magnesium intake
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2021 ◽  
Vol 8 ◽  
Author(s):  
Weichao Huang ◽  
Xiaoman Ma ◽  
Hualiang Liang ◽  
Haojia Li ◽  
Jiayu Chen ◽  
...  

Introduction: Circulating vitamin D concentrations have been associated with the risk of type 2 diabetes (T2D). Magnesium has also been reported to be associated with lower T2D risk. Besides, magnesium is an essential cofactor for vitamin D activation. However, the effect of dietary magnesium intake on the association between vitamin D and the risk of T2D has not been studied comprehensively. Therefore, we designed this cross-sectional study to assess the effect modification of magnesium intake on the association between vitamin D and risk of T2D.Research Design and Methods: The present study analyzed data from the National Health and Nutrition Examination Survey (NHANES) continuously from 2007 to 2014, involving 10,249 participants. By having stratified participants based on magnesium intake category (low magnesium intake <267 mg/day; high magnesium intake: ≥267 mg/day), we further evaluated the difference (interaction test) between the relationship of vitamin D with the risk of T2D among low magnesium intake participants and high magnesium intake participants using weighted multivariable logistic regression.Results: In this cross-sectional study, the association of serum vitamin D with the incidence of T2D appeared to differ between the low magnesium intake group and the high magnesium intake group (OR: 0.968, 95%Cl: 0.919–1.02 vs. OR: 0.925, 95%Cl: 0.883–0.97). Furthermore, there was evidence of interaction between vitamin D levels and magnesium intake on decreasing the incidence of T2D (p-value for interaction = 0.001).Conclusions: The results of our study indicated that magnesium intake might affect the association of serum vitamin D with the risk of T2D. Such a finding requires further randomized controlled trials to provide more evidence.


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4141
Author(s):  
Helena J. Bentil ◽  
Alyssa M. Abreu ◽  
Seth Adu-Afarwuah ◽  
Joseph S. Rossi ◽  
Alison Tovar ◽  
...  

Low magnesium intake has been shown to be associated with an increased risk of type 2 diabetes mellitus (T2DM) in several studies conducted in high-income countries. However, very few studies have been performed in Africa, where many countries have a growing rate of T2DM. We conducted a pilot cross-sectional study among 63 women in Ghana to investigate the association between magnesium intake and glycemic markers. We assessed dietary magnesium using a food frequency questionnaire and glycemic markers using fasting blood glucose and glycated hemoglobin A1c (HbA1c). Our findings showed that the mean magnesium intake was 200 ± 116 mg/day. The prevalence of T2DM was 5% by measuring fasting blood glucose and 8% by measuring HbA1c. Unadjusted linear regression models revealed that higher magnesium intake significantly predicted higher fasting blood glucose levels (β = 0.31; 95% CI: 0.07, 0.55; p = 0.01) and HbA1c levels (β = 0.26; 95% CI: 0.01, 0.51; p = 0.04). In adjusted analyses, magnesium intake was no longer significantly associated with either fasting blood glucose levels (β = 0.22; 95% CI: −0.03, 0.46; p = 0.08) or HbA1c levels (β = 0.15; 95% CI: −0.08, 0.39; p = 0.20). In conclusion, our study did not show a significant association between magnesium intake and glycemic markers in women of reproductive age in Ghana. The results of this study need to be further substantiated because this was the first study to examine magnesium intake and glycemic markers in this population in Africa.


2021 ◽  
pp. jim-2021-001841
Author(s):  
Fernando Guerrero-Romero ◽  
Gerardo Morales-Gurrola ◽  
Lucía Preza-Rodríguez ◽  
Alejandra Gómez-Barrientos ◽  
Ana I Olivas-Martínez ◽  
...  

