lipid abnormalities
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2021 ◽  
Vol 15 (12) ◽  
pp. 3415-3417
Author(s):  
Zeeshan Faisal ◽  
Umber Naeem Rathore ◽  
Rabia Saeed

Objective: To evaluate the lipid abnormalities in cases with acute myocardial infarction at tertiary care hospital. Material and methods: Between May 2020 to November 2020, total 100 patients of acute myocardial infarction having age 20-40 years of both gender (male/female) were recruited from Department of Cardiology, Sheikh Zayed Medical College/Hospital, Rahim Yar Khan. Lipid abnormalities were evaluated in this study. Results: Total 100 patients with myocardial infarction were selected and lipid abnormalities were evaluated. Age range was 20-40 years with mean age 29.90 ± 6.08 years. In this study total 100 patients with acute myocardial infarction were evaluated for lipid abnormalities. Raised serum total cholesterol was noted in 38 (38%) patients followed by raised serum triglycerides in 47 (47%) patients, raised serum LDL in 26 (26%) patients and decreased serum HDL was seen in 14 (14%) patients. Conclusion: Results of this study showed that raised Triglycerides and Raised Total Cholesterol were most common lipid abnormalities in cases with acute myocardial infarction. Most of the patients were males. Obese patients were more common as compared to non-obese. Keywords: Dyslipidemia, acute myocardial infarction, Non-ST-elevation, ST elevation


2021 ◽  
Vol 2 (2) ◽  
pp. 27
Author(s):  
Catharina Natasa Bella Fortuna ◽  
Franky Chandra Satria Arisgraha, S.T., M.T. ◽  
Puspa Erawati

Based on various epidemiological studies, it is stated that blood lipids are the main risk factor for atherosclerosis that leads to coronary heart disease. In patients with blood lipid disorders, red blood cells undergo deformability so that their shape is flatter than normal red blood cells, which are round. The research entitled Application of Artificial Neural Network Method as Detection of Blood Fat Abnormalities in Image of Complete Blood Examination Results was conducted to help facilitate laboratory examinations. This research hopes that it will provide appropriate early detection to support the expert diagnosis. This research consists of two stages. The first stage is digital image processing to obtain area, perimeter, and eccentricity features. These three features will be used as input to the Backpropagation Neural Network program as the second stage. At this stage, blood lipid abnormalities are detected from features that have been obtained from image processing. The accuracy of detecting blood lipid abnormalities with ANN Backpropagation is 85%.


2021 ◽  
pp. 37-39
Author(s):  
Dipankar Kundu ◽  
Aniket Paul ◽  
Sourish Ghosh

BACKGROUND: In recent years, data suggesting that certain markers of inammation play a key role in the development and progression of atherosclerosis. hsCRP has shown promising results as a predictor of Coronary Artery Disease(CAD). OBJECTIVES: To evaluate the signicance of CRP as one of the most reliable markers in coronary artery disease and to study the role of lipid abnormalities as a risk factor in coronary artery disease. MATERIALS AND METHODS: Study was conducted at MedicalCollege, Kolkata.30 cases and 30 controls were studied. Angiographically proven cases of CAD aged between 40- 60 years of both sexes were included in the study as cases. Age and sex matched individuals without CAD weSre considered as cases. Patients with recent myocardial infarction, unstable angina (<6months).and with other inammatory conditions were excluded from the study. RESULTS: hsCRP was signicantly higher in CAD cases2.0±1.4 compared with controls0.8±0.7 and this was statistically signicant <0.001.Lipid parameters such as Total Cholesteol,Triglycerides and Low density lipoprotein were elevated in cases compared with controls and was found to be statistically signicant. Blood glucose parameters both in fasting and post-prandial conditions were found to be elevated in cases compared with controls. CONCLUSION: The study thus suggests that hsCRP level appears to be a dependable marker of CAD.Thus, hsCRP can be used as a sensitive predictor of CAD.


Endocrine ◽  
2021 ◽  
Author(s):  
M. Sampedro-Nuñez ◽  
N. Aguirre-Moreno ◽  
L. García-Fraile Fraile ◽  
S. Jiménez-Blanco ◽  
C. Knott-Torcal ◽  
...  

