH2 are associated with lymph node metastasis and poor survival of patients with IMPC. We expect these genomic and evolutionary profiles to contribute to the accurate diagnosis of IMPC.


2021 ◽  
Author(s):  
Yuting Zhao ◽  
Shouyu Li ◽  
Lutong Yan ◽  
Zejian Yang ◽  
Na Chai ◽  
...  

Abstract Background: Due to the rarity of invasive micropapillary carcinoma (IMPC) of the breast, no randomized trial has investigated the prediction of overall survival (OS) for patients with IMPC after breast-conserving surgery (BCS). This study aimed to construct a nomogram for predicting OS in IMPC patients after BCS. Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, 481 eligible cases diagnosed with IMPC were collected. OS in IMPC patients after BCS were assessed through multivariable Cox analyses, Harrell’s concordance indexes (C-indexes), receiver operating characteristics (ROCs) curves, calibration curves, decision curve analyses (DCA), and survival analyses. Results: 336 patients were randomly assigned into training cohort and 145 cases in validation cohort. The multivariate Cox regression analyses revealed that age at diagnosis, American Joint Committee on Cancer (AJCC) stage, marital status, hormone receptor status and chemotherapy were significant prognostic factors for OS in conservatively operated IMPC patients. The nomogram had a good prediction performance with the C-indices 0.771 (95%CI, 0.712-0.830) and 0.715 (95%CI, 0.603-0.827) in training and validation cohorts, respectively, and good consistency between the predicted and observed probability, with calibration curves plotted and the slope was close to 1. Based on calculation of the model, participants in low-risk group had a better OS in comparison with those in high-risk group (P < 0.001). Conclusions: A nomogram was developed to predict individualized risk of OS for IMPC patients after BCS. By risk stratification, this model is expected to guide treatment decision making in improving long-term follow-up strategies for IMPC patients.


2021 ◽  
Vol 12 (12) ◽  
Author(s):  
Jianke Lv ◽  
Qianqian Shi ◽  
Yunwei Han ◽  
Weidong Li ◽  
Hanjiao Liu ◽  
...  

AbstractInvasive micropapillary carcinoma (IMPC) is a special histological subtype of breast cancer, featured with extremely high rates of lymphovascular invasion and lymph node metastasis. Based on a previous series of studies, our team proposed the hypothesis of “clustered metastasis of IMPC tumor cells”. However, the transcriptomics characteristics underlying its metastasis are unknown, especially in spatial transcriptomics (ST). In this paper, we perform ST sequencing on four freshly frozen IMPC samples. We draw the transcriptomic maps of IMPC for the first time and reveal its extensive heterogeneity, associated with metabolic reprogramming. We also find that IMPC subpopulations with abnormal metabolism are arranged in different spatial areas, and higher levels of lipid metabolism are observed in all IMPC hierarchical clusters. Moreover, we find that the stromal regions show varieties of gene expression programs, and this difference depends on their distance from IMPC regions. Furthermore, a total of seven IMPC hierarchical clusters of four samples share a common higher expression level of the SREBF1 gene. Immunohistochemistry results further show that high SREBF1 protein expression is associated with lymph node metastasis and poor survival in IMPC patients. Together, these findings provide a valuable resource for exploring the inter- and intra-tumoral heterogeneity of IMPC and identify a new marker, SREBF1, which may facilitate accurate diagnosis and treatment of this disease.


2021 ◽  
Vol 15 (3) ◽  
pp. 224-229
Author(s):  
Cristhian Rene Vargas Estrada ◽  
Bruna Fernanda Firmo ◽  
Marjury Cristina Maronezi ◽  
André de Mattos Faro ◽  
Daniele Belchior Vela ◽  
...  

