Different Metabolomic and Proteomic Profiles of Cerebrospinal Fluid in Ventricular and Lumbar Compartments in Relation to Leptomeningeal Metastases

The different molecular profiles of cerebrospinal fluid (CSF) between ventricular and lumbar compartments remain elusive, especially in the context of leptomeningeal metastasis (LM), which affects CSF flow. We evaluated CSF metabolomic and proteomic profiles based on the compartments and the diagnosis of spinal LM, proved by MRI from 20 paired ventricular and lumbar CSF samples of LM patients, including 12 spinal LM (+) samples. In metabolome analysis, 9512 low-mass ions (LMIs) were identified—7 LMIs were abundant in all lumbar versus paired ventricular CSF samples, and 3 LMIs were significantly abundant in all ventricular CSF. In comparisons between spinal LM (+) CSF and LM (−) CSF, 105 LMIs were discriminative for spinal LM (+) CSF. In proteome analysis, a total of 1536 proteins were measured. A total of 18 proteins, including complement C3, were more highly expressed in all lumbar CSF, compared with paired ventricular CSF, while 82 proteins, including coagulation factor V, were higher in the ventricular CSF. Of 37 discriminative proteins, including uteroglobin and complement component C8 gamma chain, 4 were higher in all spinal LM (+) CSF versus spinal LM (−) CSF. We further evaluated metabolic pathways associated with these discriminative proteins using the Gene Ontology database. We found that 16/17 spinal LM (+) pathways, including complement activation, were associated with lumbar discriminative proteins, whereas only 2 pathways were associated with ventricular-discriminative proteins. In conclusion, we determined that metabolite and protein profiles differed between paired lumbar and ventricular CSF samples. The protein profiles of spinal LM (+) CSF showed more similarity with the lumbar CSF than the ventricular CSF. Thus, we suggest that CSF LMIs and proteins could reflect LM disease activity and that LM-associated differences in CSF are more likely to be present in the lumbar compartment.

A massive variable flavour number scheme for the Drell-Yan process

The prediction of differential cross-sections in hadron-hadron scattering processes is typically performed in a scheme where the heavy-flavour quarks (c, b, tc,b,t) are treated either as massless or massive partons. In this work, a method to describe the production of colour-singlet processes which combines these two approaches is presented. The core idea is that the contribution from power corrections involving the heavy-quark mass can be numerically isolated from the rest of the massive computation. These power corrections can then be combined with a massless computation (where they are absent), enabling the construction of differential cross-section predictions in a massive variable flavour number scheme. As an example, the procedure is applied to the low-mass Drell-Yan process within the LHCb fiducial region, where predictions for the rapidity and transverse-momentum distributions of the lepton pair are provided. To validate the procedure, it is shown how the n_fnf-dependent coefficient of a massless computation can be recovered from the massless limit of the massive one. This feature is also used to differentially extract the massless N^3LON3LO coefficient of the Drell-Yan process in the gluon-fusion channel.

Investigating the Baryon Cycle in Interacting Dwarfs with the Very Large Array and Pan-STARRS

We present resolved H i synthesis maps from the Very Large Array of three interacting dwarf systems: the NGC 3664 dwarf pair, the NGC 3264 dwarf pair, and the UGC 4638 dwarf triplet. All three dwarf systems are captured at various stages of interaction and span a range of environments. We detect clear hallmarks of tidal interactions through the presence of H i bridges and diffuse H i extensions that surround the dwarfs. We overlay the H i data on Pan-STARRS r-band images and find further evidence of tidal interactions through coincident distorted H i and tidal stellar features in NGC 3264 and UGC 4638, and an unwound spiral arm pointing toward its smaller companion in NGC 3264. In UGC 4638, both the gas and diffuse stars are extended to similar radii east of the primary, which could indicate that the smaller dwarf in the system has already completed one pass through the primary. We additionally find that our three systems, and those from the Local Volume TiNy Titans survey, are not H i deficient and thus the interaction has not resulted in a loss of gas from the systems. A comparison with noninteracting dwarf galaxies shows that the interactions have a significant impact on the kinematics of the systems. Our new resolved H i kinematics, combined with detailed stellar and H i morphologies, provide crucial constraints for future dynamical modeling of hierarchical mergers and the baryon cycle at the low-mass scale.

