subject characteristics
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H-INDEX

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Author(s):  
Sharon Eve Sonenblum ◽  
Megan Measel ◽  
Stephen H. Sprigle ◽  
John Greenhalgh ◽  
John McKay Cathcart

Aim: The goals of this study were 1) to identify the relationship between adipose (subcutaneous and intramuscular) characteristics and pressure injury (PrI) history in wheelchair users and 2) to identify subject characteristics, including biomechanical risk, that are related to adipose characteristics.Materials and Methods: The buttocks of 43 full-time wheelchair users with and without a history of pelvic PrIs were scanned in a seated posture in a FONAR UPRIGHT® MRI. Intramuscular adipose (the relative difference in intensity between adipose and gluteus maximus) and the subcutaneous adipose characteristics (the relative difference in intensity between subcutaneous adipose under and surrounding the ischium) were compared to PrI history and subject characteristics.Results: Participants with a history of PrIs had different subcutaneous fat (subQF) characteristics than participants without a history of PrIs. Specifically, they had significantly darker adipose under the ischium than surrounding the ischium (subQF effect size = 0.21) than participants without a history of PrIs (subQF effect size = 0.58). On the other hand, only when individuals with complete fat infiltration (n = 7) were excluded did individuals with PrI history have more fat infiltration than those without a PrI history. The presence of spasms (μ intramuscular adipose, 95% CI with spasms 0.642 [0.430, 0.855], without spasms 0.168 [−0.116, 0.452], p = 0.01) and fewer years using a wheelchair were associated with leaner muscle (Pearson Corr = −0.442, p = 0.003).Conclusion: The results of the study suggest the hypothesis that changes in adipose tissue under the ischial tuberosity (presenting as darker SubQF) are associated with increased biomechanical risk for pressure injury. Further investigation of this hypothesis, and the role of intramuscular fat infiltration in PrI development, may help our understanding of PrI etiology. It may also lead to clinically useful diagnostic techniques that can identify changes in adipose and biomechanical risk to inform early preventative interventions.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yaofeng Han ◽  
Jihui Xue ◽  
Wei Pei ◽  
Ya Fang

Abstract Background The global burden of disability continues to increase. Understanding the hierarchical structure of activities of daily living (ADL) and the trajectories of disability of elderly individuals is pivotal to developing early interventions. Purpose To determine the hierarchical structure of the ability of Chinese elderly individuals to perform ADL and further describe the trajectories of disability prior to death. Methods Longitudinal item response theory model (LIRT) was constructed for 28,345 elderly participants in the Chinese Longitudinal Healthy Longevity Survey, in which ADL were measured using the Katz scale from 1998 to 2018, until the participants’ death. Two difficulty parameters (κ−partial and κ−total) were used in the LIRT defining the thresholds for hierarchical structure in ADL (κ−partial: no limitation to partial limitation, κ−total: partial limitation to totally limited). Disability values estimated from the LIRT were fitted to a mixed-effects model to examine the manner in which the trajectories of disability varied with different subject characteristics. Results The findings confirmed the earliest loss in the capability to perform ADL (bathing(κ-partial = − 1.396), toileting(κ-partial = − 0.904)) at the level of partial limitation, with an overlap of partial and totally limited (total bathing, partial dressing, partial transferring, total dressing, partial feeding, partial continence), and finally a total loss of capability for toileting, feeding, transferring, and continence (κ-total = 3.647). Disability trajectories varied with sex (β = 0.041, SE = 0.001), place of residence (β = 0.010, SE = 0.001), and marital status (β = 0.144, SE = 0.001). Females, individuals living in urban areas, and those who lived without a spouse had a poorer disability status. Conclusion The loss in the ability to perform ADL has a hierarchical structure. Subject characteristics affect trajectories of disability in the elderly Chinese population.


Author(s):  
Ateke Goshvarpour ◽  
◽  
Atefeh Goshvarpour ◽  
Ataollah Abbasi ◽  
◽  
...  

