Autoimmune Polyglandular Syndrome Type 3-D

Background: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against cell nuclei and involves many organ systems in the body. The etiopathology of SLE is thought to involve complex and multifactorial interactions between genetic variation and environmental factors. Hyperthyroidism is a disease due to increased thyroid hormone function followed by signs and symptoms that affect the body's metabolic system. Graves' disease is an autoimmune disease characterized by the presence of antibodies to TSHR (TRAb). Several coexisting autoimmune diseases have been classified under different syndromes. Case Presentation: A woman, 29 years-old, came to office with complaint of chest palpitation. Patient had history of fever, joint pain, hair loss, and malar rash. Patient had been diagnosed with hyperthyroidism for 4 years and regularly taking propylthiouracil 100 mg and propranolol 10 mg. Titer ANA Test 1/100, Anti ds-DNA 68.08, C3-Complement 93 (N: 83-193), C4-Complement 11.2 (N: 15-57), Free T3 7.79 (N: 1.71-3.71), Free -T4 2.50 (N: 0.70-1.48), TSHs 0.0001 (N: 0.350-4.94), TRAb 3.38 (N: < 1.75). Patient was diagnosed with systemic lupus erythematosus (SLE) and graves’ disease. Patient treated with methimazole 10 mg, propranolol 10 mg, myfortic 360 mg, and methylprednisolone 4 mg. Conclusion: Autoimmune Polyendocrine Syndromes (APS) was at first characterized as different endocrine organ diseases related to an immune system disease in a subject. Hence, affiliation between illnesses in APS was noted not to be irregular but in specific combinations in which a few non-endocrine immune system diseases were moreover portion of the disorders.

Zinc Homeostasis in Diabetes Mellitus and Vascular Complications

Oxidative stress represents an impaired metabolic system that promotes damage to cells and tissues. This is the predominant factor that leads to the development and progression of diabetes and diabetic complications. Research has indicated that zinc plays a consequential mechanistic role in the protection against oxidative stress as zinc is required for the proper functioning of the antioxidant system, the suppression of inflammatory mediators, and the modulation of zinc transporters. Recently, the mechanisms surrounding ZnT8, ZIP7, and metallothionein have shown to be of particular pathogenic importance and are considered as potential therapeutic targets in disease management. The literature has shown that zinc dysregulation is associated with diabetes and may be considered as a leading contributor to the deleterious vascular alterations exhibited by the disease. Although further investigation is required, studies have indicated the favorable use of zinc supplementation in the protection against and prevention of oxidative stress and its consequences over the course of the condition. This review aims to provide a comprehensive account of zinc homeostasis, the oxidative mechanisms governed by zinc status, current therapeutic targets, and the impact of zinc supplementation in the prevention of disease onset and in mitigating vascular complications.

Polyglandular Autoimmune Syndrome Type 3D : A Case Report

Background: Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by the presence of autoantibodies against cell nuclei and involves many organ systems in the body. The etiopathology of SLE is thought to involve complex and multifactorial interactions between genetic variation and environmental factors. Hyperthyroidism is a disease due to increased thyroid hormone function followed by signs and symptoms that affect the body's metabolic system. Graves' disease is an autoimmune disease characterized by the presence of antibodies to TSHR (TRAb). Several coexisting autoimmune diseases have been classified under different syndromes. Autoimmune Polyglandular Syndrome (PGAS),Case Presentation: A woman, 29 years-old, came to office with complaint of chest palpitation. Patient had history of fever, joint pain, hair loss, and malar rash. Patient had been diagnosed with hyperthyroidism for 4 years and regularly taking propylthiouracil 100 mg and propranolol 10 mg. Titer ANA Test 1/100, Anti ds-DNA 68.08, C3-Complement 93 (N: 83-193), C4-Complement 11.2 (N: 15-57), Free T3 7.79 (N: 1.71-3.71), Free -T4 2.50 (N: 0.70-1.48), TSHs 0.0001 (N: 0.350-4.94), TRAb 3.38 (N: &lt; 1.75). Patient was diagnosed with systemic lupus erythematosus (SLE) and grave's disease. Patient treated with methimazole 10 mg, propranolol 10 mg, myfortic 360 mg, and methylprednisolone 4 mg.Conclusion: Autoimmune Polyendocrine Syndromes (APS) was at first characterized as different endocrine organ diseases related to an immune system disease in a subject. Hence, affiliation between illnesses in APS was noted not to be irregular but in specific combinations in which a few non-endocrine immune system diseases were moreover portion of the disorders.