One Soft Step: Bio-Inspired Artificial Muscle Mechanisms for Space Applications

Soft robots, devices with deformable bodies and powered by soft actuators, may fill a hitherto unexplored niche in outer space. All space-bound payloads are heavily limited in terms of mass and volume, due to the cost of launch and the size of spacecraft. Being constructed from stretchable materials allows many possibilities for compacting soft robots for launch and later deploying into a much larger volume, through folding, rolling, and inflation. This morphability can also be beneficial for adapting to operation in different environments, providing versatility, and robustness. To be truly soft, a robot must be powered by soft actuators. Dielectric elastomer transducers (DETs) offer many advantages as artificial muscles. They are lightweight, have a high work density, and are capable of artificial proprioception. Taking inspiration from nature, in particular the starfish podia, we present here bio-inspired inflatable DET actuators powering low-mass robots capable of performing complex motion that can be compacted to a fraction of their operating size.

A Significant Detection of X-ray Polarization in Sco X-1 with PolarLight and Constraints on the Corona Geometry

We report the detection of X-ray polarization in the neutron-star low-mass X-ray binary Scorpius (Sco) X-1 with PolarLight. The result is energy-dependent, with a nondetection in 3–4 keV but a 4σ detection in 4–8 keV; it is also flux-dependent in the 4–8 keV band, with a nondetection when the source displays low fluxes but a 5σ detection during high fluxes, in which case we obtain a polarization fraction of 0.043 ± 0.008 and a polarization angle of 52.°6 ± 5.°4. This confirms a previous marginal detection with OSO-8 in the 1970s and marks Sco X-1 as the second astrophysical source with a significant polarization measurement in the keV band. The measured polarization angle is in line with the jet orientation of the source on the sky plane (54°), which is supposedly the symmetry axis of the system. Combining previous spectral analysis, our measurements suggest that an optically thin corona is located in the transition layer under the highest accretion rates, and disfavor the extended accretion disk corona model.

The Fragmented Glueball: A Personal View

A coupled-channel analysis has been performed to identify the spectrum of scalar mesons. The data include BESIII data on radiative J/ψ decays into π0π0, KS KS, ηη, and ωϕ, 15 Dalitz plots from ¯N annihilation at rest at LEAR, the CERN-Munich multipoles for ππ elastic scattering, the S-wave from BNL data on ππ scattering into KS KS, from GAMS data on ππ π0π0; ηη, and ηη', and NA48/2 data on low-mass ππ interactions from K± → ππe±v decays. The analysis reveals the existence of ten scalar isoscalar resonances. The resonances can be grouped into two classes: resonances with a large SU(3) singlet component and those with a large octet component. The production of isoscalar resonances with a large octet component should be suppressed in radiative J/ψ decays. However, in a limited mass range centered at 1900MeV, these mesons are produced abundantly. Mainly-singlet scalar resonances are produced over the full mass range but with larger intensity at 1900MeV. The total scalar isoscalar yield in radiative decays into scalar mesons shows a clear peak which is interpreted as the scalar glueball of lowest mass.

Hybrid stars from a constrained equation of state

We determine, within a meta-model, the properties of the nuclear matter equation of state (EoS) that allow for a phase transition to deconfinement matter. It is shown that the properties that define the isoscalar channel are the ones that are affected, in particular, a phase transition implies much larger values of the skewness and kurtosis. The effect of multi-quark interaction channels in the description of the quark phase in hybrid stars is also studied. NS properties, such as the mass and radius of the quark core, show an interplay dependence between the 8-quark vector and the 4-quark isovector-vector interactions. We show that low mass NS, M ~ 1.4M⊙, may already contain a quark core, and satisfy all existing NS observational constraints. We discuss the strangeness content of the quark core and its influence on the speed of sound.