conductivity detection
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AAPS Open ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Deanna J. Nelson ◽  
G. Dean Marbury

AbstractIon chromatography (IC) has evolved into one of the most widely used separation techniques of analytical chemistry. Consequently, the number of users of this method is continuously growing. Analysts often assume that widely used guidelines for HPLC method validation in regulated environments routinely apply to IC. This manuscript provides an analysis of the potential shortcomings of traditional approaches to development and validation of IC methods using suppressed conductivity detection and a risk-based alternative approach to these activities. The goal of the alternative approach is a reduction in the risk of erroneous determinations of analytes when IC methods using suppressed conductivity detection are employed.


Author(s):  
Le Minh Dinh ◽  
Quoc Anh Hoang ◽  
Ngoc Mai Pham Thi ◽  
Anh Huong Nguyen Thi ◽  
◽  
...  

Food quality control has become much more important during the last decade and demanded the development of robust, efficient, sensitive, and cost-effective analytical techniques. Capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) is a powerful separation method based on the different migration time rate of components in the background electrolyte solution, and it is suitable for all charged ions. There is a large number of compound groups in food that can be determined by the CE-C4D method, such as amino acids, biogenic amines, fatty acids, food additives, sweeteners, and nutrients. This paper provides an overview of recent applications of the CE-C4D in food analysis over the last decade. General conclusions and future prospects of applicability of the CE-C4D method in food analysis are presented.


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