A good information system must not only be neat, effective, and resilient, but also must be user friendly and up to date. In a sense, it is able to be applied to various types of electronic devices, easily accessible at any whereand time (real time), and can be modified according to user needs in a relatively easy and simple way. Information systems are now needed by various parties, especially in the field of administration and sale of medicines for Cut Nyak Dhien Hospital. During this time, recording in books has been very ineffective and caused many problems, such as difficulty in accessing old data, asa well as the information obtained was not real time. To solve it, this research raises the theme of the appropriate information system design for the hospital concerned, by utilizing CSS Bootstrap framework and research methodology for web development, namely Web Development Life Cycle. This research resulted in a responsive system by providing easy access through desktop computers, tablets, and smartphones so that it would help the hospital in the data processing process in real time.