biological individuality
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Author(s):  
Timothy M. Ghaly ◽  
Michael R. Gillings

Mobile genetic elements (MGEs) are primary facilitators in the global spread of antibiotic resistance. Here, we present novel ecological and evolutionary perspectives to understand and manage these elements: as selfish entities that exhibit biological individuality, as pollutants that replicate and as invasive species that thrive under human impact. Importantly, each viewpoint suggests new means to control their activity and spread. When seen as biological individuals, MGEs can be regarded as therapeutic targets in their own right. We highlight promising conjugation-inhibiting compounds that could be administered alongside antibiotic treatment. Viewed as pollutants, sewage treatment methods could be modified to efficiently remove antimicrobials and the resistance genes that they select. Finally, by recognizing the invasive characteristics of MGEs, we might apply strategies developed for the management of invasive species. These include environmental restoration to reduce antimicrobial selection, early detection to help inform appropriate antibiotic usage, and biocontrol strategies that target MGEs, constituting precision antimicrobials. These actions, which embody the One Health approach, target different characteristics of MGEs that are pertinent at the cellular, community, landscape and global levels. The strategies could act on multiple fronts and, together, might provide a more fruitful means to combat the global resistance crisis. This article is part of the theme issue ‘The secret lives of microbial mobile genetic elements’.


2021 ◽  
Author(s):  
Seyed Alireza Zamani-Dahaj ◽  
Anthony Burnetti ◽  
Thomas Day ◽  
william C Ratcliff ◽  
Peter J. Yunker ◽  
...  

The Major Transitions in evolution include events and processes that result in the emergence of new levels of biological individuality. For collectives to undergo Darwinian evolution, their traits must be heritable, but the emergence of higher-level heritability is poorly understood and has long been considered a stumbling block for nascent evolutionary transitions. A change in the means by which genetic information is utilized and transmitted has been presumed necessary. Using analytical models, synthetic biology, and biologically-informed simulations, we explored the emergence of trait heritability during the evolution of multicellularity. Contrary to existing theory, we show that no additional layer of genetic regulation is necessary for traits of nascent multicellular organisms to become heritable; rather, heritability and the capacity to respond to natural selection on multicellular-level traits can arise ''for free.'' In fact, we find that a key emergent multicellular trait, organism size at reproduction, is usually more heritable than the underlying cell-level trait upon which it is based, given reasonable assumptions.


2021 ◽  
Vol 36 (2) ◽  
Author(s):  
Marie I. Kaiser ◽  
Rose Trappes

AbstractBiological individuality is a notoriously thorny topic for biologists and philosophers of biology. In this paper we argue that biological individuality presents multiple, interconnected questions for biologists and philosophers that together form a problem agenda. Using a case study of an interdisciplinary research group in ecology, behavioral and evolutionary biology, we claim that a debate on biological individuality that seeks to account for diverse practices in the biological sciences should be broadened to include and give prominence to questions about uniqueness and temporality. We show that broadening the problem agenda of biological individuality draws attention to underrecognized philosophical issues and discussions and thereby organizes and enriches the existing debate.


2021 ◽  
Vol 11 ◽  
Author(s):  
Laura Nuño de la Rosa ◽  
Mihaela Pavličev ◽  
Arantza Etxeberria

Criticisms of the “container” model of pregnancy picturing female and embryo as separate entities multiply in various philosophical and scientific contexts during the last decades. In this paper, we examine how this model underlies received views of pregnancy in evolutionary biology, in the characterization of the transition from oviparity to viviparity in mammals and in the selectionist explanations of pregnancy as an evolutionary strategy. In contrast, recent evo-devo studies on eutherian reproduction, including the role of inflammation and new maternal cell types, gather evidence in favor of considering pregnancy as an evolved relational novelty. Our thesis is that from this perspective we can identify the emergence of a new historical individual in evolution. In evo-devo, historical units are conceptualized as evolved entities which fulfill two main criteria, their continuous persistence and their non-exchangeability. As pregnancy can be individuated in this way, we contend that pregnant females are historical individuals. We argue that historical individuality differs from, and coexists with, other views of biological individuality as applied to pregnancy (the physiological, the evolutionary and the ecological one), but brings forward an important new insight which might help dissolve misguided conceptions.


2020 ◽  
Vol 87 (5) ◽  
pp. 1037-1048
Author(s):  
Elselijn Kingma

2020 ◽  
Vol 14 (3) ◽  
pp. 402-432
Author(s):  
Tano Posteraro

This paper introduces Deleuze and Guattari's assemblage theory into the contemporary biological context. I begin by laying out at some length what I take to be the defining features of Deleuze and Guattari's theory of assemblage. I consider this to be a worthwhile endeavour in its own right, and so dedicate a large portion of this paper to producing a clear account of what it is that characterises an assemblage. Then I provide a reading of Deleuze and Guattari's critical conception of the organism as a kind of assemblage typified by an especially restrictive, self-regulating form of functional integration. This restrictiveness comprises what I take to be the first pole of organic life. Then I reconsider Deleuze and Guattari's positive comments about ‘non-organic life’ in this context, as a feature internal to the organisation of organic life instead of something to be set against it. I theorise this mostly in terms of symbiosis. I take the significance of symbiosis, consisting in what Deleuze and Guattari call ‘shared deterritorialisation’, to comprise the second pole of organic life. I conclude the paper with a brief discussion of how Deleuze and Guattari's assemblage-based conception of organism might be thought to anticipate and accommodate some of the contemporary research on biological individuality.


Author(s):  
Isaac Hernández ◽  
Davide Vecchi

In this article we focus on the emergence of biological individuality by association, trying to formulate some theoretical conditions to think about the process of collective individualization. The starting point of our analysis is the notion of “major evolutionary transition.” A major evolutionary transition is the result of the integration of a multiplicity of initially independent biological entities that, by managing to organize their interactions, become a collective of components having an identity oriented towards a common goal. When biological organisms (sometimes belonging to different lineages) are concerned, a major transition corresponds to a phenomenon of fusion between them. We shall argue that the emergence of a new biological level of individuality implies the establishment of constitutive relationships between individuals that change their status as autonomous entities. As a result, the emergence of a new type of entity in the living world implies that individuals enter into relationships that intrinsically transform them, a transformation sufficient for a “whole” to become a “part” that forms another “whole”, that is, a new level of organismality. 


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