Introduction: The importance of individual differences in the problem of emotion recognition has been repeatedly stated in the studies. The major concentration of this study was the prediction of heart rate variability (HRV) changes due to affective stimuli from the subject characteristics. These features were age (A), gender (G), linguality (L), and sleep (S) information. In addition, the most potent combination of individual variables (like gender and age (GA) or age, linguality, and sleep (ALS)) in the estimation of emotional HRV was explored. Methods: To this end, HRV indices of 47 college students exposed to images with four emotional categories, including happy, sad, afraid, and relaxed were analyzed. Then, a novel predictive model was introduced based on the regression equation. Results: The results showed distinctive emotional situations provoke the importance of different individual variable combinations. Generally, the most satisfactory variable arrangement in the prediction of HRV changes due to affective provocations was LS, GL, GA, ALS, and GALS. However, considering each subject separately, these combinations were changed. Conclusion: In conclusion, the suggested simple model is effective in offering new insight into the emotion studies regarding subject characteristics and autonomic parameters.


2021 ◽  
Vol 10 (3) ◽  
pp. 641
Author(s):  
Rita Novia Elviana ◽  
Hosnan Hosnan ◽  
Suparno Suparno

Discipline is one of the keys to success. Discipline is not only owned by students;but all jobs also must own discipline to show that the values of obedience and order are in accordance with the applicable norms and rules. Teachers also play an importand role to overcome the lack of discipline among students since students spend a lot of time at school with teachers, especially class teachers. This study aimed to determine how teachers embedded discipline to grade IV students through learning activities. The method used in this study was descriptive qualitative method. The data were collected through interview, observation, and documentation techniques. The resukts of this study indicated that teachers of SDN Karawaci Baru 6 were able to embed the discipline character to grade IV students and knew how to achieve subject characteristics through learning activities. 


Author(s):  
Stijn Van Der Auwera ◽  
Lien Mathys ◽  
Bert De Smedt ◽  
Joke Torbeyns ◽  
Lieven Verschaffel

Abstract The current study examined upper elementary school children’s frequent, efficient and adaptive use of direct subtraction (DS) and subtraction by addition (SBA) when mentally solving multi-digit subtractions, replicating and expanding previous research by Torbeyns et al. (2018). First, children were offered subtractions in two choice conditions in which they had to indicate whether they would use DS or SBA to solve each item. In the choice-compute condition they were allowed to make actual calculations, in the choice-decide condition they were not allowed to do so. Thereafter, two no-choice conditions were offered (mandatory use of either DS or SBA). Results showed that children made frequent, efficient and adaptive use of the untrained SBA strategy. Furthermore, children were most adaptive for task and subject characteristics in the choice-compute condition. The current study confirms previous findings on SBA, and questions current classroom practices that focus heavily on the development of DS.


2021 ◽  
Author(s):  
JDM Verberk ◽  
MLA de Hoog ◽  
I Westerhof ◽  
S Van Goethem ◽  
C Lammens ◽  
...  

