flight response
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Ecotoxicology ◽  
2022 ◽  
Author(s):  
Palesa Andile Adrena Tsotesti ◽  
Simangele Sandra Mazibuko ◽  
Ngitheni Winnie-Kate Nyoka ◽  
Sanele Michelle Mnkandla ◽  
Tanya Fouché ◽  
...  

2021 ◽  
Author(s):  
James H Kryklywy ◽  
Amy Lu ◽  
Kevin H Roberts ◽  
Matt Rowan ◽  
Rebecca Todd

In times of stress or danger, the autonomic nervous system (ANS) signals the fight or flight response. A canonical function of ANS activity is to globally mobilize metabolic resources, preparing the organism to respond to threat. Yet a body of research has demonstrated that, rather than displaying a homogenous pattern across the body, autonomic responses to arousing events - as measured through changes in electrodermal activity (EDA) - can differ between right and left body locations. Surprisingly, the metabolic function of such ANS asymmetry has not been investigated. In the current study, we investigated whether asymmetric autonomic responses could be induced through limb-specific aversive stimulation. Participants were given mild electric stimulation to either the left or right arm while EDA was monitored bilaterally. Across participants, a strong ipsilateral EDA response bias was observed, with increased EDA response in the hand adjacent to the stimulation. This effect was observable in over 50% of individual subjects. These results demonstrate that autonomic output is more complex than canonical interpretations suggest. We suggest that, in stressful situations, autonomic outputs can prepare either the whole-body fight or flight response, or a simply a limb-localized flick, which can effectively neutralize the threat while minimizing global resource consumption. These findings provide insight into the evolutionary pathway of neural systems processing general arousal by linking observed asymmetry in the peripheral arousal response to a historical leveraging of neural structures organized to mediate responses to localized threat.


2021 ◽  
Author(s):  
Mary S Kim ◽  
Oliver Monfredi ◽  
Larissa A Maltseva ◽  
Edward G Lakatta ◽  
Victor A Maltsev

The heartbeat is initiated by pacemaker cells residing in the sinoatrial node (SAN). SAN cells generate spontaneous action potentials (APs), i.e. normal automaticity. The sympathetic nervous system increases heart rate commensurate with blood supply and cardiac output demand, known as the fight-or-flight response, via stimulation of SAN β-adrenergic receptors (βAR). It is classically believed that all cells increase their spontaneous AP firing rate in a similar fashion. In the present study we measured βAR responses among 166 single SAN cells isolated from 33 guinea pig hearts. However, the responses substantially varied. In each cell changes in AP cycle length in response to βAR stimulation highly correlated (R2=0.97) with the AP cycle lengths before stimulation. While, as expected, on average the cells increased their pacemaker rate, greater responses were observed in cells with slower basal rates, and vice versa, cells with higher basal rates showed smaller responses, no responses, or even negative responses, i.e. their rate decreased. Thus, βAR stimulation synchronizes operation of the cell population towards a higher average rate, rather than uniformly shifting the rate in each cell, creating a new paradigm of fight-or-flight response among individual pacemaker SAN cells.


2021 ◽  
pp. 088626052110163
Author(s):  
Bella Klebanov ◽  
Carmit Katz

The peritraumatic response of children during incidents of child sexual abuse (CSA) is a neglected construct in the literature. Despite the widespread use of the fight-flight-freeze model, recent studies have shown that in the unique context of child abuse, additional peritraumatic responses could be relevant. The current mixed-methods study examined children’s peritraumatic responses to CSA. The sample consisted of 249 forensic interviews with children aged from 4 to 13 years. An initial qualitative analysis resulted in identifying various ways in which the children responded to the abuse, the children’s decision-making around these responses, as well their perceptions of their response. This analysis was followed by quantitative analyses, which explored the frequency of these peritraumatic responses and their correlation with the characteristics of the children and abuse. Six peritraumatic response categories were identified, the most common being fight, flight, and fear. Only ethnoreligious identity was significantly correlated with the fight-or-flight response, with a significantly lower frequency among Muslim and ultra-Orthodox Jewish children. Frequency of abuse and perpetrator familiarity were correlated with the frequency of the fight-or-flight response, indicating that the latter was less relevant in reoccurring incidents of abuse and with perpetrators who were family members. The findings promote the conceptualization of children’s peritraumatic responses during incidents of abuse and the realization of the crucial role of children’s ecological systems in their peritraumatic responses to incidents of abuse.


HORMONES ◽  
2021 ◽  
Author(s):  
Giampaolo Papi ◽  
Valentina Cuomo ◽  
Enrico Tedeschini ◽  
Rosa Maria Paragliola ◽  
Salvatore Maria Corsello ◽  
...  

