arsenic poisoning
Recently Published Documents


TOTAL DOCUMENTS

381
(FIVE YEARS 42)

H-INDEX

36
(FIVE YEARS 4)

2022 ◽  
Vol 2022 ◽  
pp. 1-16
Author(s):  
Qibing Zeng ◽  
Sufei Du ◽  
Yuyan Xu ◽  
Fan Yang ◽  
Liping Wu ◽  
...  

Chronic exposure to inorganic arsenic is a major environmental public health issue worldwide affecting more than 220 million of people. Previous studies have shown the correlation between arsenic poisoning and cellular senescence; however, knowledge regarding the mechanism and effective prevention measures has not been fully studied. First, the associations among the ERK/CEBPB signaling pathway, oxidative stress, and arsenic-induced skin cell senescence were confirmed using the HaCaT cell model. In the arsenic-exposed group, the relative mRNA and protein expressions of ERK/CEBPB signaling pathway indicators (ERK1, ERK2, and CEBPB), cell cycle-related genes (p21, p16INK4a), and the secretion of SASP (IL-1α, IL-6, IL-8, TGF-β1, MMP-1, MMP-3, EGF, and VEGF) and the lipid peroxidation product (MDA) were significantly increased in cells ( P < 0.05 ), while the activity of antioxidant enzyme (SOD, GSH-Px, and CAT) was significantly decreased ( P < 0.05 ), and an increased number of cells accumulated in the G1 phase ( P < 0.05 ). Further Kaji-ichigoside F1 intervention experiments showed that compared to that in the arsenic-exposed group, the expression level of the activity of antioxidant enzyme was significantly increased in the Kaji-ichigoside F1 intervention group ( P < 0.05 ), but the indicators of ERK/CEBPB signaling pathway, cell cycle-related genes, and SASP were significantly decreased ( P < 0.05 ), and the cell cycle arrest relieved to a certain extent ( P < 0.05 ). Our study provides some limited evidence that the ERK/CEBPB signaling pathway is involved in low-dose arsenic-induced skin cell senescence, through regulating oxidative stress. The second major finding was that Kaji-ichigoside F1 can downregulate the ERK/CEBPB signaling pathway and regulate the balance between oxidation and antioxidation, alleviating arsenic-induced skin cell senescence. This study provides experimental evidence for further understanding of Kaji-ichigoside F1, a natural medicinal plant that may be more effective in preventing and controlling arsenic poisoning.


2021 ◽  
Vol 16 (3) ◽  
pp. 398-400
Author(s):  
Alina EPURE ◽  
◽  
Dan Mircea CHEȚA ◽  
◽  

Exposure to arsenic is common, but unconscious, inducing major imbalances especially in the digestive tract, lungs, skin. Contamination is achieved by exposure to arsenic in the air, soil, groundwater, food. It is noted the use of arsenic in pesticides, herbicides, paints, wood preservatives, drinking water, various foods with a wide range of consumption (seafood, rice – including rice milk, rice bran, rice cereals, rice syrup rice, rice crackers). The diagnosis of arsenic poisoning is an important step in establishing the diet and detoxification treatment, focusing on the cause, not the symptoms. We present the case of a 45-year-old patient with symptoms manifested in the digestive tract for 4 years: abdominal bloating, cramps, vomiting, weekly episodes of acute diarrhea. During these period the patient received multiple treatments depending on the symptoms, without a significant improvement, without performing specific investigations of arsenic poisoning. The personalized diet and treatment plan, used in the case of this patient, for a period of 4 months was distinguished by a total solution of the manifestations presented in the anamnesis stage.


2021 ◽  
Vol 42 (5) ◽  
Author(s):  
Huiling Li

Clinimetallomics is proposed as a branch of metallomics that focuses on the study of the metallome in clinical samples of urine, blood, and tissues. As the clinical diagnosis of arsenic poisoning is mainly based on the concentration of total arsenic in urine, the toxicity of arsenic varies greatly in different speciation. Analysis of arsenic speciation with excessive total arsenic in urine can provide a basis for precise treatment. It can also be used to understand the fate of arsenic in the body of patients with arsenic poisoning after treatment with sodium dimercaptopropane sulfonate. In this study, a HPLC-ICP-MS method was established for the determination of arsenic species in urine samples from patients diagnosed with arsenism. Use the established method to detect urine samples, which can be directly assayed after simple sample dilution with 20 mmol/L EDTA-2Na. With the concentration of arsenic speciation in the range of 1.0~100.0 ng/mL, the linear correlation coefficient was higher than 0.99996. The recoveries were between 92.4% and 109.0%. The precision of the concentration and retention time (n = 3) were less than 3.0% and 0.3%, respectively, and the detection limit was between 1.42 ng/mL and 1.86 ng/mL. This method can be applied to arsenic speciation in the urine of healthy people, in patients treated for arsenic poisoning, and in patients diagnosed with arsenism.


2021 ◽  
Vol XVIII (1) ◽  
pp. 204-204
Author(s):  
Ivan D. Baklushinskiy

The author cites six stories of patients with chronic paralysis of neuritic origin, where previously conventional treatment was used, but no recent result. The etiology of the cases used by the author is very diverse: arsenic poisoning, alcohol abuse, diphtheria, etc.