Mammary neoplasms in female dogs present a high incidence. Several histological types are observed, among them, micropapillary carcinoma is considered one of the most aggressive because it is related to vascular invasion, metastases and low survival time. Aimed to describe a case of micropapillary breast carcinoma, with cutaneous metastasis, in a dog. A canine, female, 14 years old, 8kg, not defined breed, uncastrated, nulliparous, with pseudocyesis and no contraceptives administration history was attended at the Veterinary Reproduction and Obstetrics Service from "Governador Laudo Natel” Hospital, FCAV, UNESP, Jaboticabal, presenting a breast ulcerated nodule, with one month estimated evolution. After stabilization and preoperative exams, radical unilateral mastectomy and ipsilateral axillary and inguinal lymphadenectomy were performed. Histopathologic diagnosis revealed micropapillary carcinoma and free surgical margins from neoplasm, however, there were metastasis in both lymph nodes. The tutors did not adhere to antineoplastic chemotherapy. In 60th post-surgical day, there was inflammatory reaction in the surgical scar region, with small cutaneous ulceration, where the elastogram  revealed  rigidity and shear velocity of 7.84m/s. Skin biopsy revealed metastasis of micropapillary breast carcinoma. There was progression of ulcerations, compromising animal’s welfare and its physiological activities, when on the 110th post-surgical day, it was decided to euthanize the patient.  The correct diagnosis and knowledge of tumor biological behavior are importants points to choose the correct treatment. The adjuvant chemotherapy treatment can impact on average survival time and ARFI elastography is an accurate predictor of rapid and non-invasive diagnosis of micropapillary carcinoma recurrence.


2021 ◽  
Author(s):  
Yuyuan Chen ◽  
Caixian Yu ◽  
Yiyin Tang ◽  
Dedian Chen ◽  
Keying Zhu ◽  
...  

Abstract Background: Invasive micropapillary carcinoma (IMPC) is one of the rare subtypes of breast cancer. This study aimed to explore a novel predictive nomogram model for IMPC prognosis.Methods: A total of 1855 IMPC patients diagnosed after surgery between 2004 and 2014 were identified from the Surveillance, Epidemiology and End Results (SEER) database to build and validate nomograms. All the patients included were divided into a training group (n=1300) and a validation group (n=555). A nomogram was created based on univariate and multivariate Cox proportional hazards regression analysis. In addition, receiver operating characteristic (ROC) curves were used to demonstrate the accuracy of the prognostic model. Decision curve analysis (DCA) was performed to evaluate the safety of the model in the range of clinical applications, while calibration curves were used to validate the prediction consistency.Results: Cox regression analysis indicated that age ≥62 at diagnosis, negative ER status, and tumor stage were considered adverse independent factors for overall survival (OS), while patients who were married, white or of other races, received chemotherapy or radiotherapy, had a better postoperative prognosis. The nomogram accurately predicted OS with high internal and external validation consistency index (C index) (0.756 and 0.742, respectively). The areas under the ROC curve (AUCs) of the training group were 0.787, 0.774 and 0.764 for 3 years, 5 years and 10 years, respectively, while those of the validation group were 0.756, 0.766 and 0.762, respectively. The results of both DCA and calibration curves demonstrated the good performance of the model.Conclusion: A novel nomogram for IMPC of the breast patients after surgery was developed to estimate 3- and 5-OS based on independent risk factors. This model has good accuracy and consistency in predicting prognosis and has clinical application value.


2021 ◽  
Vol 6 (3) ◽  
pp. 234-241
Author(s):  
Nadir Adnan Hacım ◽  
Gülçin Ercan ◽  
Yiğit Ülgen ◽  
Talar Vartanoğlu Aktokmakyan ◽  
Merve Tokoçin ◽  
...  

Author(s):  
Kazumori Arai ◽  
Tomohiro Iwasaki ◽  
Hisato Ishimatsu ◽  
Chinatsu Tsuchiya ◽  
Aki Kubota ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Shujian Xu ◽  
Yong Han

The incidence of papillary thyroid microcarcinoma (PTMC) has exponentially increased in the past three decades. The 2014 World Cancer Report stated that, among the new cases of thyroid carcinoma, >50% are PTMC. The incidence of thyroid cancer was growing by 20.1% annually in China. Most of PTMC have low risk and excellent prognoses. It must be realized that the problem of overdiagnosis of thyroid cancer is quite serious. In this article, we summarized the phenomenon and the cause of “overdiagnosis” of PTMC, the progress of clinical management, and the countermeasures.


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