Author(s):  
David Anthony Pittaway

The Covid-19 pandemic accelerated the global trend towards spending increasing amounts of time online. I explore some of the potential negative consequences of lockdown-induced increases in time spent online, and I argue that the stressful context of the pandemic and lockdowns is exacerbated by being online beyond that which is required for essential purposes. Time spent online may increase stress levels by perpetuating the sympathetic nervous system's fight-or-flight response, draining a person’s energy and diminishing one’s ability to deal with illness. I frame the situation as one in which the pandemic context, combined with a mandatory need to be online more, forces many people into what Daniel Kahneman calls “System 1 thinking”, or “fast thinking”. I argue that digital hygiene requires the suspension of System 1 thinking, and that “philosophical perception” resonates with potential remedies in this regard.


Behaviour ◽  
2020 ◽  
Vol 157 (6) ◽  
pp. 515-539
Author(s):  
Riva J. Riley ◽  
Thomas P. Roe ◽  
Elizabeth R. Gillie ◽  
Andrea Manica

Abstract Many social animals acquire social behaviours during development, and social experience during development can be vital for acquiring necessary social behaviours in adulthood. We investigated the development of a distinctive tactile interaction behaviour in Bronze Cory catfish, in which adults interact with one another tactilely during foraging and during group responses to threats. We found that larvae respond to applied tactile stimulation with a flight response significantly less often as larvae matured. This habituation to tactile stimulation is consistent with developing appropriate adult social behaviour. We also found that social exposure affects the larval response to tactile interactions with conspecifics, and that isolation in early life leads to a greater likelihood of responding to tactile interactions with conspecifics with a flight response. This suggests that social exposure is important for developing social tactile interaction behaviour and underscores the particular importance of early experience in social development.


2020 ◽  
Author(s):  
Xue Luo ◽  
Danrui Cai ◽  
Kejiong Shen ◽  
Qinqin Deng ◽  
Xinlan Lei ◽  
...  

AbstractThe looming stimulus-evoked flight response is an experimental paradigm for studying innate defensive behaviors. However, how the visual looming stimulus is transmitted from the retina to the brain remains poorly understood. Here, we report that superior colliculus (SC)-projecting RGCs transmit the looming signal from the retina to the brain to mediate the looming-evoked flight behavior by releasing GABA. In the mouse retina, GABAergic RGCs are capable of projecting to many brain areas, including the SC. Superior colliculus (SC)-projecting GABAergic RGCs (spgRGCs) are mono-synaptically connected to the parvalbumin-positive SC neurons known to be required for the looming-evoked flight response. Optogenetic activation of spgRGCs triggers GABA-mediated inhibition in SC neurons. The ablation or silence of spgRGCs compromises looming-evoked flight response but not image-forming functions. Therefore, this study shows that spgRGCs control the looming-evoked flight response by regulating SC neurons via GABA, providing novel insight into the regulation of innate defensive behaviors.


2020 ◽  
Vol 21 (6) ◽  
pp. 1946
Author(s):  
Antonio M. G. de Diego ◽  
Diana Ortega-Cruz ◽  
Antonio G. García

Synaptic disruption and altered neurotransmitter release occurs in the brains of patients and in murine models of neurodegenerative diseases (NDDs). During the last few years, evidence has accumulated suggesting that the sympathoadrenal axis is also affected as disease progresses. Here, we review a few studies done in adrenal medullary chromaffin cells (CCs), that are considered as the amplifying arm of the sympathetic nervous system; the sudden fast exocytotic release of their catecholamines—stored in noradrenergic and adrenergic cells—plays a fundamental role in the stress fight-or-flight response. Bulk exocytosis and the fine kinetics of single-vesicle exocytotic events have been studied in mouse models carrying a mutation linked to NDDs. For instance, in R6/1 mouse models of Huntington’s disease (HD), mutated huntingtin is overexpressed in CCs; this causes decreased quantal secretion, smaller quantal size and faster kinetics of the exocytotic fusion pore, pore expansion, and closure. This was accompanied by decreased sodium current, decreased acetylcholine-evoked action potentials, and attenuated [Ca2+]c transients with faster Ca2+ clearance. In the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS), CCs exhibited secretory single-vesicle spikes with a slower release rate but higher exocytosis. Finally, in the APP/PS1 mouse model of Alzheimer’s disease (AD), the stabilization, expansion, and closure of the fusion pore was faster, but the secretion was attenuated. Additionally, α-synuclein that is associated with Parkinson’s disease (PD) decreases exocytosis and promotes fusion pore dilation in adrenal CCs. Furthermore, Huntington-associated protein 1 (HAP1) interacts with the huntingtin that, when mutated, causes Huntington’s disease (HD); HAP1 reduces full fusion exocytosis by affecting vesicle docking and controlling fusion pore stabilization. The alterations described here are consistent with the hypothesis that central alterations undergone in various NDDs are also manifested at the peripheral sympathoadrenal axis to impair the stress fight-or-flight response in patients suffering from those diseases. Such alterations may occur: (i) primarily by the expression of mutated disease proteins in CCs; (ii) secondarily to stress adaptation imposed by disease progression and the limitations of patient autonomy.


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