The present chapter argues that, to harness the benefits of technology in the digital age, while mitigating the inherent security risks, it has become more pressing than ever to break down siloes between expert communities. Top-down governance alone cannot address all the security risks. Greater attention needs to be paid to horizontal governance mechanisms that bring together policymakers, the private sector, communities of users, law enforcement officials, and scientists. A holistic approach calls for an equal focus on anticipating the risks, seeking to prevent their occurrence, and building systemic capacities to recover from them. The chapter starts by discussing two illustrative security dilemmas—the first is about publishing scientific knowledge in the digital age and the second is the challenge posed by additive manufacturing. It then examines the limits of regulatory approaches to the proliferation of technologies of concern. Next, it presents an argument for an adaptation of norms, policy instruments, and governance institutions to enable societies to continue to enjoy the benefits of science and technology, while mitigating their risks. It concludes by giving examples of horizontal governance mechanisms that bring together policymakers, communities of users, law enforcement officials, and scientists, and by suggesting that such models should become more commonplace to inform government policies.