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Author(s):  
Usha N S ◽  
Sushmitha H S ◽  
Vinay Kumar G

Background: The world is in the midst of a COVID-19 Pandemic. While countries, including India, have taken strong measures to control the spread of COVID-19 through better diagnostics and treatment. Vaccines will provide a lasting solution by enhancing Immunity and containing the disease spread. COVID-19 vaccine has been rolled out recently in several parts of the world. Although the protective efficiency is frequently discussed, little is known about the real-world post-vaccination experience outside of clinical trial conditions. Knowledge about what to expect after vaccination will help educate the public, dispel misinformation and reduce vaccine hesitancy. Objectives: To assess the immediate response to the first dose of Covid- 19 vaccine and to study the side effects of Covid- 19 vaccination. Results: Results of the study revealed that 143(95.3%) participants are not developed any side effects, only 7 (4.66%) participants reported mild side effects within 30 minutes after vaccination, 104 (69.33%) participants are developed mild side effects like fever, body pain after 30 minutes to 24 hours, 14 (9.33%) participants are developed side effects in mild form after 24 hours, only 2(1.33%) participants are developed side effects like mild fever and fatigue after 1 week of vaccination, majority of the participants 149 (99.33%) didn't required any hospitalization and only 1 participant (0.66% ) admitted to hospital due to fever for one day, majority of participants 63 (42%) are recovered from side effects within 24 hours, 28 (18.66%) participants are recovered within 2 to 8 hours, 14 (9.3%) participants are recovered within 2 hours, 4 (2.66%)participants are recovered within 8 to 24hours and 41 (27.3%) participants are recovered after 24 hours. All the participants are willing to take 2nd dose and recommend for their family members and friends to get vaccination.


2021 ◽  
pp. 823-827
Author(s):  
N.N. Dubenok ◽  
A.I. Petelko ◽  
A.I. Petelko

Novosilskaya zonal agroforestry experimental station was founded in 1921 for development measures to combat water erosion. In the article, the authors carried out the research to identify the soil-protective efficiency of agroforestry-meadow reclamation measures of the anti-erosion complex. The creation of spruce strips around the meadows, on the slope lands of the Glubkovsky dry fields contributed to a radical change in the soil cover: an increase in the humus horizon, the content of humus, and a decrease in the bulk mass. The studied anti-erosion measures had a positive effect on the fertility of illuvial soils.


Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1097
Author(s):  
Dominika Święch ◽  
Gaetano Palumbo ◽  
Natalia Piergies ◽  
Ewa Pięta ◽  
Aleksandra Szkudlarek ◽  
...  

In this paper, the conformational changes of tryptophan (Trp) on the corroded 316 L stainless steel (SS) surface obtained under controlled simulated inflammatory conditions have been studied by Raman (RS) and Fourier-transform infrared (FT-IR) spectroscopy methods. The corrosion behavior and protective efficiency of the investigated samples were performed using the potentiodynamic polarization (PDP) technique in phosphate-buffered saline (PBS) solution acidified to pH 3.0 at 37 °C in the presence and absence of 10−2 M Trp, with different immersion times (2 h and 24 h). The amino acid is adsorbed onto the corroded SS surface mainly through the lone electron pair of the nitrogen atom of the indole ring, which adopts a more/less tilted orientation, and the protonated amine group. The visible differences in the intensity of the Fermi doublet upon adsorption of Trp onto the corroded SS surface, which is a sensitive marker of the local environment, suggested that a stronger hydrophobic environment is observed. This may result in an improvement of the corrosion resistance, after 2 h than 24 h of exposure time. The electrochemical results confirm this statement—the inhibition efficiency of Trp, acting as a mixed-type inhibitor, is made drastically higher after a short period of immersion.


Author(s):  
Runeva V. Olga ◽  
Liudmila A. Napisanova ◽  
Vera K. BEREZHKO

Trichinellosis caused by the gastrointestinal nematode Trichinella spiralis occurs in humans, domestic animals and wild animals. This heavy ubiquitous parasitic disease. The muscle phase of the parasite of difficult to controlling. Homeopathic drugs such as Cina have anthelmintic and immunostimulation properties. The purpose of this study was assess the protective efficiency of homeopathic drug such as Cina C6cH and Roncoleukin ® (recombinant interleukin-2 (rIL-2) immunostimulation) against experimental trichinosis, that can affect the muscle phase of the parasite T. spiralis in mice. An assay was carried out on 30 white outbred mice. These were divided into tree groups of ten mice each. The group 1 were treated with the Roncoleukin ® (100 IU/per mouse in 0,2 ml sterile saline intramuscularly, twice with 48 hours intervals); the group 2 - desoldering dissolved in water Cina C6cH (under the scheme). The group 3 received 0.2 ml of sterile 0.9% NaCl. After a 21 day regimen, the groups were inoculated with a dose of 80 ± 5 units of Trihinella spiralis larva per mouse. After 90 days of incubation, the mice were euthanized and dissected for evaluation. The maximum protection was obtained in mice immunized with Roncoleukin ® (80,61%; 869,5±16,6 larva/per animal). The protective effect in the group immunized by Cina C6cH was of 36,67 ( (2840,5±183,3 larva/per animal)%. In control group invasion on muscle phase T.spiralis was 4485±430,6 larva/per animal/ In conclusion, the use of homeopathic drugs also reduces in the number of infective Trichinella spiralis larvae in mice and has a synergistic effect on the treatment.


