dendritic polymer
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2021 ◽  
pp. 152221
Author(s):  
Pouyan Razmshoar ◽  
S. Hajir Bahrami ◽  
Mohammad Rabiee ◽  
Marie Hangouet ◽  
Marie Martin ◽  
...  
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Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6850
Author(s):  
Sozan Najib Abdullah ◽  
Georgia Mann ◽  
Lance J. Twyman

Being able to bind, select, and transport species is central to a number of fields, including medicine, materials, and environmental science. In particular, recognizing a specific species from one phase and transporting it across, or into another phase, has obvious applications in environ-mental science, for example, removal of unwanted or toxic materials from an aqueous or organic phase. In this paper, we describe an approach that uses a functionalized dendritic polymer to bind and transport a small anionic molecule across an organic phase (and between two aqueous phases). The design was based on encapsulation principles borrowed from nature, where anions are bound and transported by proteins that have specific sites within their globular ordered structures. For the work reported here, a globular dendritic polymer functionalized with an isophthalamide-based receptor was used to replace the protein structure and anion-binding site. Along with control experiments, the binding and transport properties of two functionalized HBPs were assessed using a Pressman U tube experiment. Both HBPs demonstrated an enhanced ability to bind and transport anions (when compared to the anion-binding site used in isolation). Furthermore, optimum binding and transport occurred when the smaller of the two HBPs were used. This supports our previous observations regarding the existence of a dense packed limit for HBPs.


2021 ◽  
pp. 2100330
Author(s):  
Lautaro Petrauskas ◽  
Matteo Cucchi ◽  
Christopher Grüner ◽  
Frank Ellinger ◽  
Karl Leo ◽  
...  

2021 ◽  
Author(s):  
Alain Fradet ◽  
Jiazhong Chen ◽  
Karl-Heinz Hellwich ◽  
Kazuyuki Horie ◽  
Jaroslav Kahovec ◽  
...  
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2021 ◽  
pp. 2100586
Author(s):  
Matteo Cucchi ◽  
Hans Kleemann ◽  
Hsin Tseng ◽  
Giuseppe Ciccone ◽  
Alexander Lee ◽  
...  

Author(s):  
Swapnil Rajput ◽  
Saurabh Muley ◽  
Ketan S. Kulkarni ◽  
Anant R. Kapdi ◽  
Anand V. Patwardhan

2021 ◽  
Author(s):  
Yunxia Wu ◽  
Qikang Wu ◽  
Yu Fu ◽  
Mingxing Huang ◽  
Zhijin Fan ◽  
...  

Abstract BackgroundEmerging infectious disease have brought a huge impact on human society in recent years. The outbreak of Zika virus (ZIKV) in the Americas resulted in a large number of babies born with microcephaly. More seriously, the Coronavirus Disease 2019 (COVID-19) caused the global spreads and immeasurable damages. Thus, the monitoring of highly pathogenic virus is of significance to the prevention and control of emerging infectious disease.ResultsHerein, a dendritic polymer probe-amplified ECL-scan imaging system was constructed to realize trace analysis of viral emerging infectious disease. Dendritic polymer probe was employed as the efficient signal giving-out component that could generate amplified electrochemiluminescence (ECL) signal on the integrated chip. And the signal was detected by a single-photon level charge coupled device-based ECL-scan imaging system. With this strategy,the ZIKV in the complex system of blood, urine and saliva were detected. The results indicated that high sensitivity of 50 copies and superior specificity were achieved. Furthermore, this strategy realized highly sensitive detection (10 copies) of S and N protein gene sequence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov2) and spiked pseudovirus samples.ConclusionsThus, the dendritic polymer probe-amplified ECL-scan imaging system suitably met the strict clinical-requirements for trace analysis of emerging virus, and thus has the potential to serve as a paradigm for monitoring of emerging infectious disease.


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