ABSTRACTBackgroundHousehold transmission studies are useful to obtain granular data on SARS-CoV-2 transmission dynamics and to gain insight into the main determinants. In this interim report we investigated secondary attack rates (SAR) by household and subject characteristics in the Netherlands and Belgium.MethodsHouseholds with a real-time reverse transcription polymerase chain reaction (RT-PCR) confirmed SARS-CoV-2 index case were enrolled <48 hours following report of the positive test result. Daily symptom follow-up, standardized nose-throat sampling at enrollment and at new-onset acute respiratory illness (ARI) and paired dried blood spots (DBS) were collected from each participant. Children 0-2 years of age were additionally requested to collect a stool sample 7 days after enrollment and at new-onset of ARI. Swabs and stool samples were tested by RT-PCR for virus detection and DBS by multiplex protein microarray for detection of SARS-CoV-2 antibodies. The SAR was calculated 1) per-household as the proportion of households with ≥1 secondary SARS-CoV-2 case and 2) per-person as the probability of infection in household members at risk. We explored differences in SARs by household and subject characteristics.ResultsThis analysis includes 117 households that completed follow-up between April-December 2020. Among 382 subjects, 74 secondary infections were detected, of which 13 (17.6%) were asymptomatic and 20 (27.0%) infections were detected by seroconversion only. Of cases detected by RT-PCR, 50 (67.6%) were found at enrollment. The household SAR was 44.4% (95%-CI: 35.4-53.9%) and was higher for index cases meeting the ARI case definition (52.3%; 95%-CI 41.4-62.9%) compared to mildly symptomatic (22.2%; 95%-CI: 9.4-42.7%) and asymptomatic index cases (0.0%; 95%-CI: 0.0-80.2%). The per-person SAR was 27.9% (95%-CI: 22.7-33.8%). Transmission was lowest from child to parent (9.1%; 95%-CI: 2.4-25.5%) and highest from parent to child (28.1%; 95%-CI: 19.7-38.4%) and in children 6-12 years (34.2%; 95%-CI: 20.1-51.4%). Among 141 subjects with RT-PCR confirmed SARS-CoV-2 infections, seroconversion was detected in 111 (78.7%).ConclusionWe found a high household SAR, with the large majority of transmissions detected early after identification of the index case. Our findings confirm differential SAR by symptom status of the index. In almost a quarter of RT-PCR positive cases, no antibodies were detected. Other factors influencing transmission will be further explored as more data accumulate.


2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 2564-2564
Author(s):  
Rimas Vincas Lukas ◽  
Sylvia Christine Kurz ◽  
John Yu ◽  
Joseph C. Landolfi ◽  
Ganesh Rao ◽  
...  

2564 Background: Interleukin-12 (IL-12) results in anti-tumor responses in preclinical models but requires tightly controlled production to achieve safety and elicit immune system activation to realize efficacy. A phase 1 “main study” (NCT02026271) enrolled subjects with Grade III or IV gliomas who at the time of resection received intratumoral administration of a replication-deficient adenovirus expressing IL-12 under control of a transcriptional switch (Ad-RTS-hIL-12, Ad) regulated by veledimex (V), referred to as “Controlled IL-12”. It was anticipated that dexamethasone (dex), a lymphocytotoxic corticosteroid used to control edema, might diminish response to immunotherapies. We report updated findings from a substudy of subjects who were dex-free during the 4 weeks prior to Ad administration. Methods: Multicenter, phase 1 substudy (NCT03679754) that assesses safety and tolerability of Controlled IL-12 by local injection (Day 0, time of resection) of Ad (2 x 1011 viral particles) + V (20 mg PO QD x15 doses, Days 0-14) in subjects that were bevacizumab naïve and not receiving dex 4 weeks prior to Ad. Results: 36 subjects were treated. Of the 36, a majority received low-dose corticosteroids (≤ 20 mg dex total during V) as compared with the main study (75% vs 40%). More subjects in the substudy as compared with the main study had multifocal vs. unifocal disease (39% vs 7%). The safety profile was similar for both. Adverse reactions were mild to moderate and were manageable and reversable upon withholding V. Activation of the switch in both the main study and substudy (V 20 mg; n = 51) resulted in increased mean peak values (Day 0-28) of serum IL-12 (25.8 vs. 20.4 pg/mL) and IFN-g (57.0 vs. 39.5 pg/mL). Initial median overall survival (mOS) (unifocal, ≤ 20 mg dex cumulative, n = 20) was 16.2 (8.9, 18.5) mons (mean follow-up 12.3 mons) (Neuro Oncol 2019; 21 [suppl_6]:vi5). mOS including the impact of dex and key subject characteristics from the two studies (n = 51) will be updated and tumor response data will be provided. Conclusions: Monotherapy with Controlled IL-12 resulted in sustained increase in serum recombinant IL-12 and downstream endogenous IFN-g. There is evidence of immune-mediated anti-tumor effects which is associated with increased mOS as compared with historical controls. Follow up will investigate the adverse impact of dex, as well as the effect of additional subject characteristics ( e.g., unifocal vs. multifocal disease) on mOS. Clinical trial information: NCT03679754 .


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