human chorionic gonadotropin
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2022 ◽  
Vol 22 (1) ◽  
pp. 100591
Juliana Nascimento Duarte Rodrigues ◽  
José Domingos Guimarães ◽  
Maria Emilia Franco Oliveira ◽  
Jenniffer Hauschildt Dias ◽  
Aline Matos Arrais ◽  

Animals ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 143
Marina Bottrel ◽  
Isabel Ortiz ◽  
Manuel Hidalgo ◽  
María Díaz-Jiménez ◽  
Blasa Pereira ◽  

Two prostanglandins (luprostiol, LUP, and dinoprost, DIN) and two ovulation-inducing agents (human Chorionic Gonadotropin, hCG, and deslorelin, DES) were evaluated for luteolysis and estrus induction, and for ovulation induction, respectively, in embryo donor jennies. Twenty-six fertile Andalusian jennies were used. In Experiment 1, jennies (n = 112 cycles) were randomly treated with either LUP or DIN after embryo flushing. In Experiment 2, donors (n = 84 cycles) were randomly treated with either hCG or DES to induce ovulation. No differences were found between prostaglandins for all variables studied (prostaglandin–ovulation interval (POI), interovulatory interval (IOI), embryo recovery rate (ERR), positive flushing rate (PFR) and embryo grade (EG)). The ovulation rate was similar for hCG and DES (60.9% vs. 78.7%). However, the interval to ovulation (ITO) was affected (62.61 ± 7.20 vs. 48.79 ± 2.69 h). None of the other variables studied (ERR, PFR and EG) were affected (p > 0.05), except for embryo quality (p = 0.009). In short, both prostaglandins evaluated are adequate to induce luteolysis and estrus. Both ovulation-inducing agents hastened ovulation, but DES seems to be more effective than hCG. Follicular diameter affected the interval from treatment to ovulation, and high uterine edema was related to low embryo quality.

Usiwoma O. Ataikiru ◽  
Emil R. Iacob ◽  
Ingrith Miron ◽  
Calin M. Popoiu ◽  
Eugen S. Boia

Abstract Objectives Malignant tumor is a top-ranking cause of pediatric (>1-year) mortality in America and Europe. Among pediatric tumors, germ cell tumors (GCT) and gonadal tumors rank fourth (6%) by the Surveillance, Epidemiology, and End Results (SEER) program ( Continuous research on tumor markers harnesses their full potential in tumor detection and management. We evaluated the effectiveness of beta-human chorionic gonadotropin (β-hCG) and Alpha-fetoprotein (AFP) in Romanian children with (para)gonadal tumors and cysts, determining their accuracy in detecting malignancy, tumor-type, stage, complications, prognosis, and treatment response. Methods A 10-year retrospective study of AFP and β-hCG in 134 children with cysts and (para)gonadal tumors aged one month to 17 years was performed. Results AFP/β-hCG was unelevated in patients with cysts and nonmalignant tumors. Forty-eight/86 patients (43 GCT and 5 non-GCT) with malignant tumors had elevated AFP/β-hCG, 3/48 patients had recurrences, and 25/48 had mixed-GCT (68% had elevated AFP + β-hCG). All 30 patients with Yolk sac tumors (YST) or their components had elevated AFP. Area under the curve, sensitivity and specificity for GCT were: AFP + β-hCG- 0.828, 67.2%, 100%; AFP- 0.813, 64.1%, 100%; and β-hCG- 0.664, 32.8%, 100%. Two patients whose AFP/β-hCG levels remained elevated died. Common mixed-GCT components were YST-80% and embryonal carcinoma-72%. Thirty of 34 metastasis cases were GCT, with 26/34 patients having elevated AFP/β-hCG. Conclusions AFP/β-hCG detects malignant GCT and can determine tumor-type. GCT patients with markedly elevated AFP + β-hCG had poor prognosis, especially if recurrence or metastasis was present. Recurrence is unrelated to elevated AFP/β-hCG. The tumor components and quantity present determine AFP/β-hCG values in mixed-GCT.