Although magnesium intake is inversely associated with the risk of metabolic abnormalities, whether magnesium intake plays a role on metabolically healthy obese (MHO) phenotype has not been explored. Therefore, the purpose of this study was to determine whether the magnesium intake is associated with the MHO phenotype. Apparently, healthy women and men aged 20–65 years with obesity were enrolled in a cross-sectional study. Subjects were allocated into MHO (n=124) and metabolically unhealthy obese (MUO) (n=123) groups. MHO phenotype was defined by abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm in women) and none, or not more than one of the following risk factors: triglyceride levels ≥150 mg/dL; high-density lipoprotein cholesterol (HDL-C) levels <40 mg/dL in men and <50 mg/dL in women; fasting glucose ≥100 mg/dL; and systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg. The MUO individuals were characterized by abdominal obesity and the presence of two or more of the aforementioned criteria. The proportion of individuals with high blood pressure (40.7% vs 5.6%, p<0.001), hyperglycemia (69.1% vs 16.9%, p<0.001), hypertriglyceridemia (84.6% vs 36.3%, p<0.001), and low HDL-C (51.2% vs 12.9%, p<0.001) was significantly higher in the MUO individuals as compared with individuals in the MHO group. The logistic regression analysis adjusted by sex and age showed that dietary magnesium intake is significantly associated with the MHO phenotype (OR=1.17; 95% CI 1.07 to 1.25, p=0.005). Our results show that magnesium intake is significantly associated with the MHO phenotype.


2021 ◽  
pp. 1-33
Author(s):  
T. Madeira ◽  
M. Severo ◽  
D. Correia ◽  
C. Lopes ◽  
J. Gorjão Clara

Abstract Malnutrition (synonym: undernutrition) is prevalent among older adults, which may be partly related to changes in dietary intake, but evidence on the link between malnutrition and diet is scarce. The aims of this study were to estimate the association between energy/nutrients intake and malnutrition, and to characterise nutritional inadequacy in institutionalised and non-institutionalised older adults. A national survey was conducted including a Portuguese representative sample of nursing home (NH) residents (n=563) and community-dwellers (n=837) aged ≥ 65. Data included sociodemographic characteristics, self-reported health, loneliness feelings, nutritional status (Mini Nutritional Assessment®), and dietary intake (two non-consecutive 24-hour recalls). A higher energy intake was associated with lower odds of malnutrition risk (being ‘at risk of malnutrition’ or ‘malnourished’) in both settings, but only significant among NH residents after adjusting for confounders (NH: odds ratio [OR]=0.66, 95% confidence interval [CI] 0.50, 0.86; community: OR=0.64, 95% CI 0.37, 1.10). The intake of carbohydrates, fat, fibre, vitamin C, sodium, and potassium was inversely associated with malnutrition risk in NH residents; as well as protein, fat, vitamin B6, folates, sodium, potassium, calcium, and magnesium intake in community-dwellers. After additional adjustment for total energy only sodium and magnesium intake of community-dwellers remained significantly associated. The prevalence of inadequate nutrient intake was generally higher for the malnutrition risk group, which was particularly evident among community-dwellers. The effect of dietary intake on nutritional status seems more dependent on total energy and carbohydrates intake in institutionalised elders, whereas among community-dwellers protein and some micronutrients appear to have a greater impact.


2021 ◽  
Author(s):  
Weichao Huang ◽  
Xiaoman Ma ◽  
Yue Chen ◽  
Jiayi Zheng ◽  
Haojia Li ◽  
...  