2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Yanhong Wang ◽  
Juanjuan Wang ◽  
Jia Yang ◽  
Jing Kang ◽  
Fuping Xue ◽  
...  

Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally administrated by intravenous infusion which is liable to cause serious phlebitis. The therapeutic drugs for preventing this complication are limited. Intermedin (IMD), a member of calcitonin family, has a broad spectrum of biological effects including anti-inflammatory effects, antioxidant activities, and antiapoptosis. But now, the protective effects of IMD against amiodarone-induced phlebitis and the underlying molecular mechanism are not well understood. In this study, the aim was to investigate the protective efficiency and potential mechanisms of IMD in amiodarone-induced phlebitis. The results of this study revealed that treatment with IMD obviously attenuated apoptosis and exfoliation of vascular endothelial cells and infiltration of inflammatory cells in the rabbit model of phlebitis induced by intravenous infusion of amiodarone compared with control. Further tests in vitro demonstrated that IMD lessened amiodarone-induced endothelial cell apoptosis, improved amiodarone-induced oxidative stress injury, reduced inflammatory reaction, and activated the Wnt/β-catenin signal pathway which was inhibited by amiodarone. And these effects could be reversed by Wnt/β-catenin inhibitor IWR-1-endo, and si-RNA knocked down the gene of Wnt pathway. These results suggested that IMD exerted the protective effects against amiodarone-induced endothelial injury via activating the Wnt/β-catenin pathway. Thus, IMD could be used as a potential agent for the treatment of phlebitis.


Author(s):  
Runeva Olga ◽  
Napisanova Liudmila ◽  
Zhdanova Olga ◽  
Berezhko Vera

The purpose of this study was assess the protective efficiency of homeopathic drug such as Cina C6cH and meglumineacridonacetate(cycloferon) against experimental trichinosis, that can affect the muscle phase of the parasite T. spiralis in mice. The maximum protection was obtained in mice immunized with cycloferon, the number of T. spiralis larvae detected in animals was 733.5±25.1 larva/per animal. The number of larvae detected in the group immunized by Cina C6cH was 2840,5±183,3. This was 6.1 and 1.6 times less than in the mice of control group (4485±430.6 larvae/mouse).


Author(s):  
Olga Zhdanova ◽  
O.V. Rudneva ◽  
J.K. Akulinina ◽  
L.A. Napisanova

Immunostimulatory drugs in recent years are widely used in Parasitology. Also, homeopathic drugs such as Cina have anti-helmintic and immunostimulation properties. We studied the possibility of using immunostimulating and high dilutions drugs during parasitological disease treatment. Two experimental parasitological disease models (trichinelosis and cutaneous leishmaniosis) were used. Trichinellosis caused by gastrointestinal nematode Trichinella spiralis occurs in humans, domestic and wild animals. Leishmaniasis is a disease caused by parasites of Leishmania genus. It is spread by certain sandflies types bite. The disease can present in three main ways. We used 2 leishmania in vitro models and experimental mice cutaneous model. The cutaneous form presents skin ulcers, while the mucocutaneous form presents skin, mouth, and nose ulcers. For estimation of immunostimulatory efficacy, size of leishmanioma, presence of leishmania in the ulcer, and treatment time were analyzed. This study aimed at to assess the protective efficiency of homeopathic drug such as Cina C6cH and interferon 2 and inductors of interferons of types 1 and 2 interferon, against experimental trichinosis and leichmaniosis. An assay was carried out on 50 white outbred mice. These were divided into three groups of ten mice each. Group 1 was injected with interferon inductors (2.16 mg/mouse in 0.2 ml sterile saline, intramuscularly); group 2 - desoldering dissolved in water Cina C6cH one time a day per os. The group 3 received interferone-a2b; and the group 4 was injected 0.2 ml of sterile 0.9% NaCl. The group 5 was only for leishmaniasis. After a 48 hours regimen, the groups 1-3 were inoculated with a dose of 80 ± 5 units of T. spiralis larva per mouse. After 90 days of trichinellosis incubation, and during one year of leishmaniasis process the mice were euthanized and dissected for evaluation. Maximum protection was obtained in mice immunized with interferon-a2b and its stimulatory, as T. spiralis detected larvae in animals was 733.5±25.1 larva/animal. Cina C6cH immunized group presented 2840.5±183.3 larva/animal. This was less than control group (4485±430.6 larva/mouse). Also mice with leishmaniasis had fewer ulcers during treatment with immune stimulating. Ulcers sizes were 0.46+0.05 (group 3); 2.2 +0.5 (group 2), and 3.2+0.8 (group 5). Leishmanial amount in the ulcer was 3.1 +0.7(group 3), 3.6 +0.4 (group 2), and 3.7+0.3(goup 5). The time of the treatment in the 3-d group was 19.2+0.9 and more than 40 days in all group (2,4,5). So, based on this, we consider it advantageous to continue the study of immunostimulatory drugs in the complex treatment of trichinelosis and leishmaniosis.


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