EVALUATION OF LIPID PROFILE AND THYROID HORMONE LEVELS IN PATIENTS WITH CHRONIC PANCREATITIS COMBINED WITH HYPOTHYROIDISM

With hypothyroidism (HТ) there is a change in homeostasis in tissues sensitive to thyroidhormones, which in its turn leads to a violation of fat metabolism. HT induces a significantincrease in lipid peroxidation and reduces the activity of antioxidant enzymes, oxidativestress, which is formed in HT, can play a key role in the progression of pancreaticdysfunction (PD).Purpose – to study the indicators of the lipid profile and the level of thyroid hormones inpatients with CP and CP, combined with HT.Material and methods 107 people were examined, including 29 patients with CP (group1), 30 patients with HT (group 2), 28 patients with CP on the associated with HT (group3), 20 almost healthy individuals (AHI) (group 4). The age of the examined patientsranged from 44 to 72 years, the main percentage (53%) was dominated by people ofworking age from 49 to 58 years (mean age - 54.26 ± 1.87). The gender distribution wascomparable across all groups. According to the local ethics committees for biomedicalresearch, guided by Ukrainian health legislation and the 2000 a. declaration of Helsinki,all patients and AHI surveyed gave written informed consent to participate in the study.All patients were hospitalized at the Chernivtsi Regional Clinical Hospital and theChernivtsi Regional Endocrinology Center.The results. According to the results of the study of the lipid profile in all groups of patientsthere were manifestations of dyslipidemia, but they were more pronounced in patientswith combined pathology: total cholesterol increased 36.04% (p <0.05) compared withAHI; 21.37% compared with the group of patients with CP and by 15.06% compared withthe group of patients with CP. The level of triglycerides increased in the group of patientswith CP, associated with HT in 2.2 times compared with AHI group, in comparison ofthe groups of the combined pathology with CP patients and with HT patients it is higher 34.51% and 9.4% (p <0, 05). Patients in all 3 groups had an increase in very low-densitylipoprotein cholesterol compared with AHI, with a tendency to increase in patients inwhom CP was combined with HT.Conclusion. The most pronounced signs of dyslipidemia were found in patients with CPcombined with HT, which confirms the close pathogenetic link between these nosologies- a marker of thyroid insufficiency (increased TSH levels, decreased T4), manifestationsof dyslipidemia, which is a predictor of pancreatic lesions. The study of comorbidity ofthese nosologies is a promising area of clinical gastroenterology and endocrinology. Theresults prove the need for more detailed and in-depth study of the clinical course andinteraction of these diseases, in order to optimize the therapeutic treatment regimens, thatwill allow to avoid the development of complications and disability.

Mental health legislation in Luxembourg, a small country in Western Europe

The article provides a brief overview of the legislation governing involuntary admissions to psychiatric hospitals in Luxembourg. The legislation was completely overhauled in 2009 and several human rights principles are enshrined into it. Emphasis is placed on voluntary, community-based treatment, and where compulsory treatment is required, it uses the least restrictive treatment option. Mentally ill offenders are dealt with through separate specialist legislation. Young people under the age of 18 are often detained using family law.

America's Wellness Consumerism

The purpose of the study is to investigate historical “wellness consumerism” and why it has continued to exist. Wellness consumerism is distinct from concepts like health consumerism in that it is not strictly related to or reinforced by the U.S. health care system. The opposite has tended to occur because of rampant online health misinformation. Present research does not unite public health, online health misinformation, and socioeconomic influences (e.g. the wellness movement and wellness economy) under a common framework nor does it examine them with a historical perspective. In addition, present research does not examine the relationship between online health misinformation and wellness trends. Medical journals, the history of the wellness movement, and oral history interviews from witnesses of the wellness movement were used to explore wellness consumerism’s impact on people and public health. A study was conducted on a random sample of Amazon dietary supplements to investigate the relationship between health misinformation and affiliation with wellness trends. The results provide strong evidence for an association between the two, suggesting that producers of the wellness economy may be likely to spread health misinformation. Wellness consumerism resulted from co-optation of wellness by producers and has sustained longevity because it fills a gap in healthcare demand and worsens existing distrust in it. Wellness consumerism promotes a cycle of health information sharing that has negative implications for public health. This study highlights health problems uniquely associated with wellness consumerism and sheds light on other possible future socioeconomic challenges to public health while providing a basis for further consumer protections or health legislation that may be discussed in U.S. policy circles

