Fuzzy Cluster Analysis and Prediction of Psychiatric Health Data Based on BPNN

PMH (psychiatry/mental health) is affected by many factors, among which there are numerous connections, so the prediction of PMH is a nonlinear problem. In this paper, BPNN (Back Propagation Neural Network) is applied to fuzzy clustering analysis and prediction of PMH data, and the rules and characteristics of PMH and behavioral characteristics of people with mental disorders are analyzed, and various internal relations among psychological test data are mined, thus providing scientific basis for establishing and perfecting early prevention and intervention of mental disorders in colleges and universities. Artificial neural network is a mathematical model of information processing, which is composed of synapses similar to the structure of brain neurons. The fuzzy clustering analysis and data prediction ability of optimized PMH data are obviously improved. Applying BPNN to the fuzzy clustering analysis and prediction of PMH data, analyzing the rules and characteristics of PMH and the behavioral characteristics of patients with mental disorders, can explore various internal relations among psychological test data, and provide scientific basis for establishing early prevention and intervention of mental disorders.

Brain morphometry points to emerging patterns of psychosis, depression, and anxiety vulnerability over a 2-year period in childhood

Background Gray matter morphometry studies have lent seminal insights into the etiology of mental illness. Existing research has primarily focused on adults and then, typically on a single disorder. Examining brain characteristics in late childhood, when the brain is preparing to undergo significant adolescent reorganization and various forms of serious psychopathology are just first emerging, may allow for a unique and highly important perspective of overlapping and unique pathogenesis. Methods A total of 8645 youth were recruited as part of the Adolescent Brain and Cognitive Development study. Magnetic resonance imaging scans were collected, and psychotic-like experiences (PLEs), depressive, and anxiety symptoms were assessed three times over a 2-year period. Cortical thickness, surface area, and subcortical volume were used to predict baseline symptomatology and symptom progression over time. Results Some features could possibly signal common vulnerability, predicting progression across forms of psychopathology (e.g. superior frontal and middle temporal regions). However, there was a specific predictive value for emerging PLEs (lateral occipital and precentral thickness), anxiety (parietal thickness/area and cingulate), and depression (e.g. parahippocampal and inferior temporal). Conclusion Findings indicate common and distinct patterns of vulnerability for varying forms of psychopathology are present during late childhood, before the adolescent reorganization, and have direct relevance for informing novel conceptual models along with early prevention and intervention efforts.

The association between entrapment and depression among migrant workers in China: a social rank theory based study

Background Migrant workers are a group susceptible for depression evolution due to occupational maladaptive triggers. The social rank theory illustrates the pathology process from defensive adaptation to depression, pointing out the early prevention of depression by discovering entrapment. This study aims to reveal the relationship between migrant workers’ entrapment and depressive symptoms. Methods A total of 1805 migrant workers in Shenzhen were recruited by stratified multi-stage sampling. Sample’s demographic, behavioral and psychosocial characteristics were described and analyzed to reveal the relationship between entrapment and depressive symptoms. The Receiver Operator Characteristic was performed to find the optimal cut-off point of Entrapment Scale for predicting depressive symptoms. Results In the binary logistic regression of sociodemographic variables, migrant workers who were married (univariate odds ratio (ORu) = 0.69, 95% Confidence Interval (CI) = 0.56–0.84), owned 1 or 2 children (ORu = 0.71, 95% CI = 0.58–0.86), had been working over 10 years (ORu = 0.71, 95% CI = 0.54–0.95), earned > 4999 yuan per month (ORu = 0.68, 95% CI = 0.47–0.99; multivariate odds ratio (ORm) = 0.57, 95% CI = 0.38–0.87) or with low risks of alcohol use disorders (ORu = 0.51, 95% CI = 0.34–0.75) had lower risks of depressive symptoms. After adjusted the aforementioned significant sociodemographic variables, migrant workers with severer entrapment were more likely to have depressive symptoms (adjusted odds ratio (ORa) = 1.13, 95% CI = 1.12–1.15). Besides, the study proved the reliability and validity of the Chinese version Entrapment Scale, preferring a two-dimensional structure, and 11 was the optimal cut-off value of this scale for predicting depressive symptoms among migrant workers. Conclusions This result indicates the potential value of entrapment according to the social rank theory on facilitating early prevention of migrant works’ depression and the application value of Entrapment Scale for effectively measuring mental status among migrant workers.