Medicine ◽  
2021 ◽  
Vol 100 (51) ◽  
pp. e28144
Yi Zhong ◽  
Xing Chen ◽  
Yan Huang ◽  
Yi Jiang ◽  
Ting Chen ◽  

Vladimir Bilim ◽  
Senji Hoshi

A 95-year-old man was diagnosed with left pelvis cancer which presented with rapid tumor growth, multiple metastases, and bilateral tender gynecomastia. Elevated serum human chorionic gonadotropin(hCG), prolactin, estradiol, and progesterone were detected. The patient’s condition rapidly deteriorated and he passed away.

Gursaran P. Talwar ◽  
Jagdish C. Gupta ◽  
Shilpi Purswani ◽  
Hemant K. Vyas ◽  
Kripa N. Nand ◽  

This article is a tribute and homage to Gerard Chaouat who invited me to contribute this article. My years in France have remained very memorable to me. Reviewed briefly is the vaccine that was made against human chorionic gonadotropin (hCG) to prevent unwanted pregnancy in sexually active women. It has now been developed as a genetically engineered recombinant vaccine and passed onto industry for its production under good manufacturing practices (GMP) conditions for confirmatory trials. The trials have received the approval of the Drugs Controller General of India. The trials have started but have been interrupted by the coronavirus disease 2019 (COVID-19) pandemic. This vaccine is likely to have another highly beneficial application in the treatment of cancers expressing ectopically hCG.

2021 ◽  
pp. 1-4
Leticia R. de Oliveira ◽  
Carlos A. Longui ◽  
Guilherme Guaragna-Filho ◽  
José L. da Costa ◽  
Rafael Lanaro ◽  

The human chorionic gonadotropin (hCG) stimulation test that evaluates gonadal steroidogenesis is crucial in the assessment of patients with 46,XY disorders of sex development (DSD). This study aimed to determine a testosterone (T) cutoff level that indicates an adequate testicular function using LC-MS/MS after stimulation with recombinant human chorionic gonadotropin (rhCG) in a single dose. Nineteen prepubertal children with 46,XY DSD and normal T secretion were evaluated. T and dihydrotestosterone (DHT) levels were measured by liquid chromatography technique with tandem mass spectrometry (LC-MS/MS) before and 7 days after rhCG application at 250 µg. We suggest 0.89 ng/mL as the cutoff point for T after rhCG stimulation analyzed by LC-MS/MS.

F&S Reports ◽  
2021 ◽  
Hayley Richardson ◽  
Charikleia Kalliora ◽  
Monica Mainigi ◽  
Christos Coutifaris ◽  
Mary D. Sammel ◽  

2021 ◽  
Vol 1 (3) ◽  
pp. 394-402
Risma Dwi Sura Retnoningtyas ◽  
Ratna Kumala Dewi

Kehamilan merupakan suatu proses yang fisiologis dan alamiah yang dimulai dari ovulasi, konsepsi, nidasi, berkembangnya embrio dalam uterus hingga masa aterm umumnya pada trimester pertama  ditandai dengan gejala mual dan muntah (emesis gravidarum). Mual  dan muntah  disebabkan oleh peningkatan hormon Human Chorionic Gonadotropin (HCG) serta dipengaruhi oleh usia. Usia yang berisiko tinggi dalam kehamilan adalah kurang dari 20 tahun dan diatas 35 tahun. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh hormon Human Chorionic Gonadhotropin (HCG) dan usia ibu hamil terhadap emesis gravidarum pada kehamilan trimester pertama. Metode yang digunakan dalam penelitian ini yaitu metode tinjauan kepustakaan atau literature review. Sasaran pada penelitian ini yaitu ibu hamil trimester pertama dengan gejala emesis gravidarum. Emesis gravidarum adalah gejala yang biasanya terjadi ketika kehamilan trimester pertama. Emesis gravidarum dipengaruhi oleh peningkatan kadar HCG dan usia ibu hamil. Berdasarkan hasil pembahasan dapat disimpulkan bahwa hormon Human Chorionic Gonadhotropin (HCG) berpengaruh terhadap emesis gravidarum pada kehamilan trimester pertama. Usia ibu hamil berpengaruh terhadap kejadian emesis gravidarum pada kehamilan trimester pertama.

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