Abstract IntroductionAlthough the association between blood pressure and vitamin D has been well studied, the effects of dietary magnesium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary magnesium intake on the association between vitamin D and blood pressure.Research design and methodsThe present study analyzed data from the continuous NHANES 2007-2014. We included 8799 participants aged 20 years or older. Multivariable linear regression was performed to assess the association between vitamin D and systolic blood pressure (SBP), diastolic blood pressure (DBP). Dietary magnesium intake was stratified by low magnesium intake (<299mg/d), high magnesium intake (>=299mg/d). Effect modification by dietary magnesium intake was assessed through interaction tests between vitamin D and SBP in the multivariable linear regression.ResultsIn this cross-sectional study, we found vitamin D was negatively related to SBP, but not to DBP. The relationship between vitamin D and SBP was different in the low and high magnesium intake group (β: -0.18 95%Cl: -0.35-0 vs β: -0.3 95%Cl: -0.51- -0.1). Furthermore, magnesium intake significantly modified the negative relationship between vitamin D and SBP (P value for interaction: 0.026).ConclusionOur research showed that magnesium and vitamin D have an interactive effect in reducing SBP, which may have great importance for clinical medication.


Author(s):  
Emma A. Vermeulen ◽  
Hanne B. T. de Jong ◽  
Alexander G. A. Blomjous ◽  
Coby Eelderink ◽  
Tiny Hoekstra ◽  
...  

Abstract Purpose Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the association between dietary magnesium intake and several measures of vascular structure and function in a prospective cohort. Methods We included 789 participants who participated in the vascular screening sub-cohort of the Hoorn Study, a population-based, prospective cohort study. Baseline dietary magnesium intake was estimated with a validated food frequency questionnaire and categorised in energy-adjusted magnesium intake tertiles. Several measurements of vascular structure and function were performed at baseline and most measurements were repeated after 8 years of follow-up (n = 432). Multivariable linear and logistic regression was performed to study the cross-sectional and longitudinal associations of magnesium intake and intima-media thickness (IMT), augmentation index (Aix), pulse wave velocity (PWV), flow-mediated dilatation (FMD), and peripheral arterial disease (PAD). Results Mean absolute magnesium intake was 328 ± 83 mg/day and prior CVD and DM2 was present in 55 and 41% of the participants, respectively. Multivariable regression analyses did not demonstrate associations between magnesium intake and any of the vascular outcomes. Participants in the highest compared to the lowest magnesium intake tertile demonstrated in fully adjusted cross-sectional analyses a PWV of −0.21 m/s (95% confidence interval −1.95, 1.52), a FMD of −0.03% (−0.89, 0.83) and in longitudinal analyses an IMT of 0.01 mm (−0.03, 0.06), an Aix of 0.70% (−1.69, 3.07) and an odds ratio of 0.84 (0.23, 3.11) for PAD Conclusion We did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses.


Author(s):  
Shahrzad Shokati ◽  
Zahra Kavian ◽  
Mansour Shahraki ◽  
Mona Afshari

Background: Depression, as the second leading cause of dysfunction, is one of the most common mental health disorders. Given that micronutrients have always played a significant role in all physical and psychological aspects of individuals. This study was conducted to investigate the relationship of dietary intake of Selenium, Magnesium, Zinc, and anthropometric profiles with depression in female students at Zahedan University of Medical Science, Zahedan, Iran. Methods: In this cross-sectional study, 200 female medical students of Zahedan University of Medical Sciences participated. The amount of dietary intake of Selenium, Magnesium, and Zinc were measured by Food Frequency Questionnaire (FFQ). For determining the depression score, Beck anxiety questionnaire was administered. To analyze the data, SPSS 22 software was used. Results: The mean of age, body mass index, waist-to hip ratio and waist-to-height ratio were 23.41 ± 2.26 years, 23.54 ± 4.49 kg/m2, 0.85 ± 0.08, and 0.59±0.10, respectively. The mean daily intake of Magnesium, Zinc, and Selenium were 196.37 ± 42.08 mg, 7.38 ± 3.41 mg, and 106.52 ± 31.69 mg, respectively. The mean of depression score was 31.21±10.58. Zinc and Magnesium intake had a significantly strong inverse relationship with depression score and anthropometric indices. Conclusions: The findings showed that Zinc and Magnesium intake as well as anthropometric indices had a significant inverse relationship with depression score. However, the association between Selenium intake and depression score was not significant.


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