The role of nutrients and probiotics in treatment of depression

Currently, a growing amount of data is emerging on the role of various environmental factors (nutrients, gut microbiota, etc.) on formation of depression. The impact on these factors can be effective not only in treatment of major depressive disorder, but also in its early prevention. Therefore, a more detailed study of environmental factors in depression can lead both to a better understanding of the etiology and pathogenesis of the disorder and to optimization of approaches to its treatment. The aim of the review was to assess the potential role of a number of environmental factors associated with nutritional aspects and characteristics of individual microflora, as well as to review the prospects of a strategy for affecting these factors in treatment and prevention of depression.

Preeclampsia and pathology of placentation

Etiology of pre-eclampsiaremainsunclear. However, it is recognized that genetic factors of both mothers and fathers sides can determine the development of this awesome complication of pregnancy. The interplay of genetic factors with external influences determines the risk level of pre-eclampsia. Today it is reasonable to assert that pre-eclampsia is a complication of pregnancy associated with the disturbances of the process of trophoblast invasion and changes in haemodynamics in spiral arteries. The process of trophoblast invasion proved to be coordinated by combined interaction of cytokines, factors of adhesion and different growth factors.Functional abnormalities of endothelium of placental and pre-placental vessels may be a result but not a cause of development ofpre-eclampsia, pathophysiology of which is studied still insufficiently. However, the disturbance оf NO, endothelein release and thrombocytes homeostasis as well are certain to be the main manifestations of this pregnancy complication. A fter revealing all the mechanisms of process of trophoblast invasion disturbances an actual possibility of early prevention and treatment of pre-eclampsia may be elaborated.

Epidemiological evidence relating risk factors to chronic obstructive pulmonary disease in China: A systematic review and meta-analysis

Background Chronic obstructive pulmonary disease (COPD), the most common chronic respiratory disease worldwide, not only leads to the decline of pulmonary function and quality of life consecutively, but also has become a major economic burden on individuals, families, and society in China. The purpose of this meta-analysis was to explore the risk factors for developing COPD in the Chinese population that resides in China and to provide a theoretical basis for the early prevention of COPD. Methods A total of 2457 cross-sectional, case-control, and cohort studies published related to risk factors for COPD in China were searched. Based on the inclusion and exclusion criteria, 20 articles were selected. Stata 11.0 was used for meta-analysis. After merging the data, the pooled effect and 95% confidence intervals (CIs) were calculated to assess the association between risk factors and COPD. Heterogeneity between studies was assessed using I2 and Cochran’s Q tests. Begg’s test was used to assess publication bias. Results Exposure to particulate matter less than 2.5 μm in diameter (PM2.5) (pooled effect = 1.73; 95%CI: 1.16~2.58; P <0.01), smoking history (pooled effect = 2.58; 95%CI: 2.00~3.32; P <0.01), passive smoking history (pooled effect = 1.39; 95%CI: 1.03~1.87; P = 0.03), male sex(pooled effect = 1.70; 95%CI: 1.31~2.22; P <0.01), body mass index (BMI) <18.5 kg/m2 (pooled effect = 1.73; 95%CI: 1.32~2.25; P <0.01), exposure to biomass burning emissions (pooled effect = 1.65; 95%CI: 1.32~2.06; P <0.01), childhood respiratory infections (pooled effect = 3.44; 95%CI: 1.33~8.90; P = 0.01), residence (pooled effect = 1.24; 95%CI: 1.09~1.42; P <0.01), and a family history of respiratory diseases (pooled effect = 2.04; 95%CI: 1.53~2.71; P <0.01) were risk factors for COPD in the Chinese population. Conclusion Early prevention of COPD could be accomplished by quitting smoking, reducing exposure to air pollutants and biomass burning emissions, maintaining body mass index between 18.5 kg/m2 and 28 kg/m2, protecting children from respiratory infections, adopting active treatments to children with respiratory diseases, and conducting regular screening for those with family history of respiratory diseases.

Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes

Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D will result in chronic high blood sugar levels, eventually resulting in T2D complications. These complications, such as kidney, eye, and nerve damage, are even harder to treat. Identifying individuals at high risk of developing T2D and its complications is essential for early prevention and treatment. Numerous studies have been done to identify biomarkers for T2D diagnosis and prognosis. This review focuses on recent T2D biomarker studies based on circulating nucleic acids using different omics technologies: genomics, transcriptomics, and epigenomics. Omics studies have profiled biomarker candidates from blood, urine, and other non-invasive samples. Despite methodological differences, several candidate biomarkers were reported for the risk and diagnosis of T2D, the prognosis of T2D complications, and pharmacodynamics of T2D treatments. Future studies should be done to validate the findings in larger samples and blood-based biomarkers in non-invasive samples to support the realization of precision medicine for T2D.

Literature Review : Hubungan Tingkat Kontrol Asma Dengan Kualitas Hidup Penderita Asma

Knowledge is the result of knowing someone by sensing certain objects, sensing can occur through the five human sense, namely the senses of sight, hearing, smell, taste, and touch. Good knowledge can couse good preventive behaviors. Early prevention is the only thing that can be done to avoid the recurrebce of asthma. The prevention is done to minimize the risk of asthma attacks. This literature review aimed to determine the correlation between knowledge about asthma and the prevention of recurrence of asthma. This literature Review accessed PUBMED by combining the keywords “Knowledge” and “Prevention Asthma”. Participants in this study were patients with asthma who had a P-Value of 0,000. The Results showed that there was a correlation between knowledge about asthma and efforts to prevent the recurrence of asthma. This study is expected to be a reference for hospitals or health centers to increase educational activities and knowledge about asthma.Keyword: Asthma Knowledge, Asthma Prevention AbstrakTingkat kontrol asma merupakan suatu tingkatan pengamatan manifestasi asma pada penderita asma atau berkurangnya maupun menghilangnya penyakit asma melalui pengobatan. Tingkat kontrol asma terbagi atas terkontrol penuh, terkontrol sebagian, dan tidak terkontrol. Pengklasifikasian tersebut memudahkan dalam mengetahui derajat berat dan ringannya penyakit asma serta untuk mengetahui respon terapi. Penyakit asma memberikan dampak negatif terhadap kualitas hidup penderita asma. Dampak negatif yang ditimbulkan antara lain terganggunya aktivitas sehari-hari, tidak dapat mengikuti pelajaran sekolah, tidak kuat untuk melakukan kegiatan olahraga, dan hilangnya hari kerja bagi penderita asma yang bekerja di kantor. Kontrol asma berhubungan dengan kualitas hidup. Semakin buruk kontrol asma, maka kualitas hidup akan semakin menurun. Literature Riview ini bertujuan untuk Mengetahui hubungan tingkat kontrol asma dengan kualitas hidup pasien asma. Literature review dilakukan dengan menggunakan artikel yang bersumber dari database online yaitu PubMed, Garuda dan Google Scholar dengan kata kunci “Asthma AND Asthma control level”, “Quality of life”, “Tingkat kontrol asma”, dan “Kualitas hidup” dengan batasan 5 tahun terakhir. Hasil penelitian ini menunjukan bahwa ada hubungan tingkat kontrol asma dengan kualitas hidup penderita asma. Tingkat kontrol asma salah satu faktor yang mempengaruhi kualitas hidup pasien asma.Kata Kunci: Asma, Tingkat kontrol asma, Kualitas hidup.