A STUDY ON THE INCIDENCE OF GOALS AND THE RELATIONSHIP BETWEEN SCORING THE FIRST GOAL AND WINNING THE MATCH IN THE HUNGARIAN BEACH SOCCER CHAMPIONSHIP

Although beach soccer has become increasingly popular in recent years an only a minimal number of scientific research has been conducted in this area. The beach soccer is characterized by high intensity (HR max above 90 %) intermittent movements, which primarily requires the involvement of the anaerobic metabolic system. The objective of this study was: (i) to analyze the incidence of goals in the Hungarian Beach Soccer Championship in relation to the periods of the game that tend to occur; (ii) to identify the team that scored the first goal of the game, analyzing the influence of this event on the final result (iii) to identify and quantify the periods of the match won by the winner team. We examined all the goals (n = 1.065) in the Hungarian Championship (2016-2017) of beach soccer. We found that nearly 38 percent of goals are scored in the last period of the matches, the team that scores the first goal of the game features an average 74.44 percent probability of winning. We observed, that almost 24 percent of the teams, which achieved overall success also earned the 1st and 3rd periods. Thus, it is suggested that the higher incidence of goals in the 3rd period of the matches is associated mainly with the interaction of physical and psychological factors. Regarding the influence of the first goal on the final result, we assumed that the psychological factor appears to interfere with greater relevance.

Quercetin Modulates Behavioural and Biochemical Alterations in Stressed Mice

Disruption of the active phase of sleep alters the physiological homeostasis of the body and results in oxidative breakdown which may trigger a wide array of defects. The central nervous system and the metabolic system are some of the most affected systems as described in several literatures. Some plant based compounds with antioxidant property have been previously described in the abrogation of the deleterious effects of active sleep disruption. One of such compounds is quercetin. This study was premeditated to expatiate on the probable neuroprotective effect of quercetin on mice exposed to 72hr active sleep disruption. Mice were allotted into five treatment groups (n = 6): group 1 served as control, group 2 received 10 mL/kg vehicle, groups 3 and 4 received 25 and 50 mg/kg quercetin respectively, and group 5 received 50 mg/kg astaxanthin. Treatment lasted for 7 days while groups 2-5 were exposed to the sleep deprivation protocol starting from day 4. Behavioural tests followed by biochemical assays and histopathological changes in the prefrontal cortex were evaluated. Data were analysed by ANOVA set at p<0.05 significance. The results revealed that quercetin, in both doses, significantly amplified memory performance, attenuated depression-like behaviour, replenished catalase and superoxide dismutase, attenuated nitric oxide levels in brain and liver of mice when compared to control group and protected against loss of prefrontal cortex neurons. In conclusion, quercetin possesses protective effects against sleep deprivation-induced brain damage.

REVIEW ON PHYSIOLOGICAL EVALUATION OF ABHYANGA

Lifestyle interventions are the major Ayurvedic preventive and therapeutic approach that helps in building a healthy metabolic system, attaining good digestion and proper excretion. To achieve the aim of Ayurveda, i.e., to preserve and promote the health of healthy, it prescribes many measures in the form of daily routine [Dinacharya], seasonal regime [Rtu charya] etc. Abhyanga has been included as a part of Dinacharya and as a treatment for certain diseases. It is also a part of the pre-therapeutic procedures of Panchakarma (five purificatory measures). It prevents Jara [ageing process], help to overcome Srama [fatigue], cures disease caused by Vata, promotes eyesight, improves texture and quality of skin, longevity etc. Since Vata dominates in the Sparsanendriya (skin) and Taila (oil) possess those qualities opposite to that of Vata, Abhyanga pacify Vata to a great extent. Since Sparsha is also the seat of Pitta dosha, and the eye itself is the seat of Pitta, Drshtiprasada effect of Abhyanga described in classics can be explained. By massaging, through oil application and generating heat by friction, Abhyanga stimulate blood circu- lation and lymphatic circulation. It also serves as the transporting medium of nutritional substances, metabolic end- products etc. So, it is an attempt to explore the physiological effects of Abhyanga as Dinacharya in the body. Keywords: Abhyanga, Pancha karma, Physiology

Detoxification II Prescription Suppresses the Th-17/IL-17 Inflammatory Axis to Improve the Liver Function of ACLF-Rats via Inactivating the P38MAPK Pathway

Hepatitis is a metabolic system disease which is a serious challenge to the medical and healthcare system of the world. This study attempted to investigate the therapeutic effect and illustrate the regulation pharmacological mechanism of Detoxification II Prescription on ACLF. In this study, the rats were injected with D-galactosamine to establish ACLF-rat models, and the levels of cholinesterase (CHE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (ALB), and total bilirubin (TBiL) were measured with the related kits to reflect the liver functions of the rats. The levels of IL-17, IL-6, and IFN-γ in the serums of the rats were detected by qRT-PCR, and the percentages of Th-17 cells in CD4+ cells of the rats were measured by flow cytometry assay. In the results, the increased ALT, AST, TBiL, IL-6, IL-17, IFN-γ, and percentage of Th-17 cells in CD4+ and decreased ALB and CHE were found in the serums of the ACLF-rats, while Detoxification II Prescription could partly reverse those indexes of the ACLF-rats. Moreover, it was also found that Detoxification II Prescription could inhibit the expression of P38MAPK, and P38MAPK downregulation obviously improved the liver function indexes of the ACLF-rats including the levels of ALT, AST, TBiL, IL-6, IL-17, IFN-γ, and percentage of Th-17 cells in CD4+ cells. In conclusion, this study suggested that Detoxification II Prescription could suppress the Th-17/IL-17 inflammatory axis to improve the liver function of ACLF-rats via inhibiting the activity of the P38MAPK pathway.

Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action

Adult and childhood obesity have reached pandemic level proportions. The idea that caloric excess and insufficient levels of physical activity leads to obesity is a commonly accepted answer for unwanted weight gain. This paradigm offers an inconclusive explanation as the world continually moves towards an unhealthier and heavier existence irrespective of energy balance. Endocrine disrupting chemicals (EDCs) are chemicals that resemble natural hormones and disrupt endocrine function by interfering with the body’s endogenous hormones. A subset of EDCs called obesogens have been found to cause metabolic disruptions such as increased fat storage, in vivo. Obesogens act on the metabolic system through multiple avenues and have been found to affect the homeostasis of a variety of systems such as the gut microbiome and adipose tissue functioning. Obesogenic compounds have been shown to cause metabolic disturbances later in life that can even pass into multiple future generations, post exposure. The rising rates of obesity and related metabolic disease are demanding increasing attention on chemical screening efforts and worldwide preventative strategies to keep the public and future generations safe. This review addresses the most current findings on known obesogens and their effects on the metabolic system, the mechanisms of action through which they act upon, and the screening efforts through which they were identified with. The interplay between obesogens, brown adipose tissue, and the gut microbiome are major topics that will be covered.

NEW GENERATION ADAPTED MILK FORMULAS PRODUCED BY UKRAINIAN MANUFACTURERS FOR FEEDING INFANTS UNDER ONE YEAR

Breastfeeding is known as the only one form of human feeding that formed during the biological evolution. However, when breastfeeding is impossible, the only solution is to use modern adapted milk formulas to nourish infants. One of the most challenging issues is the adaptation of the formula protein quantity and quality to those in breast milk. Reducing the protein content in the adapted formula "Malutka Premium" prevents protein overload of the immature metabolic system of the child. Fats also play an important role in the nutrition of children as they perform two main functions in the body: they serve as structural components of biological cell membranes and energy material. The fatty component of "Malutka Premium" adapted formula is represented by 50% vegetable oils, which provides the required level of polyunsaturated fatty acids. The carbohydrate component of the adapted formula "Malutka Premium1" is represented by lactose; the adapted formula "Malutka Premium 2" also contains dextrinmaltose (30%). Prebiotics oligosaccharides and five most important nucleotides are added to the composition of "Malutka Premium" that enables to normalize the composition of the intestinal microflora and to intensify the digestive processes. Clinical observations of children receiving formulas with oligosaccharides and nucleotides have shown their high efficacy. Children gained weight better and were found as less likely to have functional digestive disorders. Introducing "Malutka premium with the addition of cereals" formulas to the child's diet enables to choose the most appropriate formula taking into account the peculiarities of the child's digestion. Feeding infants with domestic milk formula ensures the balanced intake of all necessary substances required in accordance with the age and allows to parents and paediatricians solve many problems in the nutrition of both healthy children and children with special nutritional needs.

Temporal convolutional networks predict dynamic oxygen uptake response from wearable sensors across exercise intensities

Oxygen consumption ($$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 ) provides established clinical and physiological indicators of cardiorespiratory function and exercise capacity. However, $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 monitoring is largely limited to specialized laboratory settings, making its widespread monitoring elusive. Here we investigate temporal prediction of $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 from wearable sensors during cycle ergometer exercise using a temporal convolutional network (TCN). Cardiorespiratory signals were acquired from a smart shirt with integrated textile sensors alongside ground-truth $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 from a metabolic system on 22 young healthy adults. Participants performed one ramp-incremental and three pseudorandom binary sequence exercise protocols to assess a range of $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 dynamics. A TCN model was developed using causal convolutions across an effective history length to model the time-dependent nature of $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 . Optimal history length was determined through minimum validation loss across hyperparameter values. The best performing model encoded 218 s history length (TCN-VO2 A), with 187, 97, and 76 s yielding <3% deviation from the optimal validation loss. TCN-VO2 A showed strong prediction accuracy (mean, 95% CI) across all exercise intensities (−22 ml min−1, [−262, 218]), spanning transitions from low–moderate (−23 ml min−1, [−250, 204]), low–high (14 ml min−1, [−252, 280]), ventilatory threshold–high (−49 ml min−1, [−274, 176]), and maximal (−32 ml min−1, [−261, 197]) exercise. Second-by-second classification of physical activity across 16,090 s of predicted $$\dot{\,{{\mbox{V}}}}{{{\mbox{O}}}}_{2}$$ V ̇ O 2 was able to discern between vigorous, moderate, and light activity with high accuracy (94.1%). This system enables quantitative aerobic activity monitoring in non-laboratory settings, when combined with tidal volume and heart rate reserve calibration, across a range of exercise intensities using wearable sensors for monitoring exercise prescription adherence and personal fitness.