Author(s):  
Pham Thi Thanh Tam ◽  
Phan Viet Hai ◽  
Nguyen Thi Nga ◽  
Duong Dinh Cua ◽  
Nguyen Thi Mai

Arsenic is a poisoning metallic element, in which trivalent inorganic arsenic compounds are considered unique. Children can be exposed from arsenic containing water, food and folk remedies with unclear ingredients [1]. The main toxic mechanism of As3+ is inhibition of the pyruvate dehydrogenase (PDH) complex, which leads to decrease in acetyl-CoA production, decrease in cellular respiration and free oxygen radical (0-) and hydrogen peroxide (H202) are born, which make cytotoxic. Arsenic poisoning causes damage to multiple organs: keratosis of the skin, nail and squamous cell cancer, neuropathy, repolarization of the myocardium, liver damage and subsequent sequelaes [1], [2]. Arsenic poisoning has no specific symptoms, so it is easy to overlook, especially in children [2]. The epidemiological exploitation and history of poisoning drugs are very important to avoid missing arsenic poisoning. We report a case of successfully treated arsenic poisoning at the Vietnam National Children’s Hospital.


2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Victoria K. Mwaeni ◽  
James N. Nyariki ◽  
Ngalla Jillani ◽  
George Omwenga ◽  
Mathew Ngugi ◽  
...  

Abstract Background Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). As a pharmacological intervention, DMSA is unable to chelate arsenic molecules from intracellular spaces. The consequence is continued toxicity and cell damage in the presence of DMSA. A two-pronged approach that removes extracellular arsenic, while protecting from the intracellular arsenic would provide a better pharmacotherapeutic outcome. In this study, Coenzyme Q10 (CoQ10), which has been shown to protect from intracellular organic arsenic, was administered separately or with DMSA; following oral exposure to sodium meta-arsenite (NaAsO2) – a very toxic trivalent form of inorganic arsenic. The aim was to determine if CoQ10 alone or when co-administered with DMSA would nullify arsenite-induced toxicity in mice. Methods Group one represented the control; the second group was treated with NaAsO2 (15 mg/kg) daily for 30 days, the third, fourth and fifth groups of mice were given NaAsO2 and treated with 200 mg/kg CoQ10 (30 days) and 50 mg/kg DMSA (5 days) either alone or in combination. Results Administration of CoQ10 and DMSA resulted in protection from arsenic-induced suppression of RBCs, haematocrit and hemoglobin levels. CoQ10 and DMSA protected from arsenic-induced alteration of WBCs, basophils, neutrophils, monocytes, eosinophils and platelets. Arsenite-induced dyslipidemia was nullified by administration of CoQ10 alone or in combination with DMSA. Arsenite induced a drastic depletion of the liver and brain GSH; that was significantly blocked by CoQ10 and DMSA alone or in combination. Exposure to arsenite resulted in significant elevation of liver and kidney damage markers. The histological analysis of respective organs confirmed arsenic-induced organ damage, which was ameliorated by CoQ10 alone or when co-administered with DMSA. When administered alone, DMSA did not prevent arsenic-driven tissue damage. Conclusions Findings from this study demonstrate that CoQ10 and DMSA separately or in a combination, significantly protect against arsenic-driven toxicity in mice. It is evident that with further pre-clinical and clinical studies, an adjunct therapy that incorporates CoQ10 alongside DMSA may find applications in nullifying arsenic-driven toxicity.


2021 ◽  
Author(s):  
Jia Feng ◽  
Wenjuan Qin ◽  
Hailong Lv ◽  
Zhen Wang ◽  
Zijing Zhai ◽  
...  

Abstract Objective To observe the effects of arsenic and the protective effects of 2-aminoethoxydiphenyl borate (2-APB) and dantrolene on the trabeculae of Sprague Dawley (SD) rats. Methods Thirty-six SD rats were randomly divided into a control group and an arsenic poisoning group. After 12 weeks of arsenic exposure, six rats in the arsenic poisoning group were randomly selected for sacrifice. The remaining rats were randomly assigned to four groups (n=6 per group): natural recovery after arsenic exposure, dantrolene intervention after arsenic exposure, 2-APB intervention after arsenic exposure, and 2-APB + dantrolene intervention after arsenic exposure. After 21 days of treatment by oral gavage every other day, the bilateral femurs and tibias of the rats were scanned using micro-computed tomography (micro-CT). Bone marrow stromal cells (BMSCs) were isolated and cultured, and Ca2+ concentration and alkaline phosphatase (ALP) activity of BMSCs was assessed. Results Compared with the control group, bone mineralization density (BMD), bone volume (BV)-to-total volume (TV) ratio (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and degree of anisotropy (DA) decreased, while trabecular separation (Tb.Sp), trabecular pattern factor (TBpf), and structural model index (SMI) increased in the arsenic poisoning group (P<0.05); additionally, Ca2+ concentration increased and ALP activity decreased significantly in the arsenic poisoning group (P<0.05). Compared with the natural recovery group, after arsenic exposure, the indices of micro-CT recovered to some extent, the Ca2+ concentration of BMSCs decreased significantly, and the ALP activity of BMSCs increased significantly after intervention with 2-APB and dantrolene (P<0.05). Conclusion Arsenic can lead to significant changes in the structure of trabeculae and osteoporosis in rats, and these changes can be improved by intervention with 2-APB and dantrolene.


Author(s):  
Zhihua Ren ◽  
Huidan Deng ◽  
Qiang Wu ◽  
Guilin Jia ◽  
Niao Wen ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document