ablation efficiency
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2022 ◽  
Vol 19 (2) ◽  
pp. 026001
Author(s):  
N A Smirnov ◽  
S I Kudryashov ◽  
А А Rudenko ◽  
A A Nastulyavichus ◽  
A A Ionin

Abstract A comparison of single-pulse laser ablation of gold target by pulses with a 0.3–10 ps duration and a wavelength of 515 nm in air and in water was performed. The radiation was focused on the sample surface through the objectives with numerical apertures NA = 0.65 and 0.25. The influence of the medium, pulse duration, and spot size on the crater morphology was studied. A significant difference in crater morphology was found for different lenses. The ablation efficiency was studied by measuring the profiles of single-shot pulse craters using scanning force microscopy. The contribution of filamentation to the ablation process is shown quantitatively.


2022 ◽  
Vol 12 ◽  
Author(s):  
Sarah R. Gutbrod ◽  
Allan Shuros ◽  
Vijay Koya ◽  
Michelle Alexander-Curtis ◽  
Lauren Lehn ◽  
...  

Background: The purpose of this study was to assess the effect local impedance (LI) has on an ablation workflow when combined with a contact force (CF) ablation catheter.Methods: Left pulmonary vein isolation was performed in an in vivo canine model (N = 8) using a nominal (30 W) or an elevated (50 W) power strategy with a CF catheter. The catheter was enabled to measure LI prior to and during ablation. LI was visible for only one of the vein isolations.Results: Chronic block was achieved in all animals when assessed 30 ± 5 days post-ablation procedure with a median LI drop during RF ranging from 23.0 to 34.0 Ω. In both power cohorts, the median radiofrequency (RF) duration decreased if LI was visible to the operator (30 W only CF: 17.0 s; 30 W CF + LI: 14.0 s, p = 0.009; 50 W only CF: 6.0 s; 50 W CF + LI: 4.0 s, p = 0.019). An inverse relationship between the LI prior to RF delivery and the RF duration required to achieve an effective lesion was observed. There was no correlation between the magnitude of the applied force and the drop in LI, once at least 5 g was achieved.Conclusions: An elevated power strategy with the context of CF and LI led to the most efficient titration of successful RF energy delivery. The combination of feedback allows for customization of the ablation strategy based on local tissue variation rather than a uniform approach that could potentially lead to overtreatment. Higher LI drops were more readily achievable when an elevated power strategy was utilized, especially in conditions where the catheter was coupled against tissue with low resistivity. Clinical study is warranted to determine if there is an additive safety benefit to visualizing the dynamics of the tissue response to RF energy with LI when an elevated power strategy is used.


Photonics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 20
Author(s):  
Mariya S. Kopyeva ◽  
Serafima A. Filatova ◽  
Vladimir A. Kamynin ◽  
Anton I. Trikshev ◽  
Elizaveta I. Kozlikina ◽  
...  

We present the results on the interaction of an all-fiber Holmium-doped laser CW radiation at a wavelength of 2100 nm with soft tissues and compare it with the other results obtained by the most used solid-state laser systems. Ex-vivo single spot experiments were carried out on the porcine longissimus muscles by varying the laser impact parameters in a wide range (average output power 0.3, 0.5 and 1.1 W; exposure time 5, 30 and 60 s). Evaluation of the laser radiation exposure was carried out by the size of coagulation and ablation zones on the morphological study. Exposure to a power of 0.3 W (1.5–18 J of applied energy) caused only reversible changes in the tissues. The highest applied energy of 66 J for 1.1 W and a 60-s exposure resulted in a maximum ablation depth of approximately 1.2 mm, with an ablation efficiency of 35%. We have shown that it is not necessary to use high powers of CW radiation, such as 5–10 W in the solid-state systems to provide the destructive effects. Similar results can be achieved at lower powers using the simple all-fiber Holmium laser based on the standard single-mode fiber, which could provide higher power densities and be more convenient to manufacture and use. The obtained results may be valuable as an additional experimental point in the field of existing results, which in the future will allow one to create a simple optimal laser system for medical purposes.


Author(s):  
Francesc Caballero-Lucas ◽  
Kotaro Obata ◽  
Koji Sugioka

Abstract Ultrashort laser pulses confine material processing to the laser-irradiated area by suppressing heat diffusion, resulting in precise ablation in diverse materials. However, challenges occur when high speed material removal and higher ablation efficiencies are required. Ultrafast burst mode laser ablation has been proposed as a successful method to overcome these limitations. Following this approach, we studied the influence of combining GHz bursts in MHz bursts, known as BiBurst mode, on ablation efficiency of silicon. BiBurst mode used in this study consists of multiple bursts happening at a repetition rate of 64 MHz, each of which contains multiple pulses with a repetition rate of 5 GHz. The obtained results show differences between BiBurst mode and conventional single pulse mode laser ablation, with a remarkable increase in ablation efficiency for the BiBurst mode, which under optimal conditions can ablate a volume 4.5 times larger than the single pulse mode ablation when delivering the same total energy in the process.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2183
Author(s):  
Sanjana Ghosh ◽  
Jonathan F. Lovell

