Convalescent plasma improves overall survival in patients with B-cell lymphoid malignancies and COVID-19: a longitudinal cohort and propensity score analysis

Patients with hematological malignancies and COVID-19 display a high mortality rate. In such patients, immunosuppression due to underlying disease and previous specific treatment impair humoral response, limiting viral clearance. Thus, COVID-19 convalescent plasma (CCP) therapy appears as a promising approach through the transfer of neutralizing antibodies specific to SARS-CoV-2. We report the effect of CCP in a cohort of 112 patients with hematological malignancies and COVID19 and a propensity score analysis on subgroups of patients with B-cell lymphoid disease treated (n=81) or not (n=120) with CCP between 1 May 2020 and 1 April 2021. The overall survival of the whole cohort was 65% [56-74.9] and 77.5% [68.5-87.7] for patients with B-cell neoplasm. Prior anti-CD20 monoclonal antibodies therapy was associated with better overall survival whereas age, high blood pressure, and COVID-19 severity were associated with a poor outcome. After an inverse probability of treatment weighting approach, we observed in anti-CD20 exposed patients with B-cell lymphoid disease a decreased mortality of 63% (95% CI=31%-80%) in the CCP-treated group compared to the CCP-untreated subgroup, confirmed in the other sensitivity analyses. Convalescent plasma may be beneficial in COVID-19 patients with B-cell neoplasm who are unable to mount a humoral immune response.

DELVING INTO ENGLISH AS A FOREGIN LANGUAGE STUDENTS’ PERCEPTION ON THESIS WRITING REFERENCING SYSTEM

This research aimed to investigate undergraduate EFL students’ perception towards the use of Microsoft Word Referenceson students’ thesis and factors that influence the perception. This research used a sequential mixed method. There were 25 students from 7th semester of English Language Education, Ganesha University of Education, involved in this research.The research instruments were questionnaire and interview. The results from the questionnaires were analyzed usingmean score ideal (Mi) and standard deviation ideal (SDi), and data from the interviews were analyzed using interactivemodel analysis by Miles and Huberman. From the ideal mean score analysis, the mean score of undergraduate EFLstudents’ perception towards the use of Microsoft Word References on students’ thesis was 41.84, which was categorizedas average. This means Microsoft Word References can be used in managing citation and reference in thesis writing.Moreover, the interview result shows 11 factors that influence undergraduate EFL students’ perception towards the use ofMicrosoft Word References on students’ thesis, namely attitudes, motives, interests, expectations, novelty, motion, size,background, proximity, and time. The factors build two trends, positive and negative perceptions.

Midazolam Increases The Risk of Delirium In Critically Ill Patients: A Propensity Score Analysis.

BACKGROUND: Midazolam is commonly administered in the intensive care unit (ICU) because of its limited effect on hemodynamics and stable calming and sleep-induction effects. Recent concerns about an increased risk of delirium associated with midazolam have resulted in decreased midazolam usage in the ICU. However, whether midazolam administration within 24 hours prior is related to the occurrence of delirium is still unknown.METHODS: We used real-world data from MIMIC III v1.4, MIMIC-IV v0.4 and eICU Collaborative Research to perform comparisons and assess the associated outcome effectiveness. We performed a systematic study with two cohorts to estimate the relative risks of outcomes among patients administered midazolam within 24 hours prior to delirium assessment. Propensity score matching was performed to generate a balanced 1:1 matched cohort and to identify potential prognostic factors. The outcomes included mortality, length of ICU stay, length of hospitalization, and odds of being discharged home.RESULTS: Propensity matching successfully balanced covariates for 9,348 patients (4,674 per group). There was no significant difference in hospitalization duration, (P = 0.03). However, compared to no administration of midazolam, midazolam administration was associated with a significantly higher risk for delirium (P<0.001). When compared with no midazolam administration, the use of midazolam, was associated with higher mortality and a longer ICU stay (P<0.001). Patients treated with midazolam were relatively less likely to be discharged home (P<0.001). CONCLUSIONS: Compared with no administration of midazolam, midazolam administration was associated with a difference in the incidence of delirium, mortality, ICU stay and likelihood of being discharged home but was not associated with hospitalization duration. These data suggest that midazolam may not be the preferred sedative drug for patients at risk for delirium.

Interlaboratory Comparison as a Source of Information for the Product Evaluation Process. Case Study of Ceramic Tiles Adhesives

In this study, the results obtained by 19 laboratories participating in 2 editions of the interlaboratory comparison (ILC) determining 2 properties of ceramic tiles adhesives (CTAs), i.e., initial tensile adhesion strength and tensile adhesion strength after water immersion following EN 12004, were analyzed. The results show that participating laboratories maintain a constant quality of their work. The use of z-score analysis, under ISO 13528, allows for classifying 89.5% to 100% of laboratories as satisfactory, depending on the measurement’s kind and edition. The remaining laboratories are classified as questionable. The investigation of the predominant mode of failure of the CTA’s samples tested in the two editions shows significant differences. From the perspective of laboratories, the goal of the ILC has been achieved. From the standpoint of a manufacturer who evaluates a product’s properties when placing it on the market, the results indicate the necessity of a particular treatment of the product evaluation process because the variability of the obtained results is significant. It increases the possibility of the product failing to meet the assessment criteria verified by the construction market supervision authorities. The manufacturer must consider all possible variations in the risk analysis, including the ILC results, to improve the assessment process of CTAs.

Humanitarian and Developmental Research Engagement during COVID-19

Background: Floods and storms are the most common natural hazards. Communities in remote, riparian areas are the most vulnerable in such disasters, particularly when local populations lack reliable energy and early warning systems for hazard response. Our study will investigate energy and flood resilience issues in such communities and use remote methods to enable research continuity in intra and post-pandemic contexts. Methods/Design: A two-round Delphi process will be used to interview 16 participants from Nepal and Greece to understand their priorities and preferred solutions for energy and flood resilience issues. In Round One we aim to understand the current capabilities and vulnerabilities of our focus communities in these areas. In Round Two, we seek feedback on potential options that are either market-available/evidence-informed solutions or co-developed conceptual systems. Remotely deployed semi-structured interviews are the principal method for both rounds. The Round Two structured comparative review also employs choice-based conjoint analysis and SCORE analysis. Discussion: By collecting information from both professionals and non-experts, we aim to understand what options are perceived as reliable, realistic and appropriate for flood-prone communities. The remote research design enables continuity and community access to development-focused research and its outputs, and a flexible, cost-effective approach for researchers and partner organizations.