acid supplementation
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2023 ◽  
Vol 83 ◽  
A. Ayub ◽  
F. Rasool ◽  
N. Khan ◽  
S. N. Qaisrani ◽  
S. Parveen ◽  

Abstract Ninety days study was conducted in hapas installed in earthen ponds. Fish of an average initial weight (220g) were evenly distributed in triplicate groups within fifteen hapas. Five experimental diets labeled as T1 (25% CP and NRC recommended amino acid level) as control diet, T2 (with 2% low protein and 5% amino acid supplementation), T3 (with 2% low protein and 10% amino acid supplementation), T4 (with 4% low protein and 10% amino acid supplementation) and T5 (with 4% low protein and 20% amino acid supplementation) were prepared. Fish were fed with @3% of their body weight twice a day at 10.00 & 16:00 hour. Significantly higher percent weight gain (420.18 ± 66.84a) and specific growth rate (13499.33±1273.54a) along with improved feed conversion ratio (1.29 ± 0.09b) and hundred percent survivals were recorded during the trial. Furthermore proximate analysis of meat showed significant improvement in the crude protein level (81.77 ± 0.19a) served with diet containing 20% limiting amino acids mixture. Therefore, limiting amino acids can be a source of cost effective feed and use safely in L. rohita diet.

Lupus ◽  
2022 ◽  
pp. 096120332110679
Nina Ramessar ◽  
Abhilasha Borad ◽  
Naomi Schlesinger

Objective Many rheumatologists are inundated with questions about what “natural remedies” and “anti-autoimmune diets” exist for decreasing Systemic Lupus Erythematosus (SLE) disease activity. Over the last three decades, there has been an abundance of data from several different trials about omega-3 fatty acids sourced from fish oil, but the findings have been contradictory. This review seeks to present this data so that evidence-based recommendations can be given to patients, supporting the use of an adjuvant regimen with their present immunosuppression. Methods A literature search was conducted using the PubMed, Google Scholar, MEDLINE, and Scopus electronic databases to retrieve relevant articles for this review. Trials conducted on human subjects with SLE with full publications in English were included from 1 January 1980 to 1 April 2021. The impact of fish oil-derived omega-3 fatty acid supplementation on specific clinical features, the innate and adaptive immune response, biomarkers, and disease activity measures were assessed. The initial search yielded 7519 articles, but only 13 met our criteria and were eligible for this review. Results Data from thirteen articles were assessed. Ten trials assessed disease activity as an outcome, with eight trials demonstrating an improvement in patients in the omega-3 fatty acid group as assessed by a validated clinical tool or individual patient criteria. There was a significant improvement in Systemic Lupus Activity Measure-Revised (SLAM-R) scores at week 12 ( p = .009) and week 24 ( p < .001). Additionally, a reduction of urinary 8-isoprostane, a non-invasive marker of disease activity, was observed. There was no treatment benefit seen with respect to renal parameters such as serum creatinine or 24-hour urine protein; or systemic parameters such as C3, C4, or anti-double stranded DNA (anti-dsDNA) levels regardless of the dose of the omega-3 LUPUS fatty acids or duration of the trial. Conclusion While there is conflicting evidence about the benefits of omega-3 fatty acid supplementation on SLE disease activity, specific measures have demonstrated benefits. Current data show that there is a potential benefit on disease activity as demonstrated by SLAM-R, Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and British Isles Lupus Assessment Group (BILAG) scores and plasma membrane arachidonic acid composition and urinary 8-isoprostane levels, with minimal adverse events.

2022 ◽  
pp. 1-9
Yahya M. Hodeeb ◽  
Emad M. El-Rewiny ◽  
Abdullah M. Gaafar ◽  
Ahmed N. Zayed ◽  
Mohamed S. Hasan ◽  

2022 ◽  
Kavitha Krishnappa ◽  

Abstract Ageing is a complex biological process of all flora and fauna. It leads to a gradual reduction in the ability to maintain homeostasis under internal physiological and external environmental stresses, hence reducing the viability of individual's and increasing their vulnerability to diseases. The objective of this study was to investigate the alteration in the oxidant /antioxidant balance and hematology in four different age group of indigenous Tharparkar cattle and its amelioration by ascorbic acid. A total 24 female Tharparkar cattle were included and were categorized into 4 groups of six cows in each group. Animals below 1 year-age were kept in group I, between 1 to 8 year-age in group II, between 8-10 year-age in group III and above 10 year-age in group IV. The oxidant/antioxidant markers (LPO, SOD, GSH, GPX and catalase activity) and haematological panels (Hb, TEC, TLC, Platelet and DLC) were determined on day 0, before ascorbic acid supplementation, and on day 6, 12, 18 and 24 post ascorbic acid supplementation. In the present study LPO and SOD levels were significantly (P < 0.05) increased with the ageing. GSH and GPX activities significantly (P < 0.05) decreased with ageing in different age groups. Variations in hematological parameters were also observed with ageing in different age groups. The geriatric cattle (> 10 years) exhibited remarkable alteration in oxidative stress indices, and haematological panels when compared to other groups. Supplementation of ascorbic acid reduced the oxidative stress and improved hemoglobin, PCV, TEC and TLC levels. From the findings of this study, it can be inferred that administration of ascorbic acid is helpful in ameliorating altered oxidant/antioxidant balance and hematological parameters with ageing in various age groups of cattle.

2022 ◽  
Vol 137 ◽  
pp. 264-274
Sumeth Wongkiew ◽  
Chongrak Polprasert ◽  
Thammarat Koottatep ◽  
Tawan Limpiyakorn ◽  
K.C. Surendra ◽  

Biology ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 28
Xuhui Han ◽  
Bingqi Wang ◽  
Dongxu Jin ◽  
Kuang Liu ◽  
Hongjie Wang ◽  

Folic acid, one of the 13 essential vitamins, plays an important role in cardiovascular development. Mutations in folic acid synthesis gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with the occurrence of congenital heart disease. However, the mechanisms underlying the regulation of cardiac development by mthfr gene are poorly understood. Here, we exposed zebrafish embryos to excessive folate or folate metabolism inhibitors. Moreover, we established a knock-out mutant of mthfr gene in zebrafish by using CRISPR/Cas9. The zebrafish embryos of insufficient or excessive folic acid and mthfr−/− mutant all gave rise to early pericardial edema and cardiac defect at 3 days post fertilization (dpf). Furthermore, the folic acid treated embryos showed abnormal movement at 5 dpf. The expression levels of cardiac marker genes hand2, gata4, and nppa changed in the abnormality of folate metabolism embryos and mthfr−/− mutant, and there is evidence that they are related to the change of methylation level caused by the change of folate metabolism. In conclusion, our study provides a novel model for the in-depth study of MTHFR gene and folate metabolism. Furthermore, our results reveal that folic acid has a dose-dependent effect on early cardiac development. Precise dosage of folic acid supplementation is crucial for the embryonic development of organisms.

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