plasma medicine
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2022 ◽  
Vol 12 (2) ◽  
pp. 644
Author(s):  
Andrei Vasile Nastuta ◽  
Torsten Gerling

Application desired functionality as well as operation expenses of cold atmospheric pressure plasma (CAP) devices scale with properties like gas selection. The present contribution provides a comparative investigation for a CAP system operated in argon or helium at different operation voltages and distance to the surface. Comparison of power dissipation, electrical field strength and optical emission spectroscopy from vacuum ultraviolet over visible up to near infrared ((V)UV-VIS-NIR) spectral range is carried out. This study is extended to safety relevant investigation of patient leakage current, induced surface temperature and species density for ozone (O3) and nitrogen oxides (NOx). It is found that in identical operation conditions (applied voltage, distance to surface and gas flow rate) the dissipated plasma power is about equal (up to 10 W), but the electrical field strength differs, having peak values of 320 kV/m for Ar and up to 300 kV/m for He. However, only for Ar CAP could we measure O3 up to 2 ppm and NOx up to 7 ppm. The surface temperature and leakage values of both systems showed different slopes, with the biggest surprise being a constant leakage current over distance for argon. These findings may open a new direction in the plasma source development for Plasma Medicine.


2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Clarissa S. Schütz ◽  
Matthias B. Stope ◽  
Sander Bekeschus

At serine139-phosphorylated gamma histone H2A.X (γH2A.X) has been established over the decades as sensitive evidence of radiation-induced DNA damage, especially DNA double-strand breaks (DSBs) in radiation biology. Therefore, γH2A.X has been considered a suitable marker for biomedical applications and a general indicator of direct DNA damage with other therapeutic agents, such as cold physical plasma. Medical plasma technology generates a partially ionized gas releasing a plethora of reactive oxygen and nitrogen species (ROS) simultaneously that have been used for therapeutic purposes such as wound healing and cancer treatment. The quantification of γH2A.X as a surrogate parameter of direct DNA damage has often been used to assess genotoxicity in plasma-treated cells, whereas no sustainable mutagenic potential of the medical plasma treatment could be identified despite H2A.X phosphorylation. However, phosphorylated H2A.X occurs during apoptosis, which is associated with exposure to cold plasma and ROS. This review summarizes the current understanding of γH2A.X induction and function in oxidative stress in general and plasma medicine in particular. Due to the progress towards understanding the mechanisms of H2A.X phosphorylation in the absence of DSB and ROS, observations of γH2A.X in medical fields should be carefully interpreted.


2021 ◽  
Vol 11 (23) ◽  
pp. 11135
Author(s):  
Jing Li ◽  
Lu-Xiang Zhao ◽  
Tao He ◽  
Wei-Wu Dong ◽  
Yue Yuan ◽  
...  

Cold atmospheric plasmas (CAPs) used in plasma medicine have shown great potential in various aspects including wound healing, dermatology, cancer therapy, etc. It is one of the important issues to determine the plasma dosage in plasma medicine because it dominates the specific plasma treatment results. However, the multi-process interactions between CAPs and biological materials make it rather challenging to give an accurate and versatile definition for plasma dosage. In this study, the ratio of the discharge energy to the number of the treated in vitro kidney cells (mJ/cell) was employed as the unit of the plasma dosage. Additionally, inspired by basic knowledge of pharmacy, the median lethal dose (LD50) was employed to help estimate the plasma dosage. The experimental results show that the value of LD50 using the newly designed CAP Bio-Med Platform for the kidney cells is 34.67 mJ/cell. This biology-based method has the advantages of easy operation, independence of specific CAP sources, and also independence of complex interactions between CAPs and the treated biological targets, and consequently, may provide a new direction to quantitatively define the plasma dosage in various plasma medical applications.


2021 ◽  
Vol MA2021-02 (16) ◽  
pp. 684-684
Author(s):  
Xinpei Lu

2021 ◽  
pp. 2100112
Author(s):  
Li Lin ◽  
Dayun Yan ◽  
Taeyoung Lee ◽  
Michael Keidar

2021 ◽  
Author(s):  
Li Lin ◽  
Dayun Yan ◽  
Luis Martinez ◽  
Yi Liu ◽  
Michael Keidar

2021 ◽  
Vol 11 (10) ◽  
pp. 4584
Author(s):  
Nagendra Kumar Kaushik ◽  
Sander Bekeschus ◽  
Hiromasa Tanaka ◽  
Abraham Lin ◽  
Eun Ha Choi

This Special Issue, entitled “Plasma Medicine Technologies”, covers the latest remarkable developments in the field of plasma bioscience and medicine. Plasma medicine is an interdisciplinary field that combines the principles of plasma physics, material science, bioscience, and medicine, towards the development of therapeutic strategies. A study on plasma medicine has yielded the development of new treatment opportunities in medical and dental sciences. An important aspect of this issue is the presentation of research underlying new therapeutic methods that are useful in medicine, dentistry, sterilization, and, in the current scenario, that challenge perspectives in biomedical sciences. This issue is focused on basic research on the characterization of the bioplasma sources applicable to living cells, especially to the human body, and fundamental research on the mutual interactions between bioplasma and organic–inorganic liquids, and bio or nanomaterials.


2021 ◽  
Vol 30 (1) ◽  
pp. 015002
Author(s):  
Augusto Stancampiano ◽  
Pablo Escot Bocanegra ◽  
Sébastien Dozias ◽  
Jean-Michel Pouvesle ◽  
Eric Robert
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