Chemophototherapy is an emerging tumor ablation modality that can improve local delivery of chemotherapeutic agents. Long circulating doxorubicin (Dox) in porphyrin-phospholipid (PoP) liposomes (LC-Dox-PoP) has previously been developed as an effective chemophototherapy agent. In the present study, we observed that in mice, LC-Dox-PoP showed enhanced accumulation in human pancreatic tumor xenografts even with suboptimal light doses, as assessed by fluorometric analysis of tissue homogenates and microscopic imaging of Dox and PoP in tumor slices. A second laser treatment, at a time point in which tumors had greater drug accumulation as a result of the first laser treatment, induced potent tumor ablation. Efficacy studies were carried out in two human pancreatic cancer subcutaneous mouse tumor models; MIA PaCa-2 or low-passage patient derived pancreatic cancer xenografts. A single treatment of 3 mg/kg LC-Dox-PoP and an initial 150 J/cm2 laser treatment 1 h after drug administration, followed by second laser treatment of 50 J/cm2 8 h after drug administration, was more effective than a single laser treatment of 200 J/cm2 at either of those time points. Thus, this study presents proof-of-principle and rationale for using two discrete laser treatments to enhance the efficacy of chemophototherapy.


2021 ◽  
Vol 1135 (1) ◽  
pp. 012026
Author(s):  
Christian Lutz ◽  
Cemal Esen ◽  
Ralf Hellmann

Abstract We report on the effect of simultaneous spatial and temporal beam shaping on the ablation rate, ablation efficiency and the resulting surface characteristics of micromachined stainless steel using ultrashort-pulsed lasers. Beam shaping and the use of pulse bursts are promising methods to allocate the over the last decades increasing laser power of ultrashort-pulsed lasers in ablation processes. While the individual effects of beam shaping and pulse bursts on the ablation characteristics have recently been examined, the combination of both has not yet been adequately investigated. Using a spatial light modulator to generate different spot distributions with up to six spots and different separations it is possible to spatially distribute the available laser power. In combination with temporal beam shaping using a 200 kHz repetition rate and pulse bursts with a 40 MHz intra-burst rate, we investigate the influences in a scanning-based process and find an increasing ablation rate and efficiency for higher fluences. Subsequently using bursts in combination with a multi-spot beam profile, we found a distinctive emergence of cone like protrusions and a smoothing effect for fluences between 1.5 J/cm² and 3 J/cm² with six spot beam profile.


Author(s):  
Connor Edsall ◽  
Emerson Ham ◽  
Hal Holmes ◽  
Timothy L Hall ◽  
Eli Vlaisavljevich

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6355
Author(s):  
Kunpeng Chu ◽  
Baoshan Guo ◽  
Lan Jiang ◽  
Yanhong Hua ◽  
Shuai Gao ◽  
...  

In this study, femtosecond laser double pulses were tested to improve their nickel ablation efficiency. The experimental results indicated that compared with single pulses, double pulses with different delay times generated craters with larger diameters and depths. The results obtained for three sets of double pulses with different energy ratios indicated that double pulses with an energy ratio of 1:9 had the highest ablation efficiency, followed by those with energy ratios of 2:8 and 5:5. The double pulses with the aforementioned three energy ratios achieved the maximum ablation efficiency when the delay time was 3–4 ps. Compared with single pulses, double pulses with an energy ratio of 1:9 generated craters with an up to 34% greater depth and up to 14% larger diameter. In addition, an interference effect was observed with a double pulse delay time of 0 ps, which has seldom been reported in the literature. The double pulses were simulated using the two-temperature model. The simulation results indicated that double pulses with an energy ratio of 1:9 with a delay time of 4 ps can perform the strongest ablation. These simulation results are in line with the experimental results.


Materials ◽  
2021 ◽  
Vol 14 (19) ◽  
pp. 5544
Author(s):  
Niusha Lasemi ◽  
Günther Rupprechter ◽  
Gerhard Liedl ◽  
Dominik Eder

Scanning electron microscopy (SEM) and profilometry of the crater morphology and ablation efficiency upon femtosecond laser ablation of Au-coated Ni targets in various fluids revealed a pronounced dependence on the ablation medium. For ethanol, a sufficient ablation efficiency was obtained, whereas for 2-butanol a higher efficiency indicated stronger laser–target interaction. Hierarchical features in the crater periphery pointed to asymmetrical energy deposition or a residual effect of the Coulomb-explosion-initiating ablation. Significant beam deviation in 2-butanol caused maximum multiple scattering at the crater bottom. The highest values of microstrain and increased grain size, obtained from Williamson–Hall plots, indicated the superposition of mechanical stress, defect formation and propagation of fatigue cracks in the crater circumference. For n-hexane, deposition of frozen droplets in the outer crater region suggested a femtosecond-laser-induced phase explosion. A maximum ablation depth occurred in water, likely due to its high cooling efficiency. Grazing incidence micro X-ray diffraction (GIXRD) of the used target showed residual carbon and partial surface oxidation. The produced nanoparticle colloids were examined by multiangle dynamic light scattering (DLS), employing larger scattering angles for higher sensitivity toward smaller nanoparticles. The smallest nanoparticles were obtained in 2-butanol and ethanol. In n-hexane, floating carbon flakes originated from femtosecond-laser-induced solvent decomposition.


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