Abstract Introduction A small percentage of patients will develop a severe form of COVID-19 caused by SARS-CoV-2 infection. Thus, it is important to predict the potential outcomes identifying early markers of poor prognosis. In this context, we evaluated the association of SARS-CoV-2 infection with lipid abnormalities and their role in prognosis. Methods Single-center, retrospective, observational study of COVID-19 patients admitted from March to October 2020. Clinical and laboratory data, comorbidities, and treatments for COVID-19 were evaluated. Main outcomes including intensive care unit (ICU) admission and mortality were analyzed with a multivariable Cox proportional hazards regression model. Results We selected 1489 from a total of 2038 consecutive patients with confirmed COVID-19, who had a complete lipid profile before ICU admission. During the follow-up performed in 1109 patients, we observed a decrease in T-c, HDL-c, and LDL-c in 28.6%, 42.9%, and 30.4% of patients, respectively, and an increase in TG in 76.8%. The decrease of both T-c and HDL- c was correlated with a decrease in albumin levels (r = 0.39 and r = 0.37, respectively). Kaplan–Meier survival curves found an increased ICU admission in patients with lower T-c (HR 0.55, CI 0.36–0.86), HDL-c (HR 0.61, CI 0.45–0.84), and LDL-c (HR 0.85, CI 0.74–0.97). Higher values of T-c (HR 0.45, CI 0.36–0.57), HDL-c (HR 0.66, CI 0.54–0.81), and LDL-c (HR 0.86, CI 0.78–0.94) showed a protective effect on mortality. Conclusions Abnormalities in lipid profile are a frequent complication of SARS-CoV-2 infection and might be related to morbidity and mortality. Funding Proyectos de Investigación en Salud (FIS) and cofinanced by FEDER.


2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Tina Z Khan ◽  
Ulrike Schatz ◽  
Stefan R Bornstein ◽  
Mahmoud Barbir

Hypertriglyceridaemia represents one of the most prevalent lipid abnormalities, however it is often eclipsed by focus on LDL cholesterol and is frequently overlooked by clinicians, despite it being an important cardiovascular risk factor. For most patients, hypertriglyceridaemia arises from a combination of environmental factors and multiple genetic variations with small effects. Even in cases with apparent familial clustering of hypertriglyceridaemia, a monogenetic cause is rarely identified. Common secondary causes include obesity, uncontrolled diabetes, alcohol, and various commonly used drugs. Correction of these factors, along with lifestyle optimisation, should be prioritised prior to commencing medication.The goal of drug treatment is to reduce the risk of cardiovascular disease in those with moderate hypertriglyceridaemia and the risk of pancreatitis in those with severe hypertriglyceridaemia.Recent and ongoing trials demonstrate the important role of triglycerides (TG) in determining residual risk in patients with cardiovascular disease (CVD) already established on statin therapy. Novel and emerging data on omega-3 fatty acids (high-dose icosapent ethyl) and the selective PPAR modulator pemafibrate are eagerly awaited and may provide further clarity for clinicians in determining which patients will benefit from TG lowering and help inform clinical guidelines. There are numerous novel therapies on the horizon that reduce TG by decreasing the activity of proteins that inhibit lipoprotein lipase such as apolipoprotein C-III (including Volanesorsen which was recently approved in Germany) and ANGPTL 3/4 which may offer promise for the future.


2021 ◽  
Vol 5 (4) ◽  
pp. 1212-1217
Author(s):  
Jessica Herlianez Saiful ◽  
Rina Gustia

Background: Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis disease of childhood. But due to rarity of non Langerhans cell hystiosis itself, the exact prevalence of juvenile xanthogranuloma remain unknown with only a few epidemiological journal ever published. Juvenile xanthogranuloma usually wihout lipid abnormality and systemic involvement. But association between JXG and lipid abnormalities is still not well understood. We describe a patient with multiple cutaneous JXG who also developed hyperlipidemia. Case: A case of a  8 months-old baby patient with juvenile xanthogranuloma is reported.  Patient parents noticed yellowish dots on child’s face since six months ago, and it was gradually increase in size and number, and spread to trunks, upper and lower limb since 2 months ago. Patients got formula milk since 7 months ago. Patients father has uncontrolled hypercholesterolemia, and grandparents  had controlled dyslipidemia. Dermatological state showed yellowish plaque and papule on the face, trunk, lower limb, and upper limb. Dermoscopy show yellowish papule with sun setting appearance and branched and linear vessel on orange yellow background. Laboratory finding showed  elevated lipid serum. Foam cell and Touton giant  cell is found on histopathology examination. Discussion: The presented case demonstrates that skin lesions in patients with diagnosed JXG may have a variable clinical presentation, ranging from single to diffuse skin lesions, also present from the birth to childhood. The diagnosis requires histopathological confirmation to avoid misdiagnosis of malignant disease. Association between JXG and lipid abnormalities remain unknown, with most of the patient show normal  lipid serum. Majority of patients presenting lesions limited to the skin requires only a strict dermatological observation.


2021 ◽  
Vol 9 (09) ◽  
pp. 106-107
Author(s):  
Susmitha Vasanth Pentyala ◽  
Abhilash Tadiboina

Cerebrovascular accident, which has considerable mortality and morbidity,deservesattention towards its prevention. The first lines of defense in stroke prevention are detecting and adequately treating manageable risk factors, C-Reactive protein, an acute phase reactant is an indicator ofunderlying systemic inflammation and a novel marker for atherothrombotic disease. Present study is an attempt to study the levels of C-Reactive protein in acute thromboembolic stroke and to correlate between serum C Reactive protein levels and lipid profile in acute ischemic stroke.


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