Background: The study of the zootechnical performance of Tilapia cabrae and Oreochromis schwebischi was carried out at the Mbolet fish farm in Lambaréné in Gabon in order to evaluate the growth and reproductive performance of these two species. Methods: For this purpose, 226 fish (113 of T. cabrae with an average weight of 30.55±9.5 g and 113 O. schwebischi with an average weight of 20.64±10.5 g), were distributed in four 6 m2 tanks with two replicates per species for the growing phase which lasted 60 days. For the reproductive phase, 42 selected mature fish, including 6 males and 36 females of each species, were placed in six 2 m2 ponds with three replicates per species for 78 days. Result: The survival rate, the number of reproductions per species and the absolute, relative and system productivities were determined. It was found that the average weight gain, daily individual growth and specific growth rate were significantly (p less than 0.05) higher in T. cabrae, 48.1±5.51 g, 0.8±0.092 g/day and 1.57±0.066% g/day respectively, than in O. schwebischi, 27.11±9.23 g, 0.45±0.15 g/day and 1.38±0.051% g/day respectively. At the end of reproduction, the absolute productivity of T. cabrae (234.75±24.71 larvae/female/egg-laying) was significantly higher (p less than 0.05) than that of O. schwebichi (104.68±46.64 larvae/female/laying). System productivity was significantly higher (p less than 0.05) in O. schwebichi (11.34±2.29 larvae/m2/day) compared to that of T. cabrae (4.12±1.73 larvae/m2/day). Thus, on a fish farm, the use of these species may be possible.