Tracking the outbreak: an optimized sequential adaptive strategy for Xylella fastidiosa delimiting surveys

The EU plant health legislation enforces the implementation of intensive surveillance programs for quarantine pests. After an outbreak, surveys are implemented to delimit the extent of the infested zone and to manage disease control. Surveillance in agricultural and natural environments can be enhanced by increasing the survey efforts. Budget constraints often limit inspection and sampling intensities, thus making it necessary to adapt and optimize surveillance strategies. A sequential adaptive delimiting survey involving a three-phase and a two-phase design with increasing spatial resolution was developed and implemented for the Xylella fastidiosa demarcated area in Alicante, Spain. Inspection and sampling intensities were optimized using simulation-based methods. Sampling intensity thresholds were evaluated by quantifying their effect on the estimation of X. fastidiosa incidence. This strategy made it possible to sequence inspection and sampling taking into account increasing spatial resolutions, and to adapt the inspection and sampling intensities according to the information obtained in the previous, coarser, spatial resolution. The proposed strategy was able to efficiently delimit the extent of Xylella fastidiosa, while improving on the efficiency and maintaining the efficacy of the official survey campaign. From a methodological perspective, our approach provides new insights into alternative delimiting designs and new reference sampling intensity values.

From Frontier to Border: The 1845 Health Code and the Structuring of Greece’s Quarantine System

How did health technologies influence border construction, identityformation and political developments in nineteenth-century Greece? The study focuses on the 1845 Health Code, which instituted a comprehensive system of coastal and inland lazarettos and health offices. It presents the development of the health border system prior to the enactment of the code and explains the timing of the enactment of that legislation.Compared to other important health legislation, the code had a long gestation as a result of the combined and often conflicting influences of five interrelated factors: commercial relations with the Ottoman Empire; the health preoccupations of Western European states; the significance of the plague; the cultural orientation of the Greek state towards “Western civilisation”; and the capacity of the Greek administration to exercise control over its territory. The code, a step towards the geographical and cultural reorientation of a former Ottoman province as a sovereign state, defines the slow passage from the empire’s frontiers to the state border system.

Knowledge, Attitudes and Practices of Health Legislation and Regulations by Dentists and Stomatologists in the Valencian Community: A KAP Analysis.

The authors have requested that this preprint be withdrawn due to a need to make corrections.

Analysis of the knowledge on Legal and Forensic Dentistry and Health Legislation and Regulations by Dentists and Stomatologists in the Valencian Community and its relationship with five background factors

The main objective of this study is to analyse the background and knowledge of Spanish dentists and stomatologists registered in Alicante, Castellón and Valencia, the three provinces that make up the Valencian Community, with regard to forensic dentistry and the current Spanish health legislation and regulations, and to try to quantify the relationship between level of training, specialisation, work experience, position and workplace, and degree of knowledge.An anonymous survey was designed and validated, consisting of thirty-three multiple-choice questions. The survey included questions regarding their professional background and key questions regarding current dental law, forensic science and expertise. Members' level of knowledge of legal and forensic dentistry, health legislation and regulations in the Valencian Community is moderate, with only 63% of the questions answered correctly. Neither their level of education nor work experience correlates significantly with their degree of knowledge. Dentists specialising in General and Aesthetics Dentistry were found to be more knowledgeable about ethical issues. Regarding the workplace, those working as university teachers tended to stand out from the other professionals in terms of legal and ethical knowledge whilst self-employed and employee dentists show a lower level of knowledge than the rest of the sample.The conclusions obtained from this study highlight the need for dentists to complete and update their knowledge of forensic science and current health legislation, as having proper knowledge is a means of avoiding possible legal problems, which not only means better legal protection for the dentist but is also a means of guaranteeing adequate patient care.