The Effects of Tobacco Coverage in the Public Communication Environment on Young People’s Decisions to Smoke Combustible Cigarettes

In today’s complex media environment, does media coverage influence youth and young adults’ (YYA) tobacco use and intentions? We conceptualize the “public communication environment” and effect mediators, then ask whether over time variation in exogenously measured tobacco media coverage from mass and social media sources predicts daily YYA cigarette smoking intentions measured in a rolling nationally representative phone survey (N = 11,847 on 1,147 days between May 2014 and June 2017). Past week anti-tobacco and pro-tobacco content from Twitter, newspapers, broadcast news, Associated Press, and web blogs made coherent scales (thetas = 0.77 and 0.79). Opportunities for exposure to anti-tobacco content in the past week predicted lower intentions to smoke (Odds ratio [OR] = 0.95, p < .05, 95% confidence interval [CI] = 0.91–1.00). The effect was stronger among current smokers than among nonsmokers (interaction OR = 0.88, p < .05, 95% CI = 0.77–1.00). These findings support specific effects of anti-tobacco media coverage and illustrate a productive general approach to conceptualizing and assessing effects in the complex media environment.

Direct expansion of Fourier extrapolator for one-way wave equation using Chebyshev polynomials of the second kind

The Fourier method for one-way wave propagation is efficient, but potentially inaccurate in complex media. The implicit finite-difference method can handle arbitrarily complex media, but can be inefficient in 3D and has limited dip bandwidth. We proposed a new Fourier method based on Chebyshev expansion of the second kind. Both theoretical analyses and numerical experiments show that the proposed method is comprehensively superior to a similar method based on Chebyshev expansion of the first kind in terms of balanced amplitude and error tolerance. Within the dip bandwidth from 0 to 65°, the fourth-order form of our method has an error tolerance of 2%, which is about one-third that of Chebyshev expansion of the first kind. Our method is also superior to the implicit finite-difference method in several important aspects: effective bandwidth, computational efficiency, numerical dispersion and two-way splitting error. It can be easily extended from 2D to 3D compared with the finite-difference method and from low orders to high orders compared with the optimized Chebyshev-Fourier method. The proposed method shows better imaging results of the SEG/EAGE model by providing a well-focused salt dome, flank and bottom as well as the detailed structures beneath the salt body, compared with the implicit finite-difference method and Chebyshev expansion of the first kind; meanwhile, our method has less imaging artifacts since it can better position the reflectors.

Thermal Analysis of Protein Stability and Ligand Binding in Complex Media

ABSTRACTScreening of ligands that can bind to biologic products of in vitro expression systems typically requires some purification of the expressed biologic target. Such purification is often laborious and time consuming and a limiting challenge. What is required, that could represent an enormous advantage, is the ability to screen expressed proteins in the crude lysate stage without purification. For that purpose, we explore here the utility of differential scanning calorimetry (DSC) measurements for detecting the presence of specific proteins and their interactions with ligands in the complex media where they were prepared, i.e. crude lysates. Model systems were designed to mimic analogous conditions comparable to those that might be encountered in actual in vitro expression systems. Results are reported for several examples where DSC measurements distinctly showed differences in the thermal denaturation behaviors of the crude lysate alone, proteins and proteins plus binding ligands added to the crude lysate. Results were obtained for Streptavidin/Biotin binding in E. coli lysate, and binding of Angiotensin Converting Enzyme 2 (ACE2) by captopril or lisinopril in the lysate supernatant derived from cultured Human Kidney cells (HEK293). ACE2 binding by the reactive binding domain (RBC) of SARS-CoV-2 was also examined. Binding of ACE2 by RBC and lisinopril were similar and consistent with the reported ACE2 inhibitory activity of lisinopril.

Animal Oppression and Solidarity: Examining Representations of Animals and Their Allies in Twenty-First Century Media

Popular media, both literature and film, provide a location in which animal suffering, resistance and solidarity are finally visible. An examination of Bong Joon-ho’s award-winning film Okja (2017) and Karen Joy Fowler’s New York Timesbest-selling novel We Are All Completely Beside Ourselves (2013) reveals complex media representations of animals that highlight the significance of twenty-first century media in depicting the animal in the human world.

An optimised one-way wave migration method for complex media with arbitrarily varying velocity based on eigen-decomposition

The classical one-way generalised screen propagator (GSP) and Fourier finite-difference (FFD) schemes have limitations in imaging large angles in complex media with substantial lateral variations in wave velocity. Some improvements to the classical one-way wave scheme have been proposed with optimised methods. However, the performance of these methods in imaging complex media remains unsatisfying. To overcome this issue, a new strategy for wavefield extrapolation based on the eigenvalue and eigenvector decomposition of the Helmholtz operator is presented herein. In this method, the square root operator is calculated after the decomposition of the Helmholtz operator at the product of the eigenvalues and eigenvectors. Then, Euler transformation is applied using the best polynomial approximation of the trigonometric function based on the infinite norm, and the propagator for one-way wave migration is calculated. According to this scheme, a one-way operator can be computed more accurately with a lower-order expansion. The imaging performance of this scheme was compared with that of the classical GSP, FFD and the recently developed full-wave-equation depth migration (FWDM) schemes. The impulse responses in media with arbitrary velocity inhomogeneity demonstrate that the proposed migration scheme performs better at large angles than the classical GSP scheme. The wavefronts calculated in the dipping and salt dome models illustrate that this scheme can provide a precise wavefield calculation. The applications of the Marmousi model further demonstrate that the proposed approach can achieve better-migrated results in imaging small-scale and complex structures, especially in media with steep-dipping faults.