systemic lupus
Recently Published Documents


TOTAL DOCUMENTS

34221
(FIVE YEARS 6842)

H-INDEX

227
(FIVE YEARS 24)

2022 ◽  
Vol 44 (2) ◽  
pp. 127-132
Author(s):  
Hagar L. Mowafy ◽  
Maha M. Kotb ◽  
Kamal M. Hanna ◽  
Fatema T. Elgengehy ◽  
Lamiaa A. Madkour

2023 ◽  
Vol 83 ◽  
Author(s):  
L. M. Barbosa ◽  
M. B. Santiago ◽  
V. T. Moretto ◽  
D. Athanazio ◽  
D. Takahashi ◽  
...  

Abstract Toll-like receptor 9 (TLR9) is an important component of the innate immune system and have been associated with several autoimmune diseases, such as Systemic Lupus Erythematosus (SLE). The aim of this study was to investigate polymorphisms in TLR9 gene in a Brazilian SLE patients group and their association with clinical manifestation, particularly Jaccoud’s arthropathy (JA). We analyzed DNA samples from 204 SLE patients, having a subgroup of them presenting JA (n=24). A control group (n=133) from the same city was also included. TLR9 single nucleotide polymorphisms (SNPs) (−1237 C>T and +2848 G>A) were identified by sequencing analysis. The TLR9 gene genotype frequency was similar both in SLE patients and the control group. In the whole SLE population, an association between the homozygosis of allele C at position −1237 with psychosis and anemia (p < 0.01) was found. Likewise, the homozygosis of allele G at position +2848 was associated with a discoid rash (p < 0.05). There was no association between JA and TLR9 polymorphisms. These data show that TLR9 polymorphisms do not seem to be a predisposing factor for SLE in the Brazilian population, and that SNPs are not associated with JA.


2022 ◽  
Vol 44 (2) ◽  
pp. 121-125
Author(s):  
Fatma H. Abdelraouf ◽  
Manal E.S. Ramadan ◽  
Dina O. Abdulazim ◽  
AliGenena ◽  
Heba M. Selim

Sign in / Sign up

Export